Heterogeneity and Inaccuracy in Protein Structures Solved by X-Ray Crystallography

Proteins are dynamic molecules, exhibiting structural heterogeneity in the form of anisotropic motion and discrete conformational substates, often of functional importance. In protein structure determination by X-ray crystallography, the observed diffraction pattern results from the scattering of X-...

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Veröffentlicht in:	Structure (London) 2004-05, Vol.12 (5), p.831-838
Hauptverfasser:	DePristo, Mark A, de Bakker, Paul I.W, Blundell, Tom L
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray HIV - chemistry HIV - enzymology HIV Protease - chemistry Models, Molecular Protein Structure, Tertiary
Online-Zugang:	Volltext
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