Autoregulation of NFATc1/A Expression Facilitates Effector T Cells to Escape from Rapid Apoptosis

Threshold levels of individual NFAT factors appear to be critical for apoptosis induction in effector T cells. In these cells, the short isoform A of NFATc1 is induced to high levels due to the autoregulation of the NFATc1 promoter P1 by NFATs. P1 is located within a CpG island in front of exon 1, r...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2002-06, Vol.16 (6), p.881-895
Hauptverfasser:	Chuvpilo, Sergei, Jankevics, Eriks, Tyrsin, Dimitri, Akimzhanov, Askar, Moroz, Denis, Jha, Mithilesh Kumar, Schulze-Luehrmann, Jan, Santner-Nanan, Brigitte, Feoktistova, Elizaveta, König, Thomas, Avots, Andris, Schmitt, Edgar, Berberich-Siebelt, Friederike, Schimpl, Anneliese, Serfling, Edgar
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Apoptosis Base Sequence Defects Deoxyribonuclease I - metabolism Deoxyribonucleic acid DNA DNA Methylation DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Electrophoresis, Polyacrylamide Gel Homeostasis Humans Jurkat Cells Ligands Lymphocytes Mice Mice, Inbred BALB C Molecular Sequence Data NFATC Transcription Factors Nuclear Proteins Poly A - metabolism Promoter Regions, Genetic Proteins Rodents Studies T-Lymphocytes, Regulatory - physiology Transcription Factors - biosynthesis Transcription Factors - genetics Transcription, Genetic
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