Major Hepatic Resection for Hilar Cholangiocarcinoma: Analysis of 46 Patients
HYPOTHESIS Major hepatectomy, bile duct resection, and regional lymphadenectomy for hilar cholangiocarcinoma are associated with actual long-term (>5 years) survival. DESIGN Retrospective outcome study. SETTING Single tertiary referral institution. PATIENTS Between 1979 and 1997, 46 consecutive p...
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| Veröffentlicht in: | Archives of surgery (Chicago. 1960) 2004-05, Vol.139 (5), p.514-525 |
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| container_title | Archives of surgery (Chicago. 1960) |
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| creator | Rea, David J Munoz-Juarez, Manuel Farnell, Michael B Donohue, John H Que, Florencia G Crownhart, Brian Larson, Dirk Nagorney, David M |
| description | HYPOTHESIS Major hepatectomy, bile duct resection, and regional lymphadenectomy for hilar cholangiocarcinoma are associated with actual long-term (>5 years) survival. DESIGN Retrospective outcome study. SETTING Single tertiary referral institution. PATIENTS Between 1979 and 1997, 46 consecutive patients had resection of hilar cholangiocarcinoma by major hepatectomy, bile duct resection, and regional lymphadenectomy. MAIN OUTCOME MEASURES Overall survival and tumor recurrence were correlated to clinicopathological factors, operative morbidity, and mortality. RESULTS Twenty-five patients underwent left hepatectomy, 17 underwent right hepatectomy, and 4 had extended right hepatectomy. Eighteen patients underwent resection of segment 1. Negative (R0) resection margins were achieved in 37 patients (80%). The operative mortality rate was 9%, and the surgical morbidity rate was 52%. Actual 1-year, 3-year, and 5-year survival rates were 80%, 39%, and 26%, respectively. Factors adversely associated with patient survival rates included: male sex, lymph node metastases, tumor grade 3 or 4, elevated direct serum bilirubin level at diagnosis, elevated preoperative activated partial thromboplastin time, and more than 4 U of red blood cells transfused perioperatively. Tumor size and R0 resection approached significance for survival. Factors associated with tumor recurrence included: male sex, tumor grade 3 or 4, a low hemoglobin level both at diagnosis and preoperatively, and a low preoperative prothrombin time and low alkaline phosphatase level at diagnosis and preoperatively. Median time to recurrence was 3.6 years. Tumor recurrence was predominantly local and regional. CONCLUSIONS The actual 5-year survival rate of 26% justifies major partial hepatectomy, bile duct resection, and regional lymphadenectomy for hilar cholangiocarcinoma. The high frequency of local and regional recurrence warrants investigation of adjuvant therapy.Arch Surg. 2004;139:514-525--> |
| doi_str_mv | 10.1001/archsurg.139.5.514 |
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DESIGN Retrospective outcome study. SETTING Single tertiary referral institution. PATIENTS Between 1979 and 1997, 46 consecutive patients had resection of hilar cholangiocarcinoma by major hepatectomy, bile duct resection, and regional lymphadenectomy. MAIN OUTCOME MEASURES Overall survival and tumor recurrence were correlated to clinicopathological factors, operative morbidity, and mortality. RESULTS Twenty-five patients underwent left hepatectomy, 17 underwent right hepatectomy, and 4 had extended right hepatectomy. Eighteen patients underwent resection of segment 1. Negative (R0) resection margins were achieved in 37 patients (80%). The operative mortality rate was 9%, and the surgical morbidity rate was 52%. Actual 1-year, 3-year, and 5-year survival rates were 80%, 39%, and 26%, respectively. Factors adversely associated with patient survival rates included: male sex, lymph node metastases, tumor grade 3 or 4, elevated direct serum bilirubin level at diagnosis, elevated preoperative activated partial thromboplastin time, and more than 4 U of red blood cells transfused perioperatively. Tumor size and R0 resection approached significance for survival. Factors associated with tumor recurrence included: male sex, tumor grade 3 or 4, a low hemoglobin level both at diagnosis and preoperatively, and a low preoperative prothrombin time and low alkaline phosphatase level at diagnosis and preoperatively. Median time to recurrence was 3.6 years. Tumor recurrence was predominantly local and regional. CONCLUSIONS The actual 5-year survival rate of 26% justifies major partial hepatectomy, bile duct resection, and regional lymphadenectomy for hilar cholangiocarcinoma. The high frequency of local and regional recurrence warrants investigation of adjuvant therapy.Arch Surg. 2004;139:514-525--></description><identifier>ISSN: 0004-0010</identifier><identifier>ISSN: 2168-6254</identifier><identifier>EISSN: 1538-3644</identifier><identifier>EISSN: 2168-6262</identifier><identifier>DOI: 10.1001/archsurg.139.5.514</identifier><identifier>PMID: 15136352</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Aged ; Bile Duct Neoplasms - mortality ; Bile Duct Neoplasms - pathology ; Bile Duct Neoplasms - surgery ; Bile Ducts, Intrahepatic - surgery ; Cholangiocarcinoma - mortality ; Cholangiocarcinoma - pathology ; Cholangiocarcinoma - surgery ; Female ; Hepatectomy ; Humans ; Lymph Node Excision ; Male ; Middle Aged ; Neoplasm Invasiveness ; Proportional Hazards Models ; Retrospective Studies ; Survival Analysis</subject><ispartof>Archives of surgery (Chicago. 1960), 2004-05, Vol.139 (5), p.514-525</ispartof><rights>Copyright American Medical Association May 2004</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamasurgery/articlepdf/10.1001/archsurg.139.5.514$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/archsurg.139.5.514$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,315,781,785,3341,27926,27927,76491,76494</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15136352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rea, David J</creatorcontrib><creatorcontrib>Munoz-Juarez, Manuel</creatorcontrib><creatorcontrib>Farnell, Michael B</creatorcontrib><creatorcontrib>Donohue, John H</creatorcontrib><creatorcontrib>Que, Florencia G</creatorcontrib><creatorcontrib>Crownhart, Brian</creatorcontrib><creatorcontrib>Larson, Dirk</creatorcontrib><creatorcontrib>Nagorney, David M</creatorcontrib><title>Major Hepatic Resection for Hilar Cholangiocarcinoma: Analysis of 46 Patients</title><title>Archives of surgery (Chicago. 1960)</title><addtitle>Arch Surg</addtitle><description>HYPOTHESIS Major hepatectomy, bile duct resection, and regional lymphadenectomy for hilar cholangiocarcinoma are associated with actual long-term (>5 years) survival. DESIGN Retrospective outcome study. SETTING Single tertiary referral institution. PATIENTS Between 1979 and 1997, 46 consecutive patients had resection of hilar cholangiocarcinoma by major hepatectomy, bile duct resection, and regional lymphadenectomy. MAIN OUTCOME MEASURES Overall survival and tumor recurrence were correlated to clinicopathological factors, operative morbidity, and mortality. RESULTS Twenty-five patients underwent left hepatectomy, 17 underwent right hepatectomy, and 4 had extended right hepatectomy. Eighteen patients underwent resection of segment 1. Negative (R0) resection margins were achieved in 37 patients (80%). The operative mortality rate was 9%, and the surgical morbidity rate was 52%. Actual 1-year, 3-year, and 5-year survival rates were 80%, 39%, and 26%, respectively. Factors adversely associated with patient survival rates included: male sex, lymph node metastases, tumor grade 3 or 4, elevated direct serum bilirubin level at diagnosis, elevated preoperative activated partial thromboplastin time, and more than 4 U of red blood cells transfused perioperatively. Tumor size and R0 resection approached significance for survival. Factors associated with tumor recurrence included: male sex, tumor grade 3 or 4, a low hemoglobin level both at diagnosis and preoperatively, and a low preoperative prothrombin time and low alkaline phosphatase level at diagnosis and preoperatively. Median time to recurrence was 3.6 years. Tumor recurrence was predominantly local and regional. CONCLUSIONS The actual 5-year survival rate of 26% justifies major partial hepatectomy, bile duct resection, and regional lymphadenectomy for hilar cholangiocarcinoma. The high frequency of local and regional recurrence warrants investigation of adjuvant therapy.Arch Surg. 2004;139:514-525--></description><subject>Aged</subject><subject>Bile Duct Neoplasms - mortality</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Bile Ducts, Intrahepatic - surgery</subject><subject>Cholangiocarcinoma - mortality</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Cholangiocarcinoma - surgery</subject><subject>Female</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><issn>0004-0010</issn><issn>2168-6254</issn><issn>1538-3644</issn><issn>2168-6262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1PxCAURYnR6PjxA3RhGhfuWoEHlLqbTPxKZqIxuiaU0plO2jJCu_Dfi5lRE1cQOPe-l4PQBcEZwZjcaG9WYfTLjECR8YwTtocmhINMQTC2jyYYY5ZGEh-h4xDW8UZlQQ_REeEEBHA6QYuFXjufPNqNHhqTvNpgzdC4Pqm_X5tW-2S2cq3ul40zcWDTu07fJtNet5-hCYmrEyaSlxi2_RBO0UGt22DPducJer-_e5s9pvPnh6fZdJ5qWvAhrSRQzIoqrxnBHFfMlqImBTFVBbgUtpZMG8kMWEFNCUZKrfPciFKyqgYm4QRdb3s33n2MNgyqa4KxbdzTujGoPJYRCTiCV__AtRt9XD4oCpSzAghEiG4h410I3tZq45tO-09FsPo2rX5Mq2hacRVNx9DlrnksO1v9RXZqI3C-BXSnf3-hELmQ8AUaAYMW</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Rea, David J</creator><creator>Munoz-Juarez, Manuel</creator><creator>Farnell, Michael B</creator><creator>Donohue, John H</creator><creator>Que, Florencia G</creator><creator>Crownhart, Brian</creator><creator>Larson, Dirk</creator><creator>Nagorney, David M</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Major Hepatic Resection for Hilar Cholangiocarcinoma: Analysis of 46 Patients</title><author>Rea, David J ; Munoz-Juarez, Manuel ; Farnell, Michael B ; Donohue, John H ; Que, Florencia G ; Crownhart, Brian ; Larson, Dirk ; Nagorney, David M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a295t-d832049d7f41050d4eb6f191cdd30b6ef84ac84c3e62cb3c88aa77c6b84df3483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Bile Duct Neoplasms - mortality</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Duct Neoplasms - surgery</topic><topic>Bile Ducts, Intrahepatic - surgery</topic><topic>Cholangiocarcinoma - mortality</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Cholangiocarcinoma - surgery</topic><topic>Female</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Rea, David J</creatorcontrib><creatorcontrib>Munoz-Juarez, Manuel</creatorcontrib><creatorcontrib>Farnell, Michael B</creatorcontrib><creatorcontrib>Donohue, John H</creatorcontrib><creatorcontrib>Que, Florencia G</creatorcontrib><creatorcontrib>Crownhart, Brian</creatorcontrib><creatorcontrib>Larson, Dirk</creatorcontrib><creatorcontrib>Nagorney, David M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of surgery (Chicago. 1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rea, David J</au><au>Munoz-Juarez, Manuel</au><au>Farnell, Michael B</au><au>Donohue, John H</au><au>Que, Florencia G</au><au>Crownhart, Brian</au><au>Larson, Dirk</au><au>Nagorney, David M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Major Hepatic Resection for Hilar Cholangiocarcinoma: Analysis of 46 Patients</atitle><jtitle>Archives of surgery (Chicago. 1960)</jtitle><addtitle>Arch Surg</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>139</volume><issue>5</issue><spage>514</spage><epage>525</epage><pages>514-525</pages><issn>0004-0010</issn><issn>2168-6254</issn><eissn>1538-3644</eissn><eissn>2168-6262</eissn><abstract>HYPOTHESIS Major hepatectomy, bile duct resection, and regional lymphadenectomy for hilar cholangiocarcinoma are associated with actual long-term (>5 years) survival. DESIGN Retrospective outcome study. SETTING Single tertiary referral institution. PATIENTS Between 1979 and 1997, 46 consecutive patients had resection of hilar cholangiocarcinoma by major hepatectomy, bile duct resection, and regional lymphadenectomy. MAIN OUTCOME MEASURES Overall survival and tumor recurrence were correlated to clinicopathological factors, operative morbidity, and mortality. RESULTS Twenty-five patients underwent left hepatectomy, 17 underwent right hepatectomy, and 4 had extended right hepatectomy. Eighteen patients underwent resection of segment 1. Negative (R0) resection margins were achieved in 37 patients (80%). The operative mortality rate was 9%, and the surgical morbidity rate was 52%. Actual 1-year, 3-year, and 5-year survival rates were 80%, 39%, and 26%, respectively. Factors adversely associated with patient survival rates included: male sex, lymph node metastases, tumor grade 3 or 4, elevated direct serum bilirubin level at diagnosis, elevated preoperative activated partial thromboplastin time, and more than 4 U of red blood cells transfused perioperatively. Tumor size and R0 resection approached significance for survival. Factors associated with tumor recurrence included: male sex, tumor grade 3 or 4, a low hemoglobin level both at diagnosis and preoperatively, and a low preoperative prothrombin time and low alkaline phosphatase level at diagnosis and preoperatively. Median time to recurrence was 3.6 years. Tumor recurrence was predominantly local and regional. CONCLUSIONS The actual 5-year survival rate of 26% justifies major partial hepatectomy, bile duct resection, and regional lymphadenectomy for hilar cholangiocarcinoma. The high frequency of local and regional recurrence warrants investigation of adjuvant therapy.Arch Surg. 2004;139:514-525--></abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>15136352</pmid><doi>10.1001/archsurg.139.5.514</doi><tpages>12</tpages></addata></record> |
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| subjects | Aged Bile Duct Neoplasms - mortality Bile Duct Neoplasms - pathology Bile Duct Neoplasms - surgery Bile Ducts, Intrahepatic - surgery Cholangiocarcinoma - mortality Cholangiocarcinoma - pathology Cholangiocarcinoma - surgery Female Hepatectomy Humans Lymph Node Excision Male Middle Aged Neoplasm Invasiveness Proportional Hazards Models Retrospective Studies Survival Analysis |
| title | Major Hepatic Resection for Hilar Cholangiocarcinoma: Analysis of 46 Patients |
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