Th1 Cells Regulate Hematopoietic Progenitor Cell Homeostasis by Production of Oncostatin M

Regulation of hematopoietic progenitor cell homeostasis is crucial for maintenance of innate immunity and the ability of the body to respond to injury and infection. In this report, we demonstrate that progenitor cell numbers and cycling status in vivo are dramatically increased in mice deficient in...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2002-06, Vol.16 (6), p.815-825
Hauptverfasser:	Broxmeyer, Hal E, Bruns, Heather A, Zhang, Shangming, Cooper, Scott, Hangoc, Giao, McKenzie, Andrew N.J, Dent, Alexander L, Schindler, Ulrike, Naeger, Lisa K, Hoey, Timothy, Kaplan, Mark H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Bone marrow CD4-Positive T-Lymphocytes - physiology Colonies & territories DNA-Binding Proteins - physiology Flow cytometry Gene expression Hematopoietic Stem Cells - physiology Homeostasis Humans Immune system Lymphocytes Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Oncostatin M Peptides - metabolism Recruitment Rodents Spleen STAT4 Transcription Factor STAT6 Transcription Factor Th1 Cells - physiology Trans-Activators - physiology Transgenic animals
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