Vertebral forward slippage in immature lumbar spine occurs following epiphyseal separation and its occurrence is unrelated to disc degeneration: Is the pediatric spondylolisthesis a physis stress fracture of vertebral body?
Radiographic and histologic evaluation of a rat model of lumbar spine slippage. To clarify the pathomechanism of slippage in the immature spine. There are controversial hypotheses regarding the pathogenesis of slippage of the pediatric spine with pars defects. Some studies supported that disc degene...
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| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 2004-03, Vol.29 (5), p.524-527 |
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| creator | KOICHI SAIRYO SHINSUKE KATOH SAKAMAKI, Tadanori MEGUMI INOUE KOMATSUBARA, Shinji OGAWA, Takayuki SANO, Toshiaki GOEL, Vijay K YASUI, Natsuo |
| description | Radiographic and histologic evaluation of a rat model of lumbar spine slippage.
To clarify the pathomechanism of slippage in the immature spine.
There are controversial hypotheses regarding the pathogenesis of slippage of the pediatric spine with pars defects. Some studies supported that disc degeneration was its cause, while others indicated the growth plate injury was the cause.
An immature lumbar spine slippage model in 4-week-old rats was used. Following posterior destabilizing surgery, the lumbar spine was radiographically and histologically examined at 1, 3, 5, and 7 days after surgery.
Radiographically, slippage occurred about 7% in the % slip on day 7, and no slippage was observed before day 5. Histologically, epiphyseal separation also appeared on day 7; before day 5, the growth plate showed no abnormalities. Within 7 days after the operation, the anulus fibrosus did not show any sign indicating degeneration. The nucleus pulposus was also normal up to day 7.
The findings of this study support the hypothesis that vertebral forward slippage of the immature spine occurs following epiphyseal separation and its occurrence is unrelated to disc degeneration. |
| doi_str_mv | 10.1097/01.BRS.0000106492.51581.9B |
| format | Article |
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To clarify the pathomechanism of slippage in the immature spine.
There are controversial hypotheses regarding the pathogenesis of slippage of the pediatric spine with pars defects. Some studies supported that disc degeneration was its cause, while others indicated the growth plate injury was the cause.
An immature lumbar spine slippage model in 4-week-old rats was used. Following posterior destabilizing surgery, the lumbar spine was radiographically and histologically examined at 1, 3, 5, and 7 days after surgery.
Radiographically, slippage occurred about 7% in the % slip on day 7, and no slippage was observed before day 5. Histologically, epiphyseal separation also appeared on day 7; before day 5, the growth plate showed no abnormalities. Within 7 days after the operation, the anulus fibrosus did not show any sign indicating degeneration. The nucleus pulposus was also normal up to day 7.
The findings of this study support the hypothesis that vertebral forward slippage of the immature spine occurs following epiphyseal separation and its occurrence is unrelated to disc degeneration.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/01.BRS.0000106492.51581.9B</identifier><identifier>PMID: 15129065</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Animals ; Biological and medical sciences ; Biomechanical Phenomena ; Cerebrospinal fluid. Meninges. Spinal cord ; Child ; Disease Models, Animal ; Epiphyses - diagnostic imaging ; Epiphyses - injuries ; Epiphyses - pathology ; Female ; Fractures, Stress - complications ; Fractures, Stress - diagnostic imaging ; Fractures, Stress - pathology ; Growth Plate - diagnostic imaging ; Growth Plate - pathology ; Humans ; Intervertebral Disc - diagnostic imaging ; Intervertebral Disc - pathology ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - growth & development ; Lumbar Vertebrae - injuries ; Lumbar Vertebrae - pathology ; Magnetic Resonance Imaging ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Radiography ; Rats ; Rats, Wistar ; Salter-Harris Fractures ; Spinal Diseases - diagnostic imaging ; Spinal Diseases - etiology ; Spinal Diseases - pathology ; Spinal Fractures - complications ; Spinal Fractures - diagnostic imaging ; Spinal Fractures - pathology ; Spondylolisthesis - diagnostic imaging ; Spondylolisthesis - etiology ; Spondylolisthesis - pathology</subject><ispartof>Spine (Philadelphia, Pa. 1976), 2004-03, Vol.29 (5), p.524-527</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c317t-9b3e0474c095bfe899f82c1f4e6727612caab31767072c52060d240668a4a3ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15560562$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15129065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOICHI SAIRYO</creatorcontrib><creatorcontrib>SHINSUKE KATOH</creatorcontrib><creatorcontrib>SAKAMAKI, Tadanori</creatorcontrib><creatorcontrib>MEGUMI INOUE</creatorcontrib><creatorcontrib>KOMATSUBARA, Shinji</creatorcontrib><creatorcontrib>OGAWA, Takayuki</creatorcontrib><creatorcontrib>SANO, Toshiaki</creatorcontrib><creatorcontrib>GOEL, Vijay K</creatorcontrib><creatorcontrib>YASUI, Natsuo</creatorcontrib><title>Vertebral forward slippage in immature lumbar spine occurs following epiphyseal separation and its occurrence is unrelated to disc degeneration: Is the pediatric spondylolisthesis a physis stress fracture of vertebral body?</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>Radiographic and histologic evaluation of a rat model of lumbar spine slippage.
To clarify the pathomechanism of slippage in the immature spine.
There are controversial hypotheses regarding the pathogenesis of slippage of the pediatric spine with pars defects. Some studies supported that disc degeneration was its cause, while others indicated the growth plate injury was the cause.
An immature lumbar spine slippage model in 4-week-old rats was used. Following posterior destabilizing surgery, the lumbar spine was radiographically and histologically examined at 1, 3, 5, and 7 days after surgery.
Radiographically, slippage occurred about 7% in the % slip on day 7, and no slippage was observed before day 5. Histologically, epiphyseal separation also appeared on day 7; before day 5, the growth plate showed no abnormalities. Within 7 days after the operation, the anulus fibrosus did not show any sign indicating degeneration. The nucleus pulposus was also normal up to day 7.
The findings of this study support the hypothesis that vertebral forward slippage of the immature spine occurs following epiphyseal separation and its occurrence is unrelated to disc degeneration.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Child</subject><subject>Disease Models, Animal</subject><subject>Epiphyses - diagnostic imaging</subject><subject>Epiphyses - injuries</subject><subject>Epiphyses - pathology</subject><subject>Female</subject><subject>Fractures, Stress - complications</subject><subject>Fractures, Stress - diagnostic imaging</subject><subject>Fractures, Stress - pathology</subject><subject>Growth Plate - diagnostic imaging</subject><subject>Growth Plate - pathology</subject><subject>Humans</subject><subject>Intervertebral Disc - diagnostic imaging</subject><subject>Intervertebral Disc - pathology</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - growth & development</subject><subject>Lumbar Vertebrae - injuries</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Radiography</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Salter-Harris Fractures</subject><subject>Spinal Diseases - diagnostic imaging</subject><subject>Spinal Diseases - etiology</subject><subject>Spinal Diseases - pathology</subject><subject>Spinal Fractures - complications</subject><subject>Spinal Fractures - diagnostic imaging</subject><subject>Spinal Fractures - pathology</subject><subject>Spondylolisthesis - diagnostic imaging</subject><subject>Spondylolisthesis - etiology</subject><subject>Spondylolisthesis - pathology</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkd1u1DAQhSMEoqXwCshCgrtdPE7irHuDuhU_lSoh8XcbTZzJ1sixgyeh2qflVXC7K4pvbGm-c2bGpyhegVyDNM1bCevtl69rmQ9IXRm1rqHewNpsHxWnUKvNCqA2j4tTWWq1UlWpT4pnzD8zr0swT4sTqEEZqevT4s8PSjN1Cb0YYrrF1Av2bppwR8IF4cYR5yWR8MvYYRI8uUAiWrskzgLv460LO0GTm272TNmFacKEs4tBYOiFm_mAJwo2W7JYQiKPM_VijqJ3bEVPOwp0EJ2LKxbzDYmJeodzcjb3jKHf--gd5wJnCxR33fKD50ScB0lo76eMg_j9b58u9vt3z4snA3qmF8f7rPj-4f23y0-r688fry4vrle2hGZema4kWTWVlabuBtoYM2yUhaEi3ahGg7KIXSZ1IxtlayW17FUltd5ghaXF8qx4c_CdUvy1EM_tmFcj7zFQXLhtwABIgAyeH0CbInOioZ2SGzHtW5DtXbythDbH2z7E297H25ptFr88dlm6kfoH6THPDLw-AsgWff6YYB3_x9Va1lqVfwFY97UD</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>KOICHI SAIRYO</creator><creator>SHINSUKE KATOH</creator><creator>SAKAMAKI, Tadanori</creator><creator>MEGUMI INOUE</creator><creator>KOMATSUBARA, Shinji</creator><creator>OGAWA, Takayuki</creator><creator>SANO, Toshiaki</creator><creator>GOEL, Vijay K</creator><creator>YASUI, Natsuo</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Vertebral forward slippage in immature lumbar spine occurs following epiphyseal separation and its occurrence is unrelated to disc degeneration: Is the pediatric spondylolisthesis a physis stress fracture of vertebral body?</title><author>KOICHI SAIRYO ; SHINSUKE KATOH ; SAKAMAKI, Tadanori ; MEGUMI INOUE ; KOMATSUBARA, Shinji ; OGAWA, Takayuki ; SANO, Toshiaki ; GOEL, Vijay K ; YASUI, Natsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-9b3e0474c095bfe899f82c1f4e6727612caab31767072c52060d240668a4a3ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Cerebrospinal fluid. Meninges. Spinal cord</topic><topic>Child</topic><topic>Disease Models, Animal</topic><topic>Epiphyses - diagnostic imaging</topic><topic>Epiphyses - injuries</topic><topic>Epiphyses - pathology</topic><topic>Female</topic><topic>Fractures, Stress - complications</topic><topic>Fractures, Stress - diagnostic imaging</topic><topic>Fractures, Stress - pathology</topic><topic>Growth Plate - diagnostic imaging</topic><topic>Growth Plate - pathology</topic><topic>Humans</topic><topic>Intervertebral Disc - diagnostic imaging</topic><topic>Intervertebral Disc - pathology</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - growth & development</topic><topic>Lumbar Vertebrae - injuries</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Radiography</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Salter-Harris Fractures</topic><topic>Spinal Diseases - diagnostic imaging</topic><topic>Spinal Diseases - etiology</topic><topic>Spinal Diseases - pathology</topic><topic>Spinal Fractures - complications</topic><topic>Spinal Fractures - diagnostic imaging</topic><topic>Spinal Fractures - pathology</topic><topic>Spondylolisthesis - diagnostic imaging</topic><topic>Spondylolisthesis - etiology</topic><topic>Spondylolisthesis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOICHI SAIRYO</creatorcontrib><creatorcontrib>SHINSUKE KATOH</creatorcontrib><creatorcontrib>SAKAMAKI, Tadanori</creatorcontrib><creatorcontrib>MEGUMI INOUE</creatorcontrib><creatorcontrib>KOMATSUBARA, Shinji</creatorcontrib><creatorcontrib>OGAWA, Takayuki</creatorcontrib><creatorcontrib>SANO, Toshiaki</creatorcontrib><creatorcontrib>GOEL, Vijay K</creatorcontrib><creatorcontrib>YASUI, Natsuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOICHI SAIRYO</au><au>SHINSUKE KATOH</au><au>SAKAMAKI, Tadanori</au><au>MEGUMI INOUE</au><au>KOMATSUBARA, Shinji</au><au>OGAWA, Takayuki</au><au>SANO, Toshiaki</au><au>GOEL, Vijay K</au><au>YASUI, Natsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vertebral forward slippage in immature lumbar spine occurs following epiphyseal separation and its occurrence is unrelated to disc degeneration: Is the pediatric spondylolisthesis a physis stress fracture of vertebral body?</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>29</volume><issue>5</issue><spage>524</spage><epage>527</epage><pages>524-527</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>Radiographic and histologic evaluation of a rat model of lumbar spine slippage.
To clarify the pathomechanism of slippage in the immature spine.
There are controversial hypotheses regarding the pathogenesis of slippage of the pediatric spine with pars defects. Some studies supported that disc degeneration was its cause, while others indicated the growth plate injury was the cause.
An immature lumbar spine slippage model in 4-week-old rats was used. Following posterior destabilizing surgery, the lumbar spine was radiographically and histologically examined at 1, 3, 5, and 7 days after surgery.
Radiographically, slippage occurred about 7% in the % slip on day 7, and no slippage was observed before day 5. Histologically, epiphyseal separation also appeared on day 7; before day 5, the growth plate showed no abnormalities. Within 7 days after the operation, the anulus fibrosus did not show any sign indicating degeneration. The nucleus pulposus was also normal up to day 7.
The findings of this study support the hypothesis that vertebral forward slippage of the immature spine occurs following epiphyseal separation and its occurrence is unrelated to disc degeneration.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>15129065</pmid><doi>10.1097/01.BRS.0000106492.51581.9B</doi><tpages>4</tpages></addata></record> |
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| ispartof | Spine (Philadelphia, Pa. 1976), 2004-03, Vol.29 (5), p.524-527 |
| issn | 0362-2436 1528-1159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71911011 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Biomechanical Phenomena Cerebrospinal fluid. Meninges. Spinal cord Child Disease Models, Animal Epiphyses - diagnostic imaging Epiphyses - injuries Epiphyses - pathology Female Fractures, Stress - complications Fractures, Stress - diagnostic imaging Fractures, Stress - pathology Growth Plate - diagnostic imaging Growth Plate - pathology Humans Intervertebral Disc - diagnostic imaging Intervertebral Disc - pathology Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - growth & development Lumbar Vertebrae - injuries Lumbar Vertebrae - pathology Magnetic Resonance Imaging Medical sciences Nervous system (semeiology, syndromes) Neurology Radiography Rats Rats, Wistar Salter-Harris Fractures Spinal Diseases - diagnostic imaging Spinal Diseases - etiology Spinal Diseases - pathology Spinal Fractures - complications Spinal Fractures - diagnostic imaging Spinal Fractures - pathology Spondylolisthesis - diagnostic imaging Spondylolisthesis - etiology Spondylolisthesis - pathology |
| title | Vertebral forward slippage in immature lumbar spine occurs following epiphyseal separation and its occurrence is unrelated to disc degeneration: Is the pediatric spondylolisthesis a physis stress fracture of vertebral body? |
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