Role of Ca2+ in induction of neurotransmitter-related gene expression by butyrate

We examined the effect of butyrate on neurotransmitter-related gene expression and calcium homeostasis in PC12 cells. Pretreatment with Ca chelators (EGTA or BAPTA-AM) attenuated the butyrate-triggered accumulation of TH and ppEnk mRNA indicating that Ca plays a role in butyrate-induced regulation o...

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Veröffentlicht in:	Neuroreport 2004-05, Vol.15 (7), p.1177-1181
Hauptverfasser:	Zia, Muhammad T, Nankova, Bistra B, Krishnan, Kavitha, Gueorguiev, Volodia D, Frenz, Christopher M, Sabban, Esther L, La Gamma, Edmund F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Butyrates - pharmacology Calcium - physiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Intracellular Fluid - drug effects Intracellular Fluid - metabolism Intracellular Fluid - physiology Neurotransmitter Agents - biosynthesis Neurotransmitter Agents - metabolism PC12 Cells Rats Vertebrates: nervous system and sense organs
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