Early onset of chondroitin sulfate and osteopontin expression in angiotensin ii-dependent left ventricular hypertrophy

Chondroitin sulfate proteoglycan (CSPG) is expressed during embryonic heart development and osteopontin (OPN) is an important mediator of the profibrotic effects of angiotensin II (Ang II). The objective of this study was to analyze extracellular matrix protein (ECMP) expression in Ang II-dependent...

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Veröffentlicht in:	American journal of hypertension 2002-07, Vol.15 (7), p.644-652
Hauptverfasser:	Rothermund, Lars, Kreutz, Reinhold, Kossmehl, Peter, Fredersdorf, Sabine, Shakibaei, Mehdi, Schulze-Tanzil, Gundula, Paul, Martin, Grimm, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin Angiotensin II - physiology Animals Animals, Genetically Modified Atrial Natriuretic Factor - genetics Biological and medical sciences Blood Pressure Blotting, Western Cardiology. Vascular system chondroitin sulfate Chondroitin Sulfate Proteoglycans - analysis Chondroitin Sulfate Proteoglycans - genetics Collagen Type I - analysis Collagen Type I - genetics Extracellular matrix Extracellular Matrix - chemistry Gene Expression - physiology Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Ventricles - chemistry hypertrophy Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - pathology Male Medical sciences Myocardium - chemistry Myocardium - pathology Myocytes, Cardiac - chemistry Myocytes, Cardiac - pathology Organ Size Osteopontin Rats Rats, Sprague-Dawley RNA, Messenger - analysis Sialoglycoproteins - analysis Sialoglycoproteins - genetics Ventricular Function, Left
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