Silvestrol and Episilvestrol, Potential Anticancer Rocaglate Derivatives from Aglaia silvestris

Two cytotoxic rocaglate derivatives possessing an unusual dioxanyloxy unit, silvestrol (1) and episilvestrol (2), were isolated from the fruits and twigs of Aglaia silvestris by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma (KB) cell line. Additionally, two new bacch...

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Veröffentlicht in:	Journal of organic chemistry 2004-05, Vol.69 (10), p.3350-3358
Hauptverfasser:	Hwang, Bang Yeon, Su, Bao-Ning, Chai, Heebyung, Mi, Qiuwen, Kardono, Leonardus B. S, Afriastini, Johar J, Riswan, Soedarsono, Santarsiero, Bernard D, Mesecar, Andrew D, Wild, Robert, Fairchild, Craig R, Vite, Gregory D, Rose, William C, Farnsworth, Norman R, Cordell, Geoffrey A, Pezzuto, John M, Swanson, Steven M, Kinghorn, A. Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aglaia - chemistry Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Cell Line, Tumor Drug Screening Assays, Antitumor Endothelium, Vascular - drug effects General pharmacology Humans KB Cells Leukemia P388 Medical sciences Mice Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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