Evaluation of Homology Modeling of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Main Protease for Structure Based Drug Design

To accelerate the development of drugs against severe acute respiratory syndrome (SARS), we constructed a homology model of the SARS coronavirus main protease using our modeling software, FAMS Ligand&Complex, and released it before the X-ray structure was solved. The X-ray structure showed our m...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2004, Vol.52(5), pp.643-645
Hauptverfasser:	Takeda-Shitaka, Mayuko, Nojima, Hiroyuki, Takaya, Daisuke, Kanou, Kazuhiko, Iwadate, Mitsuo, Umeyama, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemical synthesis Cysteine Endopeptidases Drug Design Drug Evaluation, Preclinical - methods Endopeptidases - chemistry homology modeling Models, Molecular normal mode analysis SARS coronavirus SARS Virus - enzymology severe acute respiratory syndrome (SARS) Structural Homology, Protein structure based drug design Structure-Activity Relationship Viral Proteins - chemistry
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