Evaluation of Homology Modeling of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Main Protease for Structure Based Drug Design
To accelerate the development of drugs against severe acute respiratory syndrome (SARS), we constructed a homology model of the SARS coronavirus main protease using our modeling software, FAMS Ligand&Complex, and released it before the X-ray structure was solved. The X-ray structure showed our m...
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| Veröffentlicht in: | Chemical & Pharmaceutical Bulletin 2004, Vol.52(5), pp.643-645 |
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| container_end_page | 645 |
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| container_issue | 5 |
| container_start_page | 643 |
| container_title | Chemical & Pharmaceutical Bulletin |
| container_volume | 52 |
| creator | Takeda-Shitaka, Mayuko Nojima, Hiroyuki Takaya, Daisuke Kanou, Kazuhiko Iwadate, Mitsuo Umeyama, Hideaki |
| description | To accelerate the development of drugs against severe acute respiratory syndrome (SARS), we constructed a homology model of the SARS coronavirus main protease using our modeling software, FAMS Ligand&Complex, and released it before the X-ray structure was solved. The X-ray structure showed our model as accurately predicted and useful for structure based drug design. |
| doi_str_mv | 10.1248/cpb.52.643 |
| format | Article |
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Pharm. Bull.</addtitle><description>To accelerate the development of drugs against severe acute respiratory syndrome (SARS), we constructed a homology model of the SARS coronavirus main protease using our modeling software, FAMS Ligand&Complex, and released it before the X-ray structure was solved. 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| fulltext | fulltext |
| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 2004, Vol.52(5), pp.643-645 |
| issn | 0009-2363 1347-5223 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Antiviral Agents - chemical synthesis Cysteine Endopeptidases Drug Design Drug Evaluation, Preclinical - methods Endopeptidases - chemistry homology modeling Models, Molecular normal mode analysis SARS coronavirus SARS Virus - enzymology severe acute respiratory syndrome (SARS) Structural Homology, Protein structure based drug design Structure-Activity Relationship Viral Proteins - chemistry |
| title | Evaluation of Homology Modeling of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Main Protease for Structure Based Drug Design |
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