Cerebral blood flow velocity changes to visual stimuli in patients with multiple sclerosis
We assessed the blood flow velocity (BFv) changes to visual stimuli using transcranial Doppler (TCD) in patients with multiple sclerosis (MS) during an exacerbation period by means of vasoneuronal coupling. Eighty-four patients (19 men, 75 women) and 45 healthy subjects (14 men, 31 women) were studi...
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| Veröffentlicht in: | Multiple sclerosis 2002-05, Vol.8 (3), p.217-221 |
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| creator | Uzuner, N Özkan, S Gücüyener, D Özdemir, G |
| description | We assessed the blood flow velocity (BFv) changes to visual stimuli using transcranial Doppler (TCD) in patients with multiple sclerosis (MS) during an exacerbation period by means of vasoneuronal coupling. Eighty-four patients (19 men, 75 women) and 45 healthy subjects (14 men, 31 women) were studied. Both posterior cerebral arteries (PCAs) were simultaneously monitored by TCD sonography during 10 cycles of 20 s eyes open observing complex moving visual images, and 20 s eyes closed at the end of every cycle. TCD sonography was performed at least at the first 2 days of exacerbation. Mean cerebral BFv throughout the procedure (p =0.003, p =0.001; right and left sides, respectively), velocity at rest (p =0.001, p |
| doi_str_mv | 10.1191/1352458502ms798oa |
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Eighty-four patients (19 men, 75 women) and 45 healthy subjects (14 men, 31 women) were studied. Both posterior cerebral arteries (PCAs) were simultaneously monitored by TCD sonography during 10 cycles of 20 s eyes open observing complex moving visual images, and 20 s eyes closed at the end of every cycle. TCD sonography was performed at least at the first 2 days of exacerbation. Mean cerebral BFv throughout the procedure (p =0.003, p =0.001; right and left sides, respectively), velocity at rest (p =0.001, p <0.001), and velocity at stimulation (p =0.021, p =0.01) on both PCAs were significantly lower in patients than controls. However, BFv changes to visual stimulation on both sides were significantly higher in patients (p =0.01, p =0.031) compared to controls. There were negative correlations between P100 latencies and relative blood flow changes on both sides, but it was not significant on the left side. These results may suggest that patients with MS during exacerbation have more reactive vessels in the posterior circulation and/or more reactive neurons in the occipital cortex.</description><identifier>ISSN: 1352-4585</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1191/1352458502ms798oa</identifier><identifier>PMID: 12120693</identifier><identifier>CODEN: MUSCFZ</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adult ; Biological and medical sciences ; Cerebrovascular Circulation ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Multiple Sclerosis - diagnostic imaging ; Multiple Sclerosis - physiopathology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. 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Eighty-four patients (19 men, 75 women) and 45 healthy subjects (14 men, 31 women) were studied. Both posterior cerebral arteries (PCAs) were simultaneously monitored by TCD sonography during 10 cycles of 20 s eyes open observing complex moving visual images, and 20 s eyes closed at the end of every cycle. TCD sonography was performed at least at the first 2 days of exacerbation. Mean cerebral BFv throughout the procedure (p =0.003, p =0.001; right and left sides, respectively), velocity at rest (p =0.001, p <0.001), and velocity at stimulation (p =0.021, p =0.01) on both PCAs were significantly lower in patients than controls. However, BFv changes to visual stimulation on both sides were significantly higher in patients (p =0.01, p =0.031) compared to controls. There were negative correlations between P100 latencies and relative blood flow changes on both sides, but it was not significant on the left side. These results may suggest that patients with MS during exacerbation have more reactive vessels in the posterior circulation and/or more reactive neurons in the occipital cortex.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cerebrovascular Circulation</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - diagnostic imaging</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Photic Stimulation</subject><subject>Reaction Time</subject><subject>Tropical medicine</subject><subject>Ultrasonography, Doppler, Transcranial</subject><issn>1352-4585</issn><issn>1477-0970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp10E1rHSEUBmApKU2a9gdkEySQ7ibxYxydZbmkHxDopt1kM6hzJjE4463HSci_r-FeuNDSlaLPOb4eQs44u-K859dcKtEqo5iYUfcm2TfkhLdaN6zX7Kju633zCo7Je8RHxpjWUr0jx1xwwbpenpC7DWRw2UbqYkojnWJ6pk8Qkw_lhfoHu9wD0pLoU8C1KixhXmOgYaFbWwIsBelzKA-0npawjUDRR8gJA34gbycbET7u11Py68vNz8235vbH1--bz7eNl70sjdCcgwc2CStdC5r3o3NSgQDtxlaDbLUXojNqdNZapXoOxnqwggmtR-PkKfm067vN6fcKWIY5oIcY7QJpxaF2ZJ1hpsKLv-BjWvNSsw2CG6NU13UV8R3y9ROYYRq2Ocw2vwycDa9TH_6Zeq053zde3QzjoWI_5gou98Cit3HKdvEBD052fVtDVne1c2jv4ZDu_y__ActOmkI</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Uzuner, N</creator><creator>Özkan, S</creator><creator>Gücüyener, D</creator><creator>Özdemir, G</creator><general>SAGE Publications</general><general>Arnold</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Cerebral blood flow velocity changes to visual stimuli in patients with multiple sclerosis</title><author>Uzuner, N ; Özkan, S ; Gücüyener, D ; Özdemir, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-2711ece0f2a3b4e719dbb35e2e7bd47e347c22685dbaaa5591e8acea20277d8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cerebrovascular Circulation</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - diagnostic imaging</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Photic Stimulation</topic><topic>Reaction Time</topic><topic>Tropical medicine</topic><topic>Ultrasonography, Doppler, Transcranial</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uzuner, N</creatorcontrib><creatorcontrib>Özkan, S</creatorcontrib><creatorcontrib>Gücüyener, D</creatorcontrib><creatorcontrib>Özdemir, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Multiple sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uzuner, N</au><au>Özkan, S</au><au>Gücüyener, D</au><au>Özdemir, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral blood flow velocity changes to visual stimuli in patients with multiple sclerosis</atitle><jtitle>Multiple sclerosis</jtitle><addtitle>Mult Scler</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>8</volume><issue>3</issue><spage>217</spage><epage>221</epage><pages>217-221</pages><issn>1352-4585</issn><eissn>1477-0970</eissn><coden>MUSCFZ</coden><abstract>We assessed the blood flow velocity (BFv) changes to visual stimuli using transcranial Doppler (TCD) in patients with multiple sclerosis (MS) during an exacerbation period by means of vasoneuronal coupling. Eighty-four patients (19 men, 75 women) and 45 healthy subjects (14 men, 31 women) were studied. Both posterior cerebral arteries (PCAs) were simultaneously monitored by TCD sonography during 10 cycles of 20 s eyes open observing complex moving visual images, and 20 s eyes closed at the end of every cycle. TCD sonography was performed at least at the first 2 days of exacerbation. Mean cerebral BFv throughout the procedure (p =0.003, p =0.001; right and left sides, respectively), velocity at rest (p =0.001, p <0.001), and velocity at stimulation (p =0.021, p =0.01) on both PCAs were significantly lower in patients than controls. However, BFv changes to visual stimulation on both sides were significantly higher in patients (p =0.01, p =0.031) compared to controls. There were negative correlations between P100 latencies and relative blood flow changes on both sides, but it was not significant on the left side. These results may suggest that patients with MS during exacerbation have more reactive vessels in the posterior circulation and/or more reactive neurons in the occipital cortex.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>12120693</pmid><doi>10.1191/1352458502ms798oa</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Cerebrovascular Circulation Female Humans Male Medical sciences Middle Aged Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Photic Stimulation Reaction Time Tropical medicine Ultrasonography, Doppler, Transcranial |
| title | Cerebral blood flow velocity changes to visual stimuli in patients with multiple sclerosis |
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