Preclinical evaluation of a class of infectivity-enhanced adenoviral vectors in ovarian cancer gene therapy

Ovarian carcinoma cells are often infected inefficiently by adenoviruses (Ad) due to low expression of coxsackie–adenovirus receptors (CAR), hindering the application of adenovirus-mediated gene therapy in ovarian cancer. In this study, we explored a class of infectivity-enhanced Ad vectors, which c...

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Veröffentlicht in:	Gene therapy 2004-05, Vol.11 (10), p.874-878
Hauptverfasser:	Wu, H, Han, T, Lam, J T, Leath, C A, Dmitriev, I, Kashentseva, E, Barnes, M N, Alvarez, R D, Curiel, D T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - pathogenicity Adenovirus Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animal models Animals Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology brief-communication Cell Biology Coxsackievirus Disease Models, Animal Expression vectors Female Female genital diseases Fundamental and applied biological sciences. Psychology Gene Expression Gene Targeting Gene Therapy Gene transfer Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors Gynecology. Andrology. Obstetrics Health. Pharmaceutical industry Human Genetics Humans Industrial applications and implications. Economical aspects Infectivity Medical sciences Mice Mice, SCID Nanotechnology Neoplasm Transplantation Oligopeptides - genetics Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - therapy Polylysine Polylysine - genetics Statistical analysis Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumor cell lines Tumor Cells, Cultured Tumors Vectors (Biology) Xenografts
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