Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents
The synthesis, antiviral, antifungal and anticancer activities of 4– 10 is described. The synthesis and evaluation of some 2-substituted-1,4-naphthoquinones 2, S-(1,4-naphthoquinon-2-yl)-mercaptoalkanoic acid amides 4, related benzoquinone and naphthoquinone derivatives 6– 9 and 2,3-disubstituted 1,...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2004-06, Vol.14 (11), p.2901-2904 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Tandon, Vishnu K. Singh, Ravindra V. Yadav, Dharmendra B. |
| description | The synthesis, antiviral, antifungal and anticancer activities of
4–
10 is described.
The synthesis and evaluation of some 2-substituted-1,4-naphthoquinones
2,
S-(1,4-naphthoquinon-2-yl)-mercaptoalkanoic acid amides
4, related benzoquinone and naphthoquinone derivatives
6–
9 and 2,3-disubstituted 1,4-naphthoquinones
10–
11 were carried out. The antifungal, antibacterial, antiviral and anticancer activities were determined by using the standard assay. The results show that compounds
2b and
10a showed in vitro antiviral activity against
Inflenza-A Virus and
Herpes Simplex Virus and possess pronounced antifungal profile whereas
4a showed anticancer activites against
Lymphoid Leukaemia P 388. |
| doi_str_mv | 10.1016/j.bmcl.2004.03.047 |
| format | Article |
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4–
10 is described.
The synthesis and evaluation of some 2-substituted-1,4-naphthoquinones
2,
S-(1,4-naphthoquinon-2-yl)-mercaptoalkanoic acid amides
4, related benzoquinone and naphthoquinone derivatives
6–
9 and 2,3-disubstituted 1,4-naphthoquinones
10–
11 were carried out. The antifungal, antibacterial, antiviral and anticancer activities were determined by using the standard assay. The results show that compounds
2b and
10a showed in vitro antiviral activity against
Inflenza-A Virus and
Herpes Simplex Virus and possess pronounced antifungal profile whereas
4a showed anticancer activites against
Lymphoid Leukaemia P 388.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2004.03.047</identifier><identifier>PMID: 15125956</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Anti-Infective Agents - chemical synthesis ; Anti-Infective Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antineoplastic agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacology ; Antiviral agents ; Biological and medical sciences ; Cell Line, Tumor ; Cell Survival - drug effects ; General aspects ; Influenza A virus - drug effects ; Leukemia, Lymphoid - pathology ; Medical sciences ; Mice ; Microbial Sensitivity Tests ; Naphthoquinones - chemical synthesis ; Naphthoquinones - pharmacology ; Pharmacology. Drug treatments ; Simplexvirus - drug effects ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (11), p.2901-2904</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-2b4e7105b9b5db692f979a75b3f70ae8fcccafcb52f3506d4c0b3000a5d210aa3</citedby><cites>FETCH-LOGICAL-c382t-2b4e7105b9b5db692f979a75b3f70ae8fcccafcb52f3506d4c0b3000a5d210aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2004.03.047$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15753088$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15125956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tandon, Vishnu K.</creatorcontrib><creatorcontrib>Singh, Ravindra V.</creatorcontrib><creatorcontrib>Yadav, Dharmendra B.</creatorcontrib><title>Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>The synthesis, antiviral, antifungal and anticancer activities of
4–
10 is described.
The synthesis and evaluation of some 2-substituted-1,4-naphthoquinones
2,
S-(1,4-naphthoquinon-2-yl)-mercaptoalkanoic acid amides
4, related benzoquinone and naphthoquinone derivatives
6–
9 and 2,3-disubstituted 1,4-naphthoquinones
10–
11 were carried out. The antifungal, antibacterial, antiviral and anticancer activities were determined by using the standard assay. The results show that compounds
2b and
10a showed in vitro antiviral activity against
Inflenza-A Virus and
Herpes Simplex Virus and possess pronounced antifungal profile whereas
4a showed anticancer activites against
Lymphoid Leukaemia P 388.</description><subject>Animals</subject><subject>Anti-Infective Agents - chemical synthesis</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>General aspects</subject><subject>Influenza A virus - drug effects</subject><subject>Leukemia, Lymphoid - pathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Naphthoquinones - chemical synthesis</subject><subject>Naphthoquinones - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Simplexvirus - drug effects</subject><subject>Structure-Activity Relationship</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpabZJ_0APxZf2FDsjW_IH9BJCmxYCPaSF3MRIHmW1eOWtZBvy7ytnF5pTTzMDz_syPIx94FBw4PXVrtB7MxQlgCigKkA0r9iGi1rklQD5mm2gqyFvO_Fwxt7FuAPgAoR4y8645KXsZL1h4_2Tn7YUXczQ9xktOMw4udFno838uNCQ8UuRezxsp-34Z3Z-9JT1FNySsIVSbE2m1QUcLp9XO_tHHJ771tOgNxQyfCQ_xQv2xuIQ6f1pnrPf377-uvme3_28_XFzfZebqi2nvNSCGg5Sd1r2uu5K2zUdNlJXtgGk1hpj0BotS1tJqHthQFcAgLIvOSBW5-zzsfcQ0tcUJ7V30dAwoKdxjqrhHci64Qksj6AJY4yBrDoEt8fwpDioVbPaqVWzWjUrqFTSnEIfT-2z3lP_L3LymoBPJwCjwcGG5MDFF1wjK2jbxH05cpRcLI6CisZR8tW7QGZS_ej-98dfwdediA</recordid><startdate>20040607</startdate><enddate>20040607</enddate><creator>Tandon, Vishnu K.</creator><creator>Singh, Ravindra V.</creator><creator>Yadav, Dharmendra B.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040607</creationdate><title>Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents</title><author>Tandon, Vishnu K. ; Singh, Ravindra V. ; Yadav, Dharmendra B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-2b4e7105b9b5db692f979a75b3f70ae8fcccafcb52f3506d4c0b3000a5d210aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Anti-Infective Agents - chemical synthesis</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>General aspects</topic><topic>Influenza A virus - drug effects</topic><topic>Leukemia, Lymphoid - pathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Naphthoquinones - chemical synthesis</topic><topic>Naphthoquinones - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Simplexvirus - drug effects</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tandon, Vishnu K.</creatorcontrib><creatorcontrib>Singh, Ravindra V.</creatorcontrib><creatorcontrib>Yadav, Dharmendra B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tandon, Vishnu K.</au><au>Singh, Ravindra V.</au><au>Yadav, Dharmendra B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2004-06-07</date><risdate>2004</risdate><volume>14</volume><issue>11</issue><spage>2901</spage><epage>2904</epage><pages>2901-2904</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>The synthesis, antiviral, antifungal and anticancer activities of
4–
10 is described.
The synthesis and evaluation of some 2-substituted-1,4-naphthoquinones
2,
S-(1,4-naphthoquinon-2-yl)-mercaptoalkanoic acid amides
4, related benzoquinone and naphthoquinone derivatives
6–
9 and 2,3-disubstituted 1,4-naphthoquinones
10–
11 were carried out. The antifungal, antibacterial, antiviral and anticancer activities were determined by using the standard assay. The results show that compounds
2b and
10a showed in vitro antiviral activity against
Inflenza-A Virus and
Herpes Simplex Virus and possess pronounced antifungal profile whereas
4a showed anticancer activites against
Lymphoid Leukaemia P 388.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15125956</pmid><doi>10.1016/j.bmcl.2004.03.047</doi><tpages>4</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (11), p.2901-2904 |
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| language | eng |
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| subjects | Animals Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antiviral agents Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects General aspects Influenza A virus - drug effects Leukemia, Lymphoid - pathology Medical sciences Mice Microbial Sensitivity Tests Naphthoquinones - chemical synthesis Naphthoquinones - pharmacology Pharmacology. Drug treatments Simplexvirus - drug effects Structure-Activity Relationship |
| title | Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents |
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