Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions

Radiotherapy represents a major treatment option for patients with pancreatic cancer, but recent evidence suggests that radiation can promote invasion and metastasis of cancer cells. Interactions between cancer cells and surrounding stromal cells may play an important role in aggressive tumor progre...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-05, Vol.64 (9), p.3215-3222
Hauptverfasser:	OHUCHIDA, Kenoki, MIZUMOTO, Kazuhiro, MURAKAMI, Mitsuhiko, QIAN, Li-Wu, SATO, Norihiro, NAGAI, Eishi, MATSUMOTO, Kunio, NAKAMURA, Toshikazu, TANAKA, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cell Communication - physiology Cell Communication - radiation effects Cell Line, Tumor Coculture Techniques Fibroblasts - metabolism Fibroblasts - radiation effects Growth Substances - metabolism Hepatocyte Growth Factor - biosynthesis Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - pharmacology Humans Medical sciences Mitogen-Activated Protein Kinases - metabolism Mitogens Neoplasm Invasiveness Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pharmacology. Drug treatments Phosphorylation Proto-Oncogene Proteins c-met - biosynthesis Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics Stromal Cells - metabolism Stromal Cells - radiation effects Tumors
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