Plasma precursors of brain catecholaminergic and serotonergic neurotransmitters in rehabilitation patients with ischemic stroke
Aquilani R, Verri M, Iadarola P, Arcidiaco P, Boschi F, Dossena M, Sessarego P, Scocchi M, Arrigoni N, Pastoris O. Plasma precursors of brain catecholaminergic and serotonergic neurotransmitters in rehabilitation patients with ischemic stroke. Arch Phys Med Rehabil 2004;85:779–84. To determine level...
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| creator | Aquilani, Roberto Verri, Manuela Iadarola, Paolo Arcidiaco, Patrizia Boschi, Federica Dossena, Maurizia Sessarego, Paolo Scocchi, Marco Arrigoni, Nadia Pastoris, Ornella |
| description | Aquilani R, Verri M, Iadarola P, Arcidiaco P, Boschi F, Dossena M, Sessarego P, Scocchi M, Arrigoni N, Pastoris O. Plasma precursors of brain catecholaminergic and serotonergic neurotransmitters in rehabilitation patients with ischemic stroke. Arch Phys Med Rehabil 2004;85:779–84.
To determine levels of plasma amino acid tyrosine and tryptophan, precursors of brain catecholamine and serotonin neurotransmitters, respectively, in rehabilitative patients with ischemic stroke.
Controlled, pre-post analysis, consecutive sample.
Rehabilitation center.
Twenty men with ischemic stroke (age, 68±11.3y) consecutively admitted into rehabilitation 15±10 days (range, 7–28d) after an acute cerebrovascular insult; 15 healthy sedentary subjects (controls 1); and 13 healthy hypoactive individuals who had recently had knee arthroplasty (controls 2). Both control groups were matched to stroke subjects for age, gender, and body weight.
At 8:00
am, after overnight fasting, venous blood samples were drawn from patients to determine plasma tyrosine and tryptophan levels. A nutritional evaluation, including nitrogen balance, was made. The same procedures were repeated after 45 days of rehabilitation. Amino acid data were compared with those obtained from the controls.
Plasma concentrations of amino acids.
Patients with ischemic stroke, on admission, had lower plasma tyrosine concentration than did both controls 1 (
P |
| doi_str_mv | 10.1016/j.apmr.2003.06.030 |
| format | Article |
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To determine levels of plasma amino acid tyrosine and tryptophan, precursors of brain catecholamine and serotonin neurotransmitters, respectively, in rehabilitative patients with ischemic stroke.
Controlled, pre-post analysis, consecutive sample.
Rehabilitation center.
Twenty men with ischemic stroke (age, 68±11.3y) consecutively admitted into rehabilitation 15±10 days (range, 7–28d) after an acute cerebrovascular insult; 15 healthy sedentary subjects (controls 1); and 13 healthy hypoactive individuals who had recently had knee arthroplasty (controls 2). Both control groups were matched to stroke subjects for age, gender, and body weight.
At 8:00
am, after overnight fasting, venous blood samples were drawn from patients to determine plasma tyrosine and tryptophan levels. A nutritional evaluation, including nitrogen balance, was made. The same procedures were repeated after 45 days of rehabilitation. Amino acid data were compared with those obtained from the controls.
Plasma concentrations of amino acids.
Patients with ischemic stroke, on admission, had lower plasma tyrosine concentration than did both controls 1 (
P<.0005) and controls 2 (
P<.001), but a similar tryptophan level. The plasma content of tyrosine was similar between the 2 control groups. After 45 days of rehabilitation, the stroke patients’ tyrosine and tryptophan levels remained virtually unchanged, as did nutritional parameters. Nutritional intakes were adequate to meet body needs but insufficient to correct plasma tyrosine.
Patients experiencing a recent stroke may have low plasma tyrosine levels and, therefore, reduced brain catecholamine formation. It is possible that an imbalance of brain neurotransmitters may occur.</description><identifier>ISSN: 0003-9993</identifier><identifier>EISSN: 1532-821X</identifier><identifier>DOI: 10.1016/j.apmr.2003.06.030</identifier><identifier>PMID: 15129403</identifier><identifier>CODEN: APMHAI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Amino acids ; Biological and medical sciences ; Brain Ischemia - blood ; Brain Ischemia - rehabilitation ; Case-Control Studies ; Diseases of the osteoarticular system ; Humans ; Male ; Medical sciences ; Neurology ; Nutritional Status ; Plasma ; Rehabilitation ; Stroke ; Stroke - blood ; Stroke Rehabilitation ; Traumas. Diseases due to physical agents ; Tryptophan - blood ; Tyrosine - blood ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Archives of physical medicine and rehabilitation, 2004-05, Vol.85 (5), p.779-784</ispartof><rights>2004 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003999303009912$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15718904$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15129403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aquilani, Roberto</creatorcontrib><creatorcontrib>Verri, Manuela</creatorcontrib><creatorcontrib>Iadarola, Paolo</creatorcontrib><creatorcontrib>Arcidiaco, Patrizia</creatorcontrib><creatorcontrib>Boschi, Federica</creatorcontrib><creatorcontrib>Dossena, Maurizia</creatorcontrib><creatorcontrib>Sessarego, Paolo</creatorcontrib><creatorcontrib>Scocchi, Marco</creatorcontrib><creatorcontrib>Arrigoni, Nadia</creatorcontrib><creatorcontrib>Pastoris, Ornella</creatorcontrib><title>Plasma precursors of brain catecholaminergic and serotonergic neurotransmitters in rehabilitation patients with ischemic stroke</title><title>Archives of physical medicine and rehabilitation</title><addtitle>Arch Phys Med Rehabil</addtitle><description>Aquilani R, Verri M, Iadarola P, Arcidiaco P, Boschi F, Dossena M, Sessarego P, Scocchi M, Arrigoni N, Pastoris O. Plasma precursors of brain catecholaminergic and serotonergic neurotransmitters in rehabilitation patients with ischemic stroke. Arch Phys Med Rehabil 2004;85:779–84.
To determine levels of plasma amino acid tyrosine and tryptophan, precursors of brain catecholamine and serotonin neurotransmitters, respectively, in rehabilitative patients with ischemic stroke.
Controlled, pre-post analysis, consecutive sample.
Rehabilitation center.
Twenty men with ischemic stroke (age, 68±11.3y) consecutively admitted into rehabilitation 15±10 days (range, 7–28d) after an acute cerebrovascular insult; 15 healthy sedentary subjects (controls 1); and 13 healthy hypoactive individuals who had recently had knee arthroplasty (controls 2). Both control groups were matched to stroke subjects for age, gender, and body weight.
At 8:00
am, after overnight fasting, venous blood samples were drawn from patients to determine plasma tyrosine and tryptophan levels. A nutritional evaluation, including nitrogen balance, was made. The same procedures were repeated after 45 days of rehabilitation. Amino acid data were compared with those obtained from the controls.
Plasma concentrations of amino acids.
Patients with ischemic stroke, on admission, had lower plasma tyrosine concentration than did both controls 1 (
P<.0005) and controls 2 (
P<.001), but a similar tryptophan level. The plasma content of tyrosine was similar between the 2 control groups. After 45 days of rehabilitation, the stroke patients’ tyrosine and tryptophan levels remained virtually unchanged, as did nutritional parameters. Nutritional intakes were adequate to meet body needs but insufficient to correct plasma tyrosine.
Patients experiencing a recent stroke may have low plasma tyrosine levels and, therefore, reduced brain catecholamine formation. It is possible that an imbalance of brain neurotransmitters may occur.</description><subject>Aged</subject><subject>Amino acids</subject><subject>Biological and medical sciences</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - rehabilitation</subject><subject>Case-Control Studies</subject><subject>Diseases of the osteoarticular system</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Nutritional Status</subject><subject>Plasma</subject><subject>Rehabilitation</subject><subject>Stroke</subject><subject>Stroke - blood</subject><subject>Stroke Rehabilitation</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Tryptophan - blood</subject><subject>Tyrosine - blood</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0003-9993</issn><issn>1532-821X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU2LFDEQhoMo7rj6BzxIX_TWvfnoZBLwIotfsLAeVvAWqpNqJ2N3p03Syp7862bYETwVlTxvUfW-hLxktGOUqatjB-ucOk6p6KjqqKCPyI5JwVvN2bfHZEfrT2uMERfkWc7H2iop2FNywSTjpqdiR_58mSDP0KwJ3ZZyTLmJYzMkCEvjoKA7xAnmsGD6HlwDi28yplji-WHBrXYJljyHUrCqqy7hAYYwhQIlxKVZa8Gl5OZ3KIcmZHfAuUpzSfEHPidPRpgyvjjXS_L1w_u760_tze3Hz9fvblrkhpeWaeakAC1HMUotucDe9OgV1z0oMKMcmB_8fpDSG6mZ507pPXoKqtccPYpL8uZh7prizw1zsXPdBKcJFoxbtntmaK-oruCrM7gNM3q7pjBDurf_LKvA6zMA2cE01uNdyP9xe6brrMq9feCwnvUrYLLZVR8c-lC9LtbHYBm1pyTt0Z6StKckLVW2Jin-AhTZlF4</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Aquilani, Roberto</creator><creator>Verri, Manuela</creator><creator>Iadarola, Paolo</creator><creator>Arcidiaco, Patrizia</creator><creator>Boschi, Federica</creator><creator>Dossena, Maurizia</creator><creator>Sessarego, Paolo</creator><creator>Scocchi, Marco</creator><creator>Arrigoni, Nadia</creator><creator>Pastoris, Ornella</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Plasma precursors of brain catecholaminergic and serotonergic neurotransmitters in rehabilitation patients with ischemic stroke</title><author>Aquilani, Roberto ; Verri, Manuela ; Iadarola, Paolo ; Arcidiaco, Patrizia ; Boschi, Federica ; Dossena, Maurizia ; Sessarego, Paolo ; Scocchi, Marco ; Arrigoni, Nadia ; Pastoris, Ornella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e292t-181c53a85f3f58523e494ed6284a6a9f5b1dbd7b55d9581d2c687ed0a6482ede3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Amino acids</topic><topic>Biological and medical sciences</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - rehabilitation</topic><topic>Case-Control Studies</topic><topic>Diseases of the osteoarticular system</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Nutritional Status</topic><topic>Plasma</topic><topic>Rehabilitation</topic><topic>Stroke</topic><topic>Stroke - blood</topic><topic>Stroke Rehabilitation</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Tryptophan - blood</topic><topic>Tyrosine - blood</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aquilani, Roberto</creatorcontrib><creatorcontrib>Verri, Manuela</creatorcontrib><creatorcontrib>Iadarola, Paolo</creatorcontrib><creatorcontrib>Arcidiaco, Patrizia</creatorcontrib><creatorcontrib>Boschi, Federica</creatorcontrib><creatorcontrib>Dossena, Maurizia</creatorcontrib><creatorcontrib>Sessarego, Paolo</creatorcontrib><creatorcontrib>Scocchi, Marco</creatorcontrib><creatorcontrib>Arrigoni, Nadia</creatorcontrib><creatorcontrib>Pastoris, Ornella</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of physical medicine and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aquilani, Roberto</au><au>Verri, Manuela</au><au>Iadarola, Paolo</au><au>Arcidiaco, Patrizia</au><au>Boschi, Federica</au><au>Dossena, Maurizia</au><au>Sessarego, Paolo</au><au>Scocchi, Marco</au><au>Arrigoni, Nadia</au><au>Pastoris, Ornella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma precursors of brain catecholaminergic and serotonergic neurotransmitters in rehabilitation patients with ischemic stroke</atitle><jtitle>Archives of physical medicine and rehabilitation</jtitle><addtitle>Arch Phys Med Rehabil</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>85</volume><issue>5</issue><spage>779</spage><epage>784</epage><pages>779-784</pages><issn>0003-9993</issn><eissn>1532-821X</eissn><coden>APMHAI</coden><abstract>Aquilani R, Verri M, Iadarola P, Arcidiaco P, Boschi F, Dossena M, Sessarego P, Scocchi M, Arrigoni N, Pastoris O. Plasma precursors of brain catecholaminergic and serotonergic neurotransmitters in rehabilitation patients with ischemic stroke. Arch Phys Med Rehabil 2004;85:779–84.
To determine levels of plasma amino acid tyrosine and tryptophan, precursors of brain catecholamine and serotonin neurotransmitters, respectively, in rehabilitative patients with ischemic stroke.
Controlled, pre-post analysis, consecutive sample.
Rehabilitation center.
Twenty men with ischemic stroke (age, 68±11.3y) consecutively admitted into rehabilitation 15±10 days (range, 7–28d) after an acute cerebrovascular insult; 15 healthy sedentary subjects (controls 1); and 13 healthy hypoactive individuals who had recently had knee arthroplasty (controls 2). Both control groups were matched to stroke subjects for age, gender, and body weight.
At 8:00
am, after overnight fasting, venous blood samples were drawn from patients to determine plasma tyrosine and tryptophan levels. A nutritional evaluation, including nitrogen balance, was made. The same procedures were repeated after 45 days of rehabilitation. Amino acid data were compared with those obtained from the controls.
Plasma concentrations of amino acids.
Patients with ischemic stroke, on admission, had lower plasma tyrosine concentration than did both controls 1 (
P<.0005) and controls 2 (
P<.001), but a similar tryptophan level. The plasma content of tyrosine was similar between the 2 control groups. After 45 days of rehabilitation, the stroke patients’ tyrosine and tryptophan levels remained virtually unchanged, as did nutritional parameters. Nutritional intakes were adequate to meet body needs but insufficient to correct plasma tyrosine.
Patients experiencing a recent stroke may have low plasma tyrosine levels and, therefore, reduced brain catecholamine formation. It is possible that an imbalance of brain neurotransmitters may occur.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15129403</pmid><doi>10.1016/j.apmr.2003.06.030</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Amino acids Biological and medical sciences Brain Ischemia - blood Brain Ischemia - rehabilitation Case-Control Studies Diseases of the osteoarticular system Humans Male Medical sciences Neurology Nutritional Status Plasma Rehabilitation Stroke Stroke - blood Stroke Rehabilitation Traumas. Diseases due to physical agents Tryptophan - blood Tyrosine - blood Vascular diseases and vascular malformations of the nervous system |
| title | Plasma precursors of brain catecholaminergic and serotonergic neurotransmitters in rehabilitation patients with ischemic stroke |
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