Evaluation of a single-tube multiplex polymerase chain reaction screen for detection of common alpha-thalassemia genotypes in a clinical laboratory

We prospectively compared a single-tube multiplex polymerase chain reaction (PCR) for detecting alpha-thalassemia with our current approach using 452 blood samples. Initial evaluation of 89 specimens revealed sensitivity and specificity, respectively, for the hemoglobin H inclusion body test (HbH pr...

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Veröffentlicht in:	American journal of clinical pathology 2002-07, Vol.118 (1), p.18-24
Hauptverfasser:	JONES, Alana K, POON, Annette
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Thalassemia - diagnosis alpha-Thalassemia - genetics alpha-Thalassemia - urine Biological and medical sciences DNA - analysis DNA Primers - chemistry Erythrocyte Indices - genetics Genotype Hematology Hemoglobin H - urine Humans Investigative techniques, diagnostic techniques (general aspects) Mass Screening Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase Chain Reaction - methods Prospective Studies Sensitivity and Specificity
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