Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors

Gain of chromosome arm 17q is a powerful prognostic factor in neuroblastoma, and the distribution of 17q breakpoints suggests that the dosage of one or more genes in 17q22–23 to 17qter is critical for tumor progression. To identify the smallest region of 17q gain, we used eight probes to map translo...

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Veröffentlicht in:	Genes chromosomes & cancer 2002-08, Vol.34 (4), p.428-436
Hauptverfasser:	Łastowska, Maria, Cotterill, Simon, Bown, Nick, Cullinane, Catherine, Variend, Sadick, Lunec, John, Strachan, Tom, Pearson, Andrew D.J., Jackson, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Chromosome Breakage - genetics Chromosome Mapping Chromosomes, Human, Pair 17 - genetics Genes, erbB-2 - genetics Humans Neoplasm Invasiveness - genetics Neoplasm Staging Neuroblastoma - genetics Neuroblastoma - pathology Prognosis Survival Analysis Tumor Cells, Cultured
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