Inhibition of Enteral Enzymes by Enteroclysis with Nafamostat Mesilate Reduces Neutrophil Activation and Transfusion Requirements after Hemorrhagic Shock

BACKGROUNDThe gut origin of the inflammatory response in trauma patients has been difficult to define. “In vivo” generation of neutrophil-activating factors by gut proteases may be a cause of multiorgan failure after hemorrhagic shock, and can be prevented with the serine protease inhibitor nafamost...

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