CNS blast crisis of chronic myelogenous leukemia in a patient with a major cytogenetic response in bone marrow associated with low levels of imatinib mesylate and its N-desmethylated metabolite in cerebral spinal fluid

Imatinib mesylate (STI571) is a very effective treatment option for Ph(+) chronic myeloid leukemia (CML) in chronic phase. Secondary treatment failures have mostly been observed in patients with advanced stages of disease. We report the case of a patient who unexpectedly experienced blast crisis of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of hematology 2004-06, Vol.83 (6), p.401-402
Hauptverfasser:	Bornhauser, Martin, Jenke, Andreas, Freiberg-Richter, Jens, Radke, Jörgen, Schuler, Ulrich S, Mohr, Brigitte, Ehninger, Gerhard, Schleyer, Eberhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - cerebrospinal fluid Benzamides Blast Crisis - genetics Bone marrow Bone Marrow - pathology Central Nervous System - pathology Female Humans Imatinib Mesylate Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - cerebrospinal fluid Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Middle Aged Piperazines - administration & dosage Piperazines - cerebrospinal fluid Pyrimidines - administration & dosage Pyrimidines - cerebrospinal fluid Remission Induction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!