IgG responses to salivary gland extract of Ixodes ricinus ticks vary inversely with resistance in naturally exposed sheep
Enzyme‐linked immunosorbent assay (ELISA) was used to investigate the antibody responses of control sheep, and sheep naturally exposed to Ixodes ricinus Linné (Acari: Ixodidae) ticks, to salivary gland extract (SGE) proteins of partially fed, adult I. ricinus. Comparisons between responses of contro...
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| Veröffentlicht in: | Medical and veterinary entomology 2002-06, Vol.16 (2), p.186-192 |
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| creator | Ogden, N. H. Casey, A. N. J. Lawrie, C. H. French, N. P. Woldehiwet, Z. Carter, S. D. |
| description | Enzyme‐linked immunosorbent assay (ELISA) was used to investigate the antibody responses of control sheep, and sheep naturally exposed to Ixodes ricinus Linné (Acari: Ixodidae) ticks, to salivary gland extract (SGE) proteins of partially fed, adult I. ricinus. Comparisons between responses of control sheep and naturally infested sheep by Western blot analysis suggested that variations in IgG responses of I. ricinus‐exposed sheep were mostly associated with specific responses to I. ricinus SGE antigens. Sheep IgG responses were positively related to the numbers of adult ticks feeding per sheep at the time samples were collected, were greater during the spring than the autumn periods of I. ricinus activity and were inversely related to sheep resistance to ticks measured by the weights of nymphal I. ricinus that engorged on the sheep. These findings suggest that sheep lose their resistance to ticks due to polarization of a Th1 type response to some tick antigens towards a Th2 type response when sheep are exposed to high, natural tick infestations, or to seasonal conditions of relative nutritional stress. Potential consequences for the epidemiology of tick‐borne diseases are discussed. |
| doi_str_mv | 10.1046/j.1365-2915.2002.00362.x |
| format | Article |
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H. ; Casey, A. N. J. ; Lawrie, C. H. ; French, N. P. ; Woldehiwet, Z. ; Carter, S. D.</creator><creatorcontrib>Ogden, N. H. ; Casey, A. N. J. ; Lawrie, C. H. ; French, N. P. ; Woldehiwet, Z. ; Carter, S. D.</creatorcontrib><description>Enzyme‐linked immunosorbent assay (ELISA) was used to investigate the antibody responses of control sheep, and sheep naturally exposed to Ixodes ricinus Linné (Acari: Ixodidae) ticks, to salivary gland extract (SGE) proteins of partially fed, adult I. ricinus. Comparisons between responses of control sheep and naturally infested sheep by Western blot analysis suggested that variations in IgG responses of I. ricinus‐exposed sheep were mostly associated with specific responses to I. ricinus SGE antigens. Sheep IgG responses were positively related to the numbers of adult ticks feeding per sheep at the time samples were collected, were greater during the spring than the autumn periods of I. ricinus activity and were inversely related to sheep resistance to ticks measured by the weights of nymphal I. ricinus that engorged on the sheep. These findings suggest that sheep lose their resistance to ticks due to polarization of a Th1 type response to some tick antigens towards a Th2 type response when sheep are exposed to high, natural tick infestations, or to seasonal conditions of relative nutritional stress. 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H.</creatorcontrib><creatorcontrib>Casey, A. N. J.</creatorcontrib><creatorcontrib>Lawrie, C. H.</creatorcontrib><creatorcontrib>French, N. P.</creatorcontrib><creatorcontrib>Woldehiwet, Z.</creatorcontrib><creatorcontrib>Carter, S. D.</creatorcontrib><title>IgG responses to salivary gland extract of Ixodes ricinus ticks vary inversely with resistance in naturally exposed sheep</title><title>Medical and veterinary entomology</title><addtitle>Med Vet Entomol</addtitle><description>Enzyme‐linked immunosorbent assay (ELISA) was used to investigate the antibody responses of control sheep, and sheep naturally exposed to Ixodes ricinus Linné (Acari: Ixodidae) ticks, to salivary gland extract (SGE) proteins of partially fed, adult I. ricinus. Comparisons between responses of control sheep and naturally infested sheep by Western blot analysis suggested that variations in IgG responses of I. ricinus‐exposed sheep were mostly associated with specific responses to I. ricinus SGE antigens. Sheep IgG responses were positively related to the numbers of adult ticks feeding per sheep at the time samples were collected, were greater during the spring than the autumn periods of I. ricinus activity and were inversely related to sheep resistance to ticks measured by the weights of nymphal I. ricinus that engorged on the sheep. These findings suggest that sheep lose their resistance to ticks due to polarization of a Th1 type response to some tick antigens towards a Th2 type response when sheep are exposed to high, natural tick infestations, or to seasonal conditions of relative nutritional stress. Potential consequences for the epidemiology of tick‐borne diseases are discussed.</description><subject>Anaplasma</subject><subject>Animals</subject><subject>Antigens - analysis</subject><subject>Blotting, Western - veterinary</subject><subject>Ehrlichia</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>Female</subject><subject>Host-Parasite Interactions</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Ixodes - immunology</subject><subject>Ixodes ricinus</subject><subject>Male</subject><subject>resistance</subject><subject>Salivary Glands - immunology</subject><subject>Seasons</subject><subject>Sheep</subject><subject>Sheep Diseases - immunology</subject><subject>Sheep Diseases - parasitology</subject><subject>T-Lymphocytes, Helper-Inducer</subject><subject>Th1</subject><subject>Th2</subject><subject>tick</subject><subject>Tick Infestations - immunology</subject><subject>Tick Infestations - veterinary</subject><subject>Tick-Borne Diseases - immunology</subject><subject>Tick-Borne Diseases - parasitology</subject><subject>Tick-Borne Diseases - prevention & control</subject><subject>Tissue Extracts - immunology</subject><subject>U.K</subject><issn>0269-283X</issn><issn>1365-2915</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EokPLX0BesUvwI05siQ2MOsOI8lj0wc5ynJvW00wS7KTN_HuczqgsYWXL5zvnyvcghClJKcnyD9uU8lwkTFGRMkJYSgjPWTq9QItn4SVaEJarhEn-6wS9CWFLCC0UY6_RCWWUqILyBdpvbtfYQ-i7NkDAQ4eDadyD8Xt825i2wjAN3tgBdzXeTF0VGe-sa8fIOnsf8BPq2gfwAZo9fnTD3ZznwmBaC1HBrRlGb5oowtR3ASoc7gD6M_SqNk2At8fzFF2tzi-XX5KLH-vN8tNFYjPOWVJXhsvS1koKXktFpbGMgmB5fLSlAlUqCyVIVWYVL6UxglljK6qKnBleWn6K3h9ye9_9HiEMeueChSb-Drox6IIqwpRg_wSpzDKaCxpBeQCt70LwUOveu13cg6ZEz_3orZ5r0HMNeu5HP_Wjp2h9d5wxljuo_hqPhUTg4wF4dA3s_ztYf7s-j5doTw72uH-Ynu3G3-u84IXQN9_Xulitlp9_iq_6kv8BniOxIg</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>Ogden, N. H.</creator><creator>Casey, A. N. J.</creator><creator>Lawrie, C. H.</creator><creator>French, N. P.</creator><creator>Woldehiwet, Z.</creator><creator>Carter, S. D.</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>200206</creationdate><title>IgG responses to salivary gland extract of Ixodes ricinus ticks vary inversely with resistance in naturally exposed sheep</title><author>Ogden, N. H. ; Casey, A. N. J. ; Lawrie, C. H. ; French, N. P. ; Woldehiwet, Z. ; Carter, S. 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H.</creatorcontrib><creatorcontrib>Casey, A. N. J.</creatorcontrib><creatorcontrib>Lawrie, C. H.</creatorcontrib><creatorcontrib>French, N. P.</creatorcontrib><creatorcontrib>Woldehiwet, Z.</creatorcontrib><creatorcontrib>Carter, S. D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Medical and veterinary entomology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogden, N. H.</au><au>Casey, A. N. J.</au><au>Lawrie, C. H.</au><au>French, N. P.</au><au>Woldehiwet, Z.</au><au>Carter, S. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgG responses to salivary gland extract of Ixodes ricinus ticks vary inversely with resistance in naturally exposed sheep</atitle><jtitle>Medical and veterinary entomology</jtitle><addtitle>Med Vet Entomol</addtitle><date>2002-06</date><risdate>2002</risdate><volume>16</volume><issue>2</issue><spage>186</spage><epage>192</epage><pages>186-192</pages><issn>0269-283X</issn><eissn>1365-2915</eissn><abstract>Enzyme‐linked immunosorbent assay (ELISA) was used to investigate the antibody responses of control sheep, and sheep naturally exposed to Ixodes ricinus Linné (Acari: Ixodidae) ticks, to salivary gland extract (SGE) proteins of partially fed, adult I. ricinus. Comparisons between responses of control sheep and naturally infested sheep by Western blot analysis suggested that variations in IgG responses of I. ricinus‐exposed sheep were mostly associated with specific responses to I. ricinus SGE antigens. Sheep IgG responses were positively related to the numbers of adult ticks feeding per sheep at the time samples were collected, were greater during the spring than the autumn periods of I. ricinus activity and were inversely related to sheep resistance to ticks measured by the weights of nymphal I. ricinus that engorged on the sheep. These findings suggest that sheep lose their resistance to ticks due to polarization of a Th1 type response to some tick antigens towards a Th2 type response when sheep are exposed to high, natural tick infestations, or to seasonal conditions of relative nutritional stress. Potential consequences for the epidemiology of tick‐borne diseases are discussed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12109713</pmid><doi>10.1046/j.1365-2915.2002.00362.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Anaplasma Animals Antigens - analysis Blotting, Western - veterinary Ehrlichia Enzyme-Linked Immunosorbent Assay - veterinary Female Host-Parasite Interactions Immunoglobulin G - biosynthesis Ixodes - immunology Ixodes ricinus Male resistance Salivary Glands - immunology Seasons Sheep Sheep Diseases - immunology Sheep Diseases - parasitology T-Lymphocytes, Helper-Inducer Th1 Th2 tick Tick Infestations - immunology Tick Infestations - veterinary Tick-Borne Diseases - immunology Tick-Borne Diseases - parasitology Tick-Borne Diseases - prevention & control Tissue Extracts - immunology U.K |
| title | IgG responses to salivary gland extract of Ixodes ricinus ticks vary inversely with resistance in naturally exposed sheep |
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