Fusarium Infection in Hematopoietic Stem Cell Transplant Recipients
To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allog...
Gespeichert in:
| Veröffentlicht in: | Clinical infectious diseases 2004-05, Vol.38 (9), p.1237-1242 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1242 |
|---|---|
| container_issue | 9 |
| container_start_page | 1237 |
| container_title | Clinical infectious diseases |
| container_volume | 38 |
| creator | Nucci, Marcio Marr, Kieren A. Queiroz-Telles, Flavio Martins, Carlos A. Trabasso, Plínio Costa, Silvia Voltarelli, Julio C. Colombo, Arnaldo L. Imhof, Alexander Pasquini, Ricardo Maiolino, Angelo Cármino, A. Souza Anaissie, Elias |
| description | To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA)-matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis. |
| doi_str_mv | 10.1086/383319 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_71901469</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>4529070</jstor_id><oup_id>10.1086/383319</oup_id><sourcerecordid>4529070</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-288cef8069c7f5499981fa53cfbd1b90530e20f89dadeaff0621d91c175ef7823</originalsourceid><addsrcrecordid>eNqF0E2LFDEQBuAgivuh_gKR9qC31qpOp5McZXSdxQVxZgXxEjLpCmTtL5M06L_flh7WvYinBOrhTepl7BnCGwTVvOWKc9QP2CkKLstGaHy43EGoslZcnbCzlG4AEBWIx-wEBVaS8_qUbS7mZGOY--Jy8ORyGIciDMWWepvHaQyUgyv2mfpiQ11XXEc7pKmzQy525MIUaMjpCXvkbZfo6fE8Z18vPlxvtuXV54-Xm3dXpROoc1kp5cgraLSTXtRaa4XeCu78ocWDBsGBKvBKt7Yl6z00FbYaHUpBXqqKn7PXa-4Ux58zpWz6kNzyLTvQOCcjUQPWjf4vRKlFDeJeootjSpG8mWLobfxtEMyfXs3a6wJfHBPnQ0_tX3YscgGvjsAmZzu_9ORCuueWvaHCxb1c3ThP_37s-WpuUh7jnapFpUHCMi7XcUiZft2NbfxhGsmlMNtv380ePu3e779Is-O30dWgvw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17954052</pqid></control><display><type>article</type><title>Fusarium Infection in Hematopoietic Stem Cell Transplant Recipients</title><source>Jstor Complete Legacy</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Nucci, Marcio ; Marr, Kieren A. ; Queiroz-Telles, Flavio ; Martins, Carlos A. ; Trabasso, Plínio ; Costa, Silvia ; Voltarelli, Julio C. ; Colombo, Arnaldo L. ; Imhof, Alexander ; Pasquini, Ricardo ; Maiolino, Angelo ; Cármino, A. Souza ; Anaissie, Elias</creator><creatorcontrib>Nucci, Marcio ; Marr, Kieren A. ; Queiroz-Telles, Flavio ; Martins, Carlos A. ; Trabasso, Plínio ; Costa, Silvia ; Voltarelli, Julio C. ; Colombo, Arnaldo L. ; Imhof, Alexander ; Pasquini, Ricardo ; Maiolino, Angelo ; Cármino, A. Souza ; Anaissie, Elias</creatorcontrib><description>To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA)-matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/383319</identifier><identifier>PMID: 15127334</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Aged ; Aspergillosis ; Biological and medical sciences ; Blood ; Brazil - epidemiology ; Child ; Child, Preschool ; Female ; Fusariosis ; Fusarium ; Graft vs host disease ; Hematologic and hematopoietic diseases ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Humans ; Infections ; Major Articles ; Male ; Medical sciences ; Middle Aged ; Mud ; Mycoses - epidemiology ; Mycoses - etiology ; Mycoses - microbiology ; Neutropenia ; Opportunistic Infections - epidemiology ; Opportunistic Infections - etiology ; Other diseases. Hematologic involvement in other diseases ; Transplantation ; United States - epidemiology</subject><ispartof>Clinical infectious diseases, 2004-05, Vol.38 (9), p.1237-1242</ispartof><rights>Copyright 2004 The Infectious Diseases Society of America</rights><rights>2004 by the Infectious Diseases Society of America 2004</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-288cef8069c7f5499981fa53cfbd1b90530e20f89dadeaff0621d91c175ef7823</citedby><cites>FETCH-LOGICAL-c519t-288cef8069c7f5499981fa53cfbd1b90530e20f89dadeaff0621d91c175ef7823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4529070$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4529070$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15806021$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15127334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nucci, Marcio</creatorcontrib><creatorcontrib>Marr, Kieren A.</creatorcontrib><creatorcontrib>Queiroz-Telles, Flavio</creatorcontrib><creatorcontrib>Martins, Carlos A.</creatorcontrib><creatorcontrib>Trabasso, Plínio</creatorcontrib><creatorcontrib>Costa, Silvia</creatorcontrib><creatorcontrib>Voltarelli, Julio C.</creatorcontrib><creatorcontrib>Colombo, Arnaldo L.</creatorcontrib><creatorcontrib>Imhof, Alexander</creatorcontrib><creatorcontrib>Pasquini, Ricardo</creatorcontrib><creatorcontrib>Maiolino, Angelo</creatorcontrib><creatorcontrib>Cármino, A. Souza</creatorcontrib><creatorcontrib>Anaissie, Elias</creatorcontrib><title>Fusarium Infection in Hematopoietic Stem Cell Transplant Recipients</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA)-matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aspergillosis</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Brazil - epidemiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fusariosis</subject><subject>Fusarium</subject><subject>Graft vs host disease</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Infections</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mud</subject><subject>Mycoses - epidemiology</subject><subject>Mycoses - etiology</subject><subject>Mycoses - microbiology</subject><subject>Neutropenia</subject><subject>Opportunistic Infections - epidemiology</subject><subject>Opportunistic Infections - etiology</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Transplantation</subject><subject>United States - epidemiology</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E2LFDEQBuAgivuh_gKR9qC31qpOp5McZXSdxQVxZgXxEjLpCmTtL5M06L_flh7WvYinBOrhTepl7BnCGwTVvOWKc9QP2CkKLstGaHy43EGoslZcnbCzlG4AEBWIx-wEBVaS8_qUbS7mZGOY--Jy8ORyGIciDMWWepvHaQyUgyv2mfpiQ11XXEc7pKmzQy525MIUaMjpCXvkbZfo6fE8Z18vPlxvtuXV54-Xm3dXpROoc1kp5cgraLSTXtRaa4XeCu78ocWDBsGBKvBKt7Yl6z00FbYaHUpBXqqKn7PXa-4Ux58zpWz6kNzyLTvQOCcjUQPWjf4vRKlFDeJeootjSpG8mWLobfxtEMyfXs3a6wJfHBPnQ0_tX3YscgGvjsAmZzu_9ORCuueWvaHCxb1c3ThP_37s-WpuUh7jnapFpUHCMi7XcUiZft2NbfxhGsmlMNtv380ePu3e779Is-O30dWgvw</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Nucci, Marcio</creator><creator>Marr, Kieren A.</creator><creator>Queiroz-Telles, Flavio</creator><creator>Martins, Carlos A.</creator><creator>Trabasso, Plínio</creator><creator>Costa, Silvia</creator><creator>Voltarelli, Julio C.</creator><creator>Colombo, Arnaldo L.</creator><creator>Imhof, Alexander</creator><creator>Pasquini, Ricardo</creator><creator>Maiolino, Angelo</creator><creator>Cármino, A. Souza</creator><creator>Anaissie, Elias</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Fusarium Infection in Hematopoietic Stem Cell Transplant Recipients</title><author>Nucci, Marcio ; Marr, Kieren A. ; Queiroz-Telles, Flavio ; Martins, Carlos A. ; Trabasso, Plínio ; Costa, Silvia ; Voltarelli, Julio C. ; Colombo, Arnaldo L. ; Imhof, Alexander ; Pasquini, Ricardo ; Maiolino, Angelo ; Cármino, A. Souza ; Anaissie, Elias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-288cef8069c7f5499981fa53cfbd1b90530e20f89dadeaff0621d91c175ef7823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aspergillosis</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Brazil - epidemiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fusariosis</topic><topic>Fusarium</topic><topic>Graft vs host disease</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Infections</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mud</topic><topic>Mycoses - epidemiology</topic><topic>Mycoses - etiology</topic><topic>Mycoses - microbiology</topic><topic>Neutropenia</topic><topic>Opportunistic Infections - epidemiology</topic><topic>Opportunistic Infections - etiology</topic><topic>Other diseases. Hematologic involvement in other diseases</topic><topic>Transplantation</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nucci, Marcio</creatorcontrib><creatorcontrib>Marr, Kieren A.</creatorcontrib><creatorcontrib>Queiroz-Telles, Flavio</creatorcontrib><creatorcontrib>Martins, Carlos A.</creatorcontrib><creatorcontrib>Trabasso, Plínio</creatorcontrib><creatorcontrib>Costa, Silvia</creatorcontrib><creatorcontrib>Voltarelli, Julio C.</creatorcontrib><creatorcontrib>Colombo, Arnaldo L.</creatorcontrib><creatorcontrib>Imhof, Alexander</creatorcontrib><creatorcontrib>Pasquini, Ricardo</creatorcontrib><creatorcontrib>Maiolino, Angelo</creatorcontrib><creatorcontrib>Cármino, A. Souza</creatorcontrib><creatorcontrib>Anaissie, Elias</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nucci, Marcio</au><au>Marr, Kieren A.</au><au>Queiroz-Telles, Flavio</au><au>Martins, Carlos A.</au><au>Trabasso, Plínio</au><au>Costa, Silvia</au><au>Voltarelli, Julio C.</au><au>Colombo, Arnaldo L.</au><au>Imhof, Alexander</au><au>Pasquini, Ricardo</au><au>Maiolino, Angelo</au><au>Cármino, A. Souza</au><au>Anaissie, Elias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fusarium Infection in Hematopoietic Stem Cell Transplant Recipients</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>38</volume><issue>9</issue><spage>1237</spage><epage>1242</epage><pages>1237-1242</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA)-matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>15127334</pmid><doi>10.1086/383319</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2004-05, Vol.38 (9), p.1237-1242 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71901469 |
| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Aspergillosis Biological and medical sciences Blood Brazil - epidemiology Child Child, Preschool Female Fusariosis Fusarium Graft vs host disease Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans Infections Major Articles Male Medical sciences Middle Aged Mud Mycoses - epidemiology Mycoses - etiology Mycoses - microbiology Neutropenia Opportunistic Infections - epidemiology Opportunistic Infections - etiology Other diseases. Hematologic involvement in other diseases Transplantation United States - epidemiology |
| title | Fusarium Infection in Hematopoietic Stem Cell Transplant Recipients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T01%3A50%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fusarium%20Infection%20in%20Hematopoietic%20Stem%20Cell%20Transplant%20Recipients&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Nucci,%20Marcio&rft.date=2004-05-01&rft.volume=38&rft.issue=9&rft.spage=1237&rft.epage=1242&rft.pages=1237-1242&rft.issn=1058-4838&rft.eissn=1537-6591&rft.coden=CIDIEL&rft_id=info:doi/10.1086/383319&rft_dat=%3Cjstor_proqu%3E4529070%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17954052&rft_id=info:pmid/15127334&rft_jstor_id=4529070&rft_oup_id=10.1086/383319&rfr_iscdi=true |