A solid-phase approach towards the synthesis of PDE5 inhibitors

PDE5 inhibitors based upon the xanthine scaffold 8 have been expediently synthesized using a solid-phase route. Attachment of the xanthine scaffold 8 using the Rink chloride linker 4 and N-1 functionalization using Mitsunobu chemistry is described. A library of compounds was produced in multi-millig...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-08, Vol.12 (15), p.1973-1976
Hauptverfasser:	Beer, David, Bhalay, Gurdip, Dunstan, Andrew, Glen, Angela, Haberthuer, Sandra, Moser, Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-GMP Phosphodiesterases Biological and medical sciences Combinatorial Chemistry Techniques Cyclic Nucleotide Phosphodiesterases, Type 5 Databases, Factual Genital system. Reproduction Indicators and Reagents - chemistry Medical sciences Nuclear Magnetic Resonance, Biomolecular Pharmacology. Drug treatments Phosphodiesterase Inhibitors - chemical synthesis Phosphodiesterase Inhibitors - pharmacology Phosphoric Diester Hydrolases - metabolism Structure-Activity Relationship Xanthine - chemistry
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