Biliverdin Reductase, a Novel Regulator for Induction of Activating Transcription Factor-2 and Heme Oxygenase-1

Biliverdin IXÎ± reductase (BVR) catalyzes reduction of the HO activity product, biliverdin, to bilirubin. hBVR is a serine/threonine kinase that contains a bZip domain. Presently, regulation of gene expression by hBVR was examined. 293A cells were infected with adenovirusdoxycycline (Ad-Dox)-inducib...

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Veröffentlicht in:	The Journal of biological chemistry 2004-05, Vol.279 (19), p.19916-19923
Hauptverfasser:	Kravets, Anatoliy, Hu, Zhenbo, Miralem, Tihomir, Torno, Michael D, Maines, Mahin D
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 2 Adenoviridae - genetics Amino Acid Motifs Blotting, Northern Blotting, Western Cell Line Cell Nucleus - metabolism Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Dimerization DNA, Complementary - metabolism Doxycycline - pharmacology Enzyme-Linked Immunosorbent Assay Gene Expression Regulation, Enzymologic Heme Oxygenase (Decyclizing) - metabolism Heme Oxygenase-1 Humans Luciferases - metabolism Membrane Proteins Oligonucleotide Array Sequence Analysis Oligonucleotides - chemistry Oxidoreductases Acting on CH-CH Group Donors - physiology Promoter Regions, Genetic Protein Biosynthesis Protein Structure, Tertiary Proto-Oncogene Proteins c-jun - metabolism RNA, Messenger - metabolism Signal Transduction Time Factors Transcription Factors - metabolism Transcriptional Activation Transfection Up-Regulation
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