Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia
Pulmonary alveolar proteinosis (PAP) is a heterogeneous disease that occasionally develops with hematological malignancy. However, PAP in association with hematopoietic stem cell transplantation is quite rare. Here we present the first report of a patient who developed PAP after cord blood transplan...
Gespeichert in:
| Veröffentlicht in: | American journal of hematology 2002-06, Vol.70 (2), p.154-157 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 157 |
|---|---|
| container_issue | 2 |
| container_start_page | 154 |
| container_title | American journal of hematology |
| container_volume | 70 |
| creator | Tomonari, Akira Shirafuji, Naoki Iseki, Tohru Ooi, Jun Nagayama, Hitomi Masunaga, Atsuko Tojo, Arinobu Tani, Kenzaburo Asano, Shigetaka |
| description | Pulmonary alveolar proteinosis (PAP) is a heterogeneous disease that occasionally develops with hematological malignancy. However, PAP in association with hematopoietic stem cell transplantation is quite rare. Here we present the first report of a patient who developed PAP after cord blood transplantation (CBT). A 45‐year‐old female with AML underwent unrelated CBT. On day +2 after CBT she developed congestive heart failure with diffuse alveolar infiltrates in the bilateral lungs. Despite treatment, the alveolar infiltrates further increased with progression of multiple organ failure (MOF). She died from MOF before hematopoietic recovery on day +27. Post‐mortem study revealed that massive amorphous materials positive for periodic acid‐Schiff stain filled in the pulmonary alveoli. These findings led to a diagnosis of PAP. The bone marrow was hypocellular without the leukemic cells. The impaired immunity during the period of leukopenia as well as the impaired clearance of surfactant proteins might contribute to the development of PAP. Am. J. Hematol. 70:154–157, 2002.© 2002 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajh.10107 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71897862</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71897862</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4527-16e90bc0f677edd4d66ec61149e6922d865f06713120a9cb22a13aeacacdd4793</originalsourceid><addsrcrecordid>eNp1kMFOGzEQhi1URELKoS9Q-dJKHAIeb2KvjxEqpBUSFzivZu1Z1dS7DvZuUd4el0Ti1NP8h08z_3yMfQFxBULIa3z-XQIIfcLmIIxa1motP7G5qBSULMyMnef8LATAqhZnbAYSALQRc9Zv7MvkEzm-m0IfB0x7juEvxYCJ71IcyQ8x-8yxGynxqW998BYDtzE53oYYHR8TDnkXcBhx9HHgXUwc7TQS7_cUonc80PSHeo-f2WmHIdPFcS7Y0-2Px5vt8v7h7ufN5n5pV2upl6DIiNaKTmlNzq2cUmRVKW9IGSldea8TSkMFUqCxrZQIFRJatIXWplqw74e95YOXifLY9D5bCqUjxSk3GmqjayULeHkAbYo5J-qaXfJ9kdCAaP65bYrb5t1tYb8el05tT-6DPMoswLcjgLko6ooW6_MHV6m6rkAV7vrAvfpA-_9fbDa_tofTb0xXkjk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71897862</pqid></control><display><type>article</type><title>Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Tomonari, Akira ; Shirafuji, Naoki ; Iseki, Tohru ; Ooi, Jun ; Nagayama, Hitomi ; Masunaga, Atsuko ; Tojo, Arinobu ; Tani, Kenzaburo ; Asano, Shigetaka</creator><creatorcontrib>Tomonari, Akira ; Shirafuji, Naoki ; Iseki, Tohru ; Ooi, Jun ; Nagayama, Hitomi ; Masunaga, Atsuko ; Tojo, Arinobu ; Tani, Kenzaburo ; Asano, Shigetaka</creatorcontrib><description>Pulmonary alveolar proteinosis (PAP) is a heterogeneous disease that occasionally develops with hematological malignancy. However, PAP in association with hematopoietic stem cell transplantation is quite rare. Here we present the first report of a patient who developed PAP after cord blood transplantation (CBT). A 45‐year‐old female with AML underwent unrelated CBT. On day +2 after CBT she developed congestive heart failure with diffuse alveolar infiltrates in the bilateral lungs. Despite treatment, the alveolar infiltrates further increased with progression of multiple organ failure (MOF). She died from MOF before hematopoietic recovery on day +27. Post‐mortem study revealed that massive amorphous materials positive for periodic acid‐Schiff stain filled in the pulmonary alveoli. These findings led to a diagnosis of PAP. The bone marrow was hypocellular without the leukemic cells. The impaired immunity during the period of leukopenia as well as the impaired clearance of surfactant proteins might contribute to the development of PAP. Am. J. Hematol. 70:154–157, 2002.© 2002 Wiley‐Liss, Inc.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.10107</identifier><identifier>PMID: 12111790</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Acute Disease ; acute myeloid leukemia ; Biological and medical sciences ; Bone Marrow Cells - pathology ; cord blood transplantation ; Fatal Outcome ; Female ; Heart Failure - etiology ; Hematologic and hematopoietic diseases ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Karyotyping ; Leukemia, Myeloid, Acute - therapy ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Middle Aged ; Multiple Organ Failure - etiology ; Pneumology ; pulmonary alveolar proteinosis ; Pulmonary Alveolar Proteinosis - etiology ; Respiratory system : syndromes and miscellaneous diseases</subject><ispartof>American journal of hematology, 2002-06, Vol.70 (2), p.154-157</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4527-16e90bc0f677edd4d66ec61149e6922d865f06713120a9cb22a13aeacacdd4793</citedby><cites>FETCH-LOGICAL-c4527-16e90bc0f677edd4d66ec61149e6922d865f06713120a9cb22a13aeacacdd4793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajh.10107$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajh.10107$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13688316$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12111790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomonari, Akira</creatorcontrib><creatorcontrib>Shirafuji, Naoki</creatorcontrib><creatorcontrib>Iseki, Tohru</creatorcontrib><creatorcontrib>Ooi, Jun</creatorcontrib><creatorcontrib>Nagayama, Hitomi</creatorcontrib><creatorcontrib>Masunaga, Atsuko</creatorcontrib><creatorcontrib>Tojo, Arinobu</creatorcontrib><creatorcontrib>Tani, Kenzaburo</creatorcontrib><creatorcontrib>Asano, Shigetaka</creatorcontrib><title>Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>Pulmonary alveolar proteinosis (PAP) is a heterogeneous disease that occasionally develops with hematological malignancy. However, PAP in association with hematopoietic stem cell transplantation is quite rare. Here we present the first report of a patient who developed PAP after cord blood transplantation (CBT). A 45‐year‐old female with AML underwent unrelated CBT. On day +2 after CBT she developed congestive heart failure with diffuse alveolar infiltrates in the bilateral lungs. Despite treatment, the alveolar infiltrates further increased with progression of multiple organ failure (MOF). She died from MOF before hematopoietic recovery on day +27. Post‐mortem study revealed that massive amorphous materials positive for periodic acid‐Schiff stain filled in the pulmonary alveoli. These findings led to a diagnosis of PAP. The bone marrow was hypocellular without the leukemic cells. The impaired immunity during the period of leukopenia as well as the impaired clearance of surfactant proteins might contribute to the development of PAP. Am. J. Hematol. 70:154–157, 2002.© 2002 Wiley‐Liss, Inc.</description><subject>Acute Disease</subject><subject>acute myeloid leukemia</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells - pathology</subject><subject>cord blood transplantation</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Heart Failure - etiology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leukemia, Myeloid, Acute - therapy</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Organ Failure - etiology</subject><subject>Pneumology</subject><subject>pulmonary alveolar proteinosis</subject><subject>Pulmonary Alveolar Proteinosis - etiology</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFOGzEQhi1URELKoS9Q-dJKHAIeb2KvjxEqpBUSFzivZu1Z1dS7DvZuUd4el0Ti1NP8h08z_3yMfQFxBULIa3z-XQIIfcLmIIxa1motP7G5qBSULMyMnef8LATAqhZnbAYSALQRc9Zv7MvkEzm-m0IfB0x7juEvxYCJ71IcyQ8x-8yxGynxqW998BYDtzE53oYYHR8TDnkXcBhx9HHgXUwc7TQS7_cUonc80PSHeo-f2WmHIdPFcS7Y0-2Px5vt8v7h7ufN5n5pV2upl6DIiNaKTmlNzq2cUmRVKW9IGSldea8TSkMFUqCxrZQIFRJatIXWplqw74e95YOXifLY9D5bCqUjxSk3GmqjayULeHkAbYo5J-qaXfJ9kdCAaP65bYrb5t1tYb8el05tT-6DPMoswLcjgLko6ooW6_MHV6m6rkAV7vrAvfpA-_9fbDa_tofTb0xXkjk</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>Tomonari, Akira</creator><creator>Shirafuji, Naoki</creator><creator>Iseki, Tohru</creator><creator>Ooi, Jun</creator><creator>Nagayama, Hitomi</creator><creator>Masunaga, Atsuko</creator><creator>Tojo, Arinobu</creator><creator>Tani, Kenzaburo</creator><creator>Asano, Shigetaka</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200206</creationdate><title>Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia</title><author>Tomonari, Akira ; Shirafuji, Naoki ; Iseki, Tohru ; Ooi, Jun ; Nagayama, Hitomi ; Masunaga, Atsuko ; Tojo, Arinobu ; Tani, Kenzaburo ; Asano, Shigetaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4527-16e90bc0f677edd4d66ec61149e6922d865f06713120a9cb22a13aeacacdd4793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute Disease</topic><topic>acute myeloid leukemia</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells - pathology</topic><topic>cord blood transplantation</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Heart Failure - etiology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leukemia, Myeloid, Acute - therapy</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Organ Failure - etiology</topic><topic>Pneumology</topic><topic>pulmonary alveolar proteinosis</topic><topic>Pulmonary Alveolar Proteinosis - etiology</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomonari, Akira</creatorcontrib><creatorcontrib>Shirafuji, Naoki</creatorcontrib><creatorcontrib>Iseki, Tohru</creatorcontrib><creatorcontrib>Ooi, Jun</creatorcontrib><creatorcontrib>Nagayama, Hitomi</creatorcontrib><creatorcontrib>Masunaga, Atsuko</creatorcontrib><creatorcontrib>Tojo, Arinobu</creatorcontrib><creatorcontrib>Tani, Kenzaburo</creatorcontrib><creatorcontrib>Asano, Shigetaka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomonari, Akira</au><au>Shirafuji, Naoki</au><au>Iseki, Tohru</au><au>Ooi, Jun</au><au>Nagayama, Hitomi</au><au>Masunaga, Atsuko</au><au>Tojo, Arinobu</au><au>Tani, Kenzaburo</au><au>Asano, Shigetaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>2002-06</date><risdate>2002</risdate><volume>70</volume><issue>2</issue><spage>154</spage><epage>157</epage><pages>154-157</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>Pulmonary alveolar proteinosis (PAP) is a heterogeneous disease that occasionally develops with hematological malignancy. However, PAP in association with hematopoietic stem cell transplantation is quite rare. Here we present the first report of a patient who developed PAP after cord blood transplantation (CBT). A 45‐year‐old female with AML underwent unrelated CBT. On day +2 after CBT she developed congestive heart failure with diffuse alveolar infiltrates in the bilateral lungs. Despite treatment, the alveolar infiltrates further increased with progression of multiple organ failure (MOF). She died from MOF before hematopoietic recovery on day +27. Post‐mortem study revealed that massive amorphous materials positive for periodic acid‐Schiff stain filled in the pulmonary alveoli. These findings led to a diagnosis of PAP. The bone marrow was hypocellular without the leukemic cells. The impaired immunity during the period of leukopenia as well as the impaired clearance of surfactant proteins might contribute to the development of PAP. Am. J. Hematol. 70:154–157, 2002.© 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12111790</pmid><doi>10.1002/ajh.10107</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0361-8609 |
| ispartof | American journal of hematology, 2002-06, Vol.70 (2), p.154-157 |
| issn | 0361-8609 1096-8652 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71897862 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute Disease acute myeloid leukemia Biological and medical sciences Bone Marrow Cells - pathology cord blood transplantation Fatal Outcome Female Heart Failure - etiology Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - adverse effects Humans Karyotyping Leukemia, Myeloid, Acute - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Multiple Organ Failure - etiology Pneumology pulmonary alveolar proteinosis Pulmonary Alveolar Proteinosis - etiology Respiratory system : syndromes and miscellaneous diseases |
| title | Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T02%3A07%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acquired%20pulmonary%20alveolar%20proteinosis%20after%20umbilical%20cord%20blood%20transplantation%20for%20acute%20myeloid%20leukemia&rft.jtitle=American%20journal%20of%20hematology&rft.au=Tomonari,%20Akira&rft.date=2002-06&rft.volume=70&rft.issue=2&rft.spage=154&rft.epage=157&rft.pages=154-157&rft.issn=0361-8609&rft.eissn=1096-8652&rft.coden=AJHEDD&rft_id=info:doi/10.1002/ajh.10107&rft_dat=%3Cproquest_cross%3E71897862%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71897862&rft_id=info:pmid/12111790&rfr_iscdi=true |