Enhanced Gene Transfer to Mouse Dendritic Cells Using Adenoviral Vectors Coated with a Novel Adapter Molecule

Adenovirus (Ad)-mediated transduction of dendritic cells (DC) is inefficient because of the lack of the primary Ad receptor, CAR. DC infection with Ad targeted to the CD40 results in increased gene transfer. The current report describes further development of the CD40-targeting approach using an ada...

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Veröffentlicht in:	Molecular therapy 2004-05, Vol.9 (5), p.712-720
Hauptverfasser:	Pereboev, Alexander V, Nagle, Jill M, Shakhmatov, Mikhail A, Triozzi, Pierre L, Matthews, Qiana L, Kawakami, Yosuke, Curiel, David T, Blackwell, Jerry L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adenoviridae - genetics Adenoviruses Animals Antibodies Bone marrow Bone Marrow Cells - cytology CD4-Positive T-Lymphocytes - immunology CD40 Ligand - genetics CD40 Ligand - metabolism CD8-Positive T-Lymphocytes - immunology Cell Line Coxsackie and Adenovirus Receptor-Like Membrane Protein Dendritic cells Dendritic Cells - cytology Dendritic Cells - metabolism Gene Expression Gene therapy Genetic Vectors Humans Immunotherapy Infectious diseases Interleukin-12 - genetics Ligands Medical research Mice Mice, Inbred BALB C Receptors, Virus - genetics Receptors, Virus - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA, Messenger - analysis Transduction, Genetic - methods Vectors (Biology)
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