Endogenous sex hormones and progression of carotid atherosclerosis in elderly men
The burden of atherosclerosis especially afflicts the increasing older segment of the population. Recent evidence has emphasized a protective role of endogenous sex hormones in the development of atherosclerosis in aging men. We studied the association between endogenous sex hormones and progression...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2004-05, Vol.109 (17), p.2074-2079 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | MULLER, Majon VAN DEN BELD, Annewieke W BOTS, Michiel L GROBBEE, Diederick E LAMBERTS, Steven W. J VAN DER SCHOUW, Yvonne T |
| description | The burden of atherosclerosis especially afflicts the increasing older segment of the population. Recent evidence has emphasized a protective role of endogenous sex hormones in the development of atherosclerosis in aging men.
We studied the association between endogenous sex hormones and progression of atherosclerosis in 195 independently living elderly men. Participants underwent measurements of carotid intima-media thickness (IMT) at baseline in 1996 and again in 2000. At baseline, serum concentrations of testosterone (total and free) and estradiol (total and free E2) were measured. Serum free testosterone concentrations were inversely related to the mean progression of IMT of the common carotid artery after adjustment for age (beta=-3.57; 95% CI, -6.34 to -0.80). Higher serum total and free E2 levels were related to progression of IMT of the common carotid artery after adjustment for age (beta=0.38; 95% CI, -0.11 to 0.86; and beta=0.018; 95% CI, -0.002 to 0.038, respectively). These associations were independent of body mass index, waist-to-hip ratio, presence of hypertension and diabetes, smoking, and serum cholesterol levels
Low free testosterone levels were related to IMT of the common carotid artery in elderly men independently of cardiovascular risk factors. |
| doi_str_mv | 10.1161/01.cir.0000125854.51637.06 |
| format | Article |
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We studied the association between endogenous sex hormones and progression of atherosclerosis in 195 independently living elderly men. Participants underwent measurements of carotid intima-media thickness (IMT) at baseline in 1996 and again in 2000. At baseline, serum concentrations of testosterone (total and free) and estradiol (total and free E2) were measured. Serum free testosterone concentrations were inversely related to the mean progression of IMT of the common carotid artery after adjustment for age (beta=-3.57; 95% CI, -6.34 to -0.80). Higher serum total and free E2 levels were related to progression of IMT of the common carotid artery after adjustment for age (beta=0.38; 95% CI, -0.11 to 0.86; and beta=0.018; 95% CI, -0.002 to 0.038, respectively). These associations were independent of body mass index, waist-to-hip ratio, presence of hypertension and diabetes, smoking, and serum cholesterol levels
Low free testosterone levels were related to IMT of the common carotid artery in elderly men independently of cardiovascular risk factors.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.cir.0000125854.51637.06</identifier><identifier>PMID: 15096452</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Carotid Artery Diseases - blood ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - epidemiology ; Carotid Artery, Common - diagnostic imaging ; Disease Progression ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Estradiol - blood ; Humans ; Male ; Medical sciences ; Prospective Studies ; Risk Factors ; Testosterone - blood ; Tunica Intima - diagnostic imaging ; Tunica Media - diagnostic imaging ; Ultrasonography</subject><ispartof>Circulation (New York, N.Y.), 2004-05, Vol.109 (17), p.2074-2079</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-b25963f940190b3791fc6d35b948ac07ff368d0ad1efc8f1e6db3580ca0118073</citedby><cites>FETCH-LOGICAL-c563t-b25963f940190b3791fc6d35b948ac07ff368d0ad1efc8f1e6db3580ca0118073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15835553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15096452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MULLER, Majon</creatorcontrib><creatorcontrib>VAN DEN BELD, Annewieke W</creatorcontrib><creatorcontrib>BOTS, Michiel L</creatorcontrib><creatorcontrib>GROBBEE, Diederick E</creatorcontrib><creatorcontrib>LAMBERTS, Steven W. J</creatorcontrib><creatorcontrib>VAN DER SCHOUW, Yvonne T</creatorcontrib><title>Endogenous sex hormones and progression of carotid atherosclerosis in elderly men</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>The burden of atherosclerosis especially afflicts the increasing older segment of the population. Recent evidence has emphasized a protective role of endogenous sex hormones in the development of atherosclerosis in aging men.
We studied the association between endogenous sex hormones and progression of atherosclerosis in 195 independently living elderly men. Participants underwent measurements of carotid intima-media thickness (IMT) at baseline in 1996 and again in 2000. At baseline, serum concentrations of testosterone (total and free) and estradiol (total and free E2) were measured. Serum free testosterone concentrations were inversely related to the mean progression of IMT of the common carotid artery after adjustment for age (beta=-3.57; 95% CI, -6.34 to -0.80). Higher serum total and free E2 levels were related to progression of IMT of the common carotid artery after adjustment for age (beta=0.38; 95% CI, -0.11 to 0.86; and beta=0.018; 95% CI, -0.002 to 0.038, respectively). These associations were independent of body mass index, waist-to-hip ratio, presence of hypertension and diabetes, smoking, and serum cholesterol levels
Low free testosterone levels were related to IMT of the common carotid artery in elderly men independently of cardiovascular risk factors.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Artery Diseases - blood</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Artery, Common - diagnostic imaging</subject><subject>Disease Progression</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Estradiol - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Testosterone - blood</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Ultrasonography</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkNtKAzEQQIMoWqu_IEHQt10zm0121zcp9QIFUfQ5ZHNpI7uJJi3o35tqQedhhsCZycxB6BxICcDhikCpXCxJDqhYy-qSAadNSfgemgCr6qJmtNtHkwx0RUOr6ggdp_SWnxljh-gIGOl4zaoJepp7HZbGh03CyXziVYhj8CZh6TV-j2EZTUoueBwsVjKGtdNYrlcmhqSGbXYJO4_NoE0cvvBo_Ak6sHJI5nRXp-j1dv4yuy8Wj3cPs5tFoRin66KvWMep7WoCHelp04FVXFPWd3UrFWmspbzVRGowVrUWDNc9ZS1RkgC0pKFTdPk7N2_5sTFpLUaXlBkG6U2-RjTQ5huzmCm6_gVVXjdFY8V7dKOMXwKI2AoVBMTs4Vn8CRU_QgXZNp_tftn0o9F_rTuDGbjYATIpOdgovXLpH9dSxhil38uFf6Q</recordid><startdate>20040504</startdate><enddate>20040504</enddate><creator>MULLER, Majon</creator><creator>VAN DEN BELD, Annewieke W</creator><creator>BOTS, Michiel L</creator><creator>GROBBEE, Diederick E</creator><creator>LAMBERTS, Steven W. 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Miscellaneous</topic><topic>Estradiol - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Testosterone - blood</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Tunica Media - diagnostic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MULLER, Majon</creatorcontrib><creatorcontrib>VAN DEN BELD, Annewieke W</creatorcontrib><creatorcontrib>BOTS, Michiel L</creatorcontrib><creatorcontrib>GROBBEE, Diederick E</creatorcontrib><creatorcontrib>LAMBERTS, Steven W. 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We studied the association between endogenous sex hormones and progression of atherosclerosis in 195 independently living elderly men. Participants underwent measurements of carotid intima-media thickness (IMT) at baseline in 1996 and again in 2000. At baseline, serum concentrations of testosterone (total and free) and estradiol (total and free E2) were measured. Serum free testosterone concentrations were inversely related to the mean progression of IMT of the common carotid artery after adjustment for age (beta=-3.57; 95% CI, -6.34 to -0.80). Higher serum total and free E2 levels were related to progression of IMT of the common carotid artery after adjustment for age (beta=0.38; 95% CI, -0.11 to 0.86; and beta=0.018; 95% CI, -0.002 to 0.038, respectively). These associations were independent of body mass index, waist-to-hip ratio, presence of hypertension and diabetes, smoking, and serum cholesterol levels
Low free testosterone levels were related to IMT of the common carotid artery in elderly men independently of cardiovascular risk factors.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15096452</pmid><doi>10.1161/01.cir.0000125854.51637.06</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Artery Diseases - blood Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - epidemiology Carotid Artery, Common - diagnostic imaging Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Estradiol - blood Humans Male Medical sciences Prospective Studies Risk Factors Testosterone - blood Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Ultrasonography |
| title | Endogenous sex hormones and progression of carotid atherosclerosis in elderly men |
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