Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death

Human atherosclerotic lesions contain elevated levels of urokinase plasminogen activator (uPA), expressed predominantly by macrophages. To test the hypothesis that macrophage-expressed uPA contributes to the progression and complications of atherosclerosis, we generated transgenic mice with macropha...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2004-05, Vol.109 (17), p.2129-2135
Hauptverfasser:	COZEN, Aaron E, MORIWAKI, Hideaki, KREMEN, Michal, DEYOUNG, Mary Beth, DICHEK, Helén L, SLEZICKI, Katherine I, YOUNG, Stephen G, VENIANT, Murielle, DICHEK, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Diseases - enzymology Aortic Diseases - genetics Aortic Diseases - pathology Apolipoproteins E - deficiency Apolipoproteins E - genetics Arteriosclerosis - blood Arteriosclerosis - enzymology Arteriosclerosis - genetics Arteriosclerosis - pathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cholesterol - blood Coronary Disease - enzymology Coronary Disease - genetics Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Enhancer Elements, Genetic - genetics Female Genes, Synthetic Heat-Shock Proteins - genetics Humans Longevity - genetics Macrophages - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Myocardial Infarction - enzymology Myocardial Infarction - genetics Promoter Regions, Genetic - genetics Receptors, Immunologic - genetics Recombinant Fusion Proteins - physiology Scavenger Receptors, Class A Transgenes Triglycerides - blood Urokinase-Type Plasminogen Activator - genetics Urokinase-Type Plasminogen Activator - physiology
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