An Improved Method for the Synthesis of Cellulose Membrane-Bound Peptides with Free C Termini Is Useful for PDZ Domain Binding Studies

SPOT synthesis permits parallel synthesis and screening of thousands of cellulose membrane-bound peptides to study protein-protein interactions in a proteomic context. Recognition of C-terminal residues is one of the most common binding features of PDZ domains. Unfortunately, most solid support-boun...

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