Enhanced mRNA expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in breast carcinomas is correlated with adverse prognosis

Tissue inhibitor of metalloproteinase‐1 (TIMP‐1) has emerged as a multifunctional protein with the contrasting activities of inhibiting tissue‐degrading enzymes and promoting cellular growth. In an attempt to elucidate the clinical significance of TIMP‐1 in breast cancer, the expression of TIMP‐1 mR...

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Veröffentlicht in:	The Journal of pathology 2002-07, Vol.197 (3), p.307-313
Hauptverfasser:	Nakopoulou, Lydia, Giannopoulou, Ioanna, Stefanaki, Kalliopi, Panayotopoulou, Effie, Tsirmpa, Ioanna, Alexandrou, Paraskevi, Mavrommatis, John, Katsarou, Sophia, Davaris, Panagiotis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers - analysis breast carcinoma Breast Neoplasms - metabolism Breast Neoplasms - mortality Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - mortality Carcinoma, Lobular - metabolism Carcinoma, Lobular - mortality Chi-Square Distribution Female Humans Immunohistochemistry - methods In Situ Hybridization - methods Ki-67 Antigen - analysis lymph node metastasis Lymphatic Metastasis Middle Aged prognosis Proto-Oncogene Proteins c-bcl-2 - analysis Receptor, ErbB-2 - analysis Ribonuclease, Pancreatic RNA, Messenger - metabolism Survival Rate tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA Tissue Inhibitor of Metalloproteinase-1 - genetics
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