The selective group mGlu2/3 receptor agonist LY379268 suppresses REM sleep and fast EEG in the rat

Studies of ionotropic receptors indicate that glutamate (Glu) neurotransmission plays a role in sleep. Here, we show for the first time that metabotropic 2/3 Glu (mGlu2/3) receptors play an active or permissive role in the control of REM sleep. The potent, selective, and systemically active mGlu2/3...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-09, Vol.73 (2), p.467-474
Hauptverfasser:	Feinberg, I, Campbell, I.G, Schoepp, D.D, Anderson, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - pharmacology Animals Arousal - drug effects Behavior, Animal - drug effects Bridged Bicyclo Compounds, Heterocyclic - pharmacology Depression, Chemical EEG Electroencephalography - drug effects Electromyography - drug effects Excitatory Amino Acid Agonists - pharmacology FFT Fourier Analysis Glutamate Male Metabotropic Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate - agonists REM Sleep Sleep - drug effects Sleep, REM - drug effects Wakefulness - drug effects
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