Synthesis and Target Identification of Hymenialdisine Analogs

Hymenialdisine (HMD) is a sponge-derived natural product kinase inhibitor with nanomolar activity against CDKs, Mek1, GSK3β, and CK1 and micromolar activity against Chk1. In order to explore the broader application of the pyrrolo[2,3-c]azepine skeleton of HMD as a general kinase inhibitory scaffold,...

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Veröffentlicht in:	Chemistry & biology 2004-02, Vol.11 (2), p.247-259
Hauptverfasser:	Wan, Yongqin, Hur, Wooyoung, Cho, Charles Y., Liu, Yi, Adrian, Francisco J., Lozach, Olivier, Bach, Stéphane, Mayer, Thomas, Fabbro, Doriano, Meijer, Laurent, Gray, Nathanael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Azepines - chemical synthesis Azepines - chemistry Azepines - pharmacology Chromatography, Affinity Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Molecular Sequence Data Phosphotransferases - antagonists & inhibitors Phosphotransferases - metabolism Pyrroles - chemical synthesis Pyrroles - chemistry Pyrroles - pharmacology Structure-Activity Relationship
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