Invasive testing for the karyotyping of mid-trimester intrauterine fetal death (IUFD): a pilot study
Introduction Aneuploidy remains a common cause of fetal loss after the first trimester. Conventional karyotyping from fetal solid tissues post‐delivery unfortunately has a poor success rate particularly where the fetus is macerated. To overcome this we obtained amniocentesis and/or chorionic villus...
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| Veröffentlicht in: | Prenatal diagnosis 2002-06, Vol.22 (6), p.453-455 |
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| creator | Howarth, E. S. Konje, J. C. Healey, K. A. Duckett, D. P. Scudamore, I. W. Taylor, D. J. |
| description | Introduction
Aneuploidy remains a common cause of fetal loss after the first trimester. Conventional karyotyping from fetal solid tissues post‐delivery unfortunately has a poor success rate particularly where the fetus is macerated. To overcome this we obtained amniocentesis and/or chorionic villus samples from mid‐trimester intrauterine fetal deaths (IUFDs) prior to medical termination of pregnancy.
Subjects
Ten women with diagnosed IUFD between 12 and 24 weeks' gestation underwent amniocentesis and/or CVS performed after counselling.
Results
Successful karyotypes were obtained in all pregnancies. Five of the ten pregnancies were complicated by aneuploidy (two with trisomy 21, two with trisomy 18, and one with trisomy 13).
Conclusion
The high rate of aneuploidy (50%) in this small cohort emphasises the need for karyotyping. A successful karyotype in all ten pregnancies demonstrates the value of offering these procedures before a termination of pregnancy. We would recommend the adoption of this approach in the management of IUFD occurring after the first trimester. Copyright © 2002 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/pd.339 |
| format | Article |
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Aneuploidy remains a common cause of fetal loss after the first trimester. Conventional karyotyping from fetal solid tissues post‐delivery unfortunately has a poor success rate particularly where the fetus is macerated. To overcome this we obtained amniocentesis and/or chorionic villus samples from mid‐trimester intrauterine fetal deaths (IUFDs) prior to medical termination of pregnancy.
Subjects
Ten women with diagnosed IUFD between 12 and 24 weeks' gestation underwent amniocentesis and/or CVS performed after counselling.
Results
Successful karyotypes were obtained in all pregnancies. Five of the ten pregnancies were complicated by aneuploidy (two with trisomy 21, two with trisomy 18, and one with trisomy 13).
Conclusion
The high rate of aneuploidy (50%) in this small cohort emphasises the need for karyotyping. A successful karyotype in all ten pregnancies demonstrates the value of offering these procedures before a termination of pregnancy. We would recommend the adoption of this approach in the management of IUFD occurring after the first trimester. Copyright © 2002 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.339</identifier><identifier>PMID: 12116301</identifier><identifier>CODEN: PRDIDM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adolescent ; Adult ; Amniocentesis ; Biological and medical sciences ; Chorionic Villi Sampling ; Chromosomes, Human, Pair 13 ; Chromosomes, Human, Pair 18 ; Diseases of mother, fetus and pregnancy ; Down Syndrome - genetics ; Female ; Fetal Death - genetics ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; intrauterine fetal death (IUFD) ; karyotyping ; Karyotyping - methods ; Management. Prenatal diagnosis ; Medical sciences ; mid-trimester ; Pilot Projects ; Pregnancy ; Pregnancy. Fetus. Placenta ; Trisomy</subject><ispartof>Prenatal diagnosis, 2002-06, Vol.22 (6), p.453-455</ispartof><rights>Copyright © 2002 John Wiley & Sons, Ltd.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3779-5ee9300a872e76034d7ebf24a42caa07d7cac6f53fb0c332ac5d9c445490cd8c3</citedby><cites>FETCH-LOGICAL-c3779-5ee9300a872e76034d7ebf24a42caa07d7cac6f53fb0c332ac5d9c445490cd8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.339$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.339$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13725315$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12116301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Howarth, E. S.</creatorcontrib><creatorcontrib>Konje, J. C.</creatorcontrib><creatorcontrib>Healey, K. A.</creatorcontrib><creatorcontrib>Duckett, D. P.</creatorcontrib><creatorcontrib>Scudamore, I. W.</creatorcontrib><creatorcontrib>Taylor, D. J.</creatorcontrib><title>Invasive testing for the karyotyping of mid-trimester intrauterine fetal death (IUFD): a pilot study</title><title>Prenatal diagnosis</title><addtitle>Prenat. Diagn</addtitle><description>Introduction
Aneuploidy remains a common cause of fetal loss after the first trimester. Conventional karyotyping from fetal solid tissues post‐delivery unfortunately has a poor success rate particularly where the fetus is macerated. To overcome this we obtained amniocentesis and/or chorionic villus samples from mid‐trimester intrauterine fetal deaths (IUFDs) prior to medical termination of pregnancy.
Subjects
Ten women with diagnosed IUFD between 12 and 24 weeks' gestation underwent amniocentesis and/or CVS performed after counselling.
Results
Successful karyotypes were obtained in all pregnancies. Five of the ten pregnancies were complicated by aneuploidy (two with trisomy 21, two with trisomy 18, and one with trisomy 13).
Conclusion
The high rate of aneuploidy (50%) in this small cohort emphasises the need for karyotyping. A successful karyotype in all ten pregnancies demonstrates the value of offering these procedures before a termination of pregnancy. We would recommend the adoption of this approach in the management of IUFD occurring after the first trimester. Copyright © 2002 John Wiley & Sons, Ltd.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Amniocentesis</subject><subject>Biological and medical sciences</subject><subject>Chorionic Villi Sampling</subject><subject>Chromosomes, Human, Pair 13</subject><subject>Chromosomes, Human, Pair 18</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Down Syndrome - genetics</subject><subject>Female</subject><subject>Fetal Death - genetics</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>intrauterine fetal death (IUFD)</subject><subject>karyotyping</subject><subject>Karyotyping - methods</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>mid-trimester</subject><subject>Pilot Projects</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Trisomy</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10F1PFDEUBuDGSGRF_QmmNxK5GOzHzHbqnWEFNgE_gsTL5mx7KpXZmaHtoPvvLdkNXHnR9KR52tPzEvKGs2POmPgwumMp9TMy40yrigkhn5MZ46WWbcP3ycuUfhfXCq1ekH0uOJ9LxmfELft7SOEeacaUQ_-L-iHSfIP0FuJmyJvx4WzwdB1clWNYF4WRhj5HmEoVeqQeM3TUIeQb-n55fbo4-kiBjqEbMk15cptXZM9Dl_D1bj8g16eff5ycVxdfz5Ynny4qK5XSVYOoJWPQKoFqzmTtFK68qKEWFoAppyzYuW-kXzErpQDbOG3ruqk1s6618oAcbt8d43A3lZ-adUgWuw56HKZkFG-1bMt6hDYOKUX0ZiyjlYENZ-YhTzM6U_Is8O3uxWm1RvfEdgEW8G4HIFnofITehvTkpBKN5E1xR1v3J3S4-U87822xbVptbShZ_320EG_NXEnVmJ9fzszi6vL8u75qy71_VwWZjg</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>Howarth, E. S.</creator><creator>Konje, J. C.</creator><creator>Healey, K. A.</creator><creator>Duckett, D. P.</creator><creator>Scudamore, I. W.</creator><creator>Taylor, D. J.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200206</creationdate><title>Invasive testing for the karyotyping of mid-trimester intrauterine fetal death (IUFD): a pilot study</title><author>Howarth, E. S. ; Konje, J. C. ; Healey, K. A. ; Duckett, D. P. ; Scudamore, I. W. ; Taylor, D. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3779-5ee9300a872e76034d7ebf24a42caa07d7cac6f53fb0c332ac5d9c445490cd8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Amniocentesis</topic><topic>Biological and medical sciences</topic><topic>Chorionic Villi Sampling</topic><topic>Chromosomes, Human, Pair 13</topic><topic>Chromosomes, Human, Pair 18</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Down Syndrome - genetics</topic><topic>Female</topic><topic>Fetal Death - genetics</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>intrauterine fetal death (IUFD)</topic><topic>karyotyping</topic><topic>Karyotyping - methods</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>mid-trimester</topic><topic>Pilot Projects</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Trisomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Howarth, E. S.</creatorcontrib><creatorcontrib>Konje, J. C.</creatorcontrib><creatorcontrib>Healey, K. A.</creatorcontrib><creatorcontrib>Duckett, D. P.</creatorcontrib><creatorcontrib>Scudamore, I. W.</creatorcontrib><creatorcontrib>Taylor, D. J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Howarth, E. S.</au><au>Konje, J. C.</au><au>Healey, K. A.</au><au>Duckett, D. P.</au><au>Scudamore, I. W.</au><au>Taylor, D. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Invasive testing for the karyotyping of mid-trimester intrauterine fetal death (IUFD): a pilot study</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat. Diagn</addtitle><date>2002-06</date><risdate>2002</risdate><volume>22</volume><issue>6</issue><spage>453</spage><epage>455</epage><pages>453-455</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><coden>PRDIDM</coden><abstract>Introduction
Aneuploidy remains a common cause of fetal loss after the first trimester. Conventional karyotyping from fetal solid tissues post‐delivery unfortunately has a poor success rate particularly where the fetus is macerated. To overcome this we obtained amniocentesis and/or chorionic villus samples from mid‐trimester intrauterine fetal deaths (IUFDs) prior to medical termination of pregnancy.
Subjects
Ten women with diagnosed IUFD between 12 and 24 weeks' gestation underwent amniocentesis and/or CVS performed after counselling.
Results
Successful karyotypes were obtained in all pregnancies. Five of the ten pregnancies were complicated by aneuploidy (two with trisomy 21, two with trisomy 18, and one with trisomy 13).
Conclusion
The high rate of aneuploidy (50%) in this small cohort emphasises the need for karyotyping. A successful karyotype in all ten pregnancies demonstrates the value of offering these procedures before a termination of pregnancy. We would recommend the adoption of this approach in the management of IUFD occurring after the first trimester. Copyright © 2002 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12116301</pmid><doi>10.1002/pd.339</doi><tpages>3</tpages></addata></record> |
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| ispartof | Prenatal diagnosis, 2002-06, Vol.22 (6), p.453-455 |
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| subjects | Adolescent Adult Amniocentesis Biological and medical sciences Chorionic Villi Sampling Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 18 Diseases of mother, fetus and pregnancy Down Syndrome - genetics Female Fetal Death - genetics Gestational Age Gynecology. Andrology. Obstetrics Humans intrauterine fetal death (IUFD) karyotyping Karyotyping - methods Management. Prenatal diagnosis Medical sciences mid-trimester Pilot Projects Pregnancy Pregnancy. Fetus. Placenta Trisomy |
| title | Invasive testing for the karyotyping of mid-trimester intrauterine fetal death (IUFD): a pilot study |
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