A reversible functional defect of CD8+ T lymphocytes involving loss of tetramer labeling

We have observed that human CTL clones lose their specific cytolytic activity and cytokine production under certain stimulation conditions, while retaining an antigen‐dependent growth pattern.These inactive CTL simultaneously lose their labeling by an HLA‐peptide tetramer, even though the amount of...

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Veröffentlicht in:	European journal of immunology 2002-06, Vol.32 (6), p.1688-1697
Hauptverfasser:	Demotte, Nathalie, Colau, Didier, Ottaviani, Sabrina, Godelaine, Danièle, Pel, Aline Van, Boon, Thierry, Bruggen, Pierre van der
Format:	Artikel
Sprache:	eng
Schlagworte:	Anergy Antigens, Neoplasm CD3 CD8 Antigens - physiology CD8-Positive T-Lymphocytes - physiology Cell Line CTL Cytokines - biosynthesis Cytotoxicity, Immunologic Epstein‐Barr virus Herpesvirus 4, Human HLA-A3 Antigen - chemistry HLA-A3 Antigen - metabolism Humans Melanoma-Specific Antigens Neoplasm Proteins - physiology Receptor-CD3 Complex, Antigen, T-Cell - analysis Receptors, Antigen, T-Cell - analysis Staining and Labeling Tetramer
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