Pharmacokinetics of marbofloxacin in mature horses after single intravenous and intramuscular administration

Summary The pharmacokinetic behaviour of marbofloxacin, a new fluoroquinolone antimicrobial agent developed exclusively for veterinary use, was studied in mature horses (n = 5) after single‐dose i.v. and i.m. administrations of 2 mg/kg bwt. Drug concentrations in plasma were determined by high perfo...

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Veröffentlicht in:	Equine veterinary journal 2002-07, Vol.34 (4), p.360-365
Hauptverfasser:	CARRETERO, M., RODRÍGUEZ, C., ANDRÉS, M. I. SAN, FORÉS, P., LUCAS, J.J. de, NIETO, J., WAXMAN, S., ANDRÉS, M. D. SAN, GONZÁLEZ, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - blood Anti-Infective Agents - pharmacokinetics Bacteria - drug effects Bacteria - growth & development Bacterial Infections - drug therapy Bacterial Infections - veterinary Biological Availability Chromatography, High Pressure Liquid - veterinary Colony Count, Microbial - veterinary creatine phosphokinase dosage strategies Dose-Response Relationship, Drug Female Fluoroquinolones horse Horse Diseases - drug therapy Horse Diseases - microbiology Horses - blood Horses - metabolism Injections, Intramuscular - veterinary Injections, Intravenous - veterinary intramuscular intravenous Male marbofloxacin Metabolic Clearance Rate pharmacokinetic Quinolones - administration & dosage Quinolones - blood Quinolones - pharmacokinetics Reference Values Tissue Distribution tissue irritation Treatment Outcome
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