Different levels of neuroprotection by two insulin-like growth factor-I splice variants
We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsi...
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| Veröffentlicht in: | Brain research 2004-05, Vol.1009 (1), p.213-218 |
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| creator | Aperghis, Michael Johnson, Ian P. Cannon, John Yang, Shi-Yu Goldspink, Geoffrey |
| description | We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion. This resulted in significant neuroprotection of 88% and 37%, respectively, of motoneurons compared to control plasmid and avulsion-only groups. MGF is markedly more effective than the liver-type, systemic IGF-I for motoneuron survival, suggesting a major role for the peripheral target in adult neuronal maintenance and survival. |
| doi_str_mv | 10.1016/j.brainres.2004.02.049 |
| format | Article |
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Psychology ; Gene Transfer, Horizontal - physiology ; IGF-I ; Injections, Intramuscular ; Insulin-Like Growth Factor I - chemistry ; Insulin-Like Growth Factor I - genetics ; Insulin-Like Growth Factor I - physiology ; Male ; MGF ; Molecular and cellular biology ; Motoneuron ; Motor Neurons - metabolism ; Myosin Heavy Chains - genetics ; Rabbits ; Rats ; Rats, Sprague-Dawley ; Responses to growth factors, tumor promotors, other factors ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Messenger - biosynthesis ; Transfection - methods</subject><ispartof>Brain research, 2004-05, Vol.1009 (1), p.213-218</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-38405e34c732a535dbe5d44451727546943243b160b3689ac4c76b1908bc47cc3</citedby><cites>FETCH-LOGICAL-c491t-38405e34c732a535dbe5d44451727546943243b160b3689ac4c76b1908bc47cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899304003488$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15718752$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15120599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aperghis, Michael</creatorcontrib><creatorcontrib>Johnson, Ian P.</creatorcontrib><creatorcontrib>Cannon, John</creatorcontrib><creatorcontrib>Yang, Shi-Yu</creatorcontrib><creatorcontrib>Goldspink, Geoffrey</creatorcontrib><title>Different levels of neuroprotection by two insulin-like growth factor-I splice variants</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion. This resulted in significant neuroprotection of 88% and 37%, respectively, of motoneurons compared to control plasmid and avulsion-only groups. MGF is markedly more effective than the liver-type, systemic IGF-I for motoneuron survival, suggesting a major role for the peripheral target in adult neuronal maintenance and survival.</description><subject>Adult</subject><subject>Alternative Splicing</subject><subject>Animals</subject><subject>Avulsion</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Cell Survival - genetics</subject><subject>Facial Muscles - cytology</subject><subject>Facial nerve</subject><subject>Facial Nerve Injuries - metabolism</subject><subject>Functional Laterality - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Transfer, Horizontal - physiology</subject><subject>IGF-I</subject><subject>Injections, Intramuscular</subject><subject>Insulin-Like Growth Factor I - chemistry</subject><subject>Insulin-Like Growth Factor I - genetics</subject><subject>Insulin-Like Growth Factor I - physiology</subject><subject>Male</subject><subject>MGF</subject><subject>Molecular and cellular biology</subject><subject>Motoneuron</subject><subject>Motor Neurons - metabolism</subject><subject>Myosin Heavy Chains - genetics</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Transfection - methods</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhL1S-wC3B34lvoBZopUpcQBwtx5mAF6-92M5W_fe42kX01tNopGdmXj2D0AUlPSVUvd_2U7Y-Zig9I0T0hPVE6GdoQ8eBdYoJ8hxtCCGqG7XmZ-hVKdvWcq7JS3RGJWVEar1BP678skCGWHGAA4SC04IjrDntc6rgqk8RT_e43iXsY1mDj13wvwH_zOmu_sKLdTXl7gaXffAO8MFmb2Mtr9GLxYYCb071HH3__Onb5XV3-_XLzeXH284JTWvHR0EkcOEGzqzkcp5AzkIISQc2SKG04EzwiSoycTVq6xqpJqrJODkxOMfP0bvj3hb3zwqlmp0vDkKwEdJazEBH3TbRJ0E6EtXMjg1UR9DlVEqGxeyz39l8bygxD-7N1vxzbx7cG8JMc98GL04X1mkH8_-xk-wGvD0Btjgblmyj8-UR18IOkjXuw5Fr74CDh2yK8xAdzD63j5g5-aey_AVKVqU_</recordid><startdate>20040529</startdate><enddate>20040529</enddate><creator>Aperghis, Michael</creator><creator>Johnson, Ian P.</creator><creator>Cannon, John</creator><creator>Yang, Shi-Yu</creator><creator>Goldspink, Geoffrey</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040529</creationdate><title>Different levels of neuroprotection by two insulin-like growth factor-I splice variants</title><author>Aperghis, Michael ; Johnson, Ian P. ; Cannon, John ; Yang, Shi-Yu ; Goldspink, Geoffrey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-38405e34c732a535dbe5d44451727546943243b160b3689ac4c76b1908bc47cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Alternative Splicing</topic><topic>Animals</topic><topic>Avulsion</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Cell Survival - genetics</topic><topic>Facial Muscles - cytology</topic><topic>Facial nerve</topic><topic>Facial Nerve Injuries - metabolism</topic><topic>Functional Laterality - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Transfer, Horizontal - physiology</topic><topic>IGF-I</topic><topic>Injections, Intramuscular</topic><topic>Insulin-Like Growth Factor I - chemistry</topic><topic>Insulin-Like Growth Factor I - genetics</topic><topic>Insulin-Like Growth Factor I - physiology</topic><topic>Male</topic><topic>MGF</topic><topic>Molecular and cellular biology</topic><topic>Motoneuron</topic><topic>Motor Neurons - metabolism</topic><topic>Myosin Heavy Chains - genetics</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Transfection - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aperghis, Michael</creatorcontrib><creatorcontrib>Johnson, Ian P.</creatorcontrib><creatorcontrib>Cannon, John</creatorcontrib><creatorcontrib>Yang, Shi-Yu</creatorcontrib><creatorcontrib>Goldspink, Geoffrey</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aperghis, Michael</au><au>Johnson, Ian P.</au><au>Cannon, John</au><au>Yang, Shi-Yu</au><au>Goldspink, Geoffrey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different levels of neuroprotection by two insulin-like growth factor-I splice variants</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2004-05-29</date><risdate>2004</risdate><volume>1009</volume><issue>1</issue><spage>213</spage><epage>218</epage><pages>213-218</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Alternative Splicing Animals Avulsion Biological and medical sciences Cell physiology Cell Survival - genetics Facial Muscles - cytology Facial nerve Facial Nerve Injuries - metabolism Functional Laterality - physiology Fundamental and applied biological sciences. Psychology Gene Transfer, Horizontal - physiology IGF-I Injections, Intramuscular Insulin-Like Growth Factor I - chemistry Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - physiology Male MGF Molecular and cellular biology Motoneuron Motor Neurons - metabolism Myosin Heavy Chains - genetics Rabbits Rats Rats, Sprague-Dawley Responses to growth factors, tumor promotors, other factors Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis Transfection - methods |
| title | Different levels of neuroprotection by two insulin-like growth factor-I splice variants |
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