Developmental effects of von Hippel-Lindau gene deficiency

The histogenetic origin and the basis of the distribution of central nervous system (CNS) hemangioblastomas in the von Hippel–Lindau (VHL) tumor suppressor gene syndrome, VHL disease, are unknown. To better understand hemangioblastoma histogenesis, we analyzed postmortem CNS tissues from four patien...

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Veröffentlicht in:	Annals of neurology 2004-05, Vol.55 (5), p.721-728
Hauptverfasser:	Vortmeyer, Alexander O., Yuan, Quingyang, Lee, Youn-Soo, Zhuang, Zhengping, Oldfield, Edward H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Central Nervous System - pathology Central Nervous System Neoplasms - genetics Central Nervous System Neoplasms - pathology Hemangioblastoma - genetics Hemangioblastoma - pathology Humans Male Medical sciences Mesoderm - pathology Middle Aged Neurology Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - genetics Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics von Hippel-Lindau Disease - genetics von Hippel-Lindau Disease - pathology Von Hippel-Lindau Tumor Suppressor Protein
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