Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide

Early stage leukocyte entrapment in the retinal microcirculation (retinal leukostasis) is considered to be one of the important pathogenetic events in diabetic retinopathy. Gliclazide, a sulphonylurea, was reported to reduce leukocyte adhesion to endothelial cells in hyperglycaemia in vitro, thus su...

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Veröffentlicht in:	Diabetologia 2002-05, Vol.45 (5), p.735-739
Hauptverfasser:	KINOSHITA, N, KAKEHASHI, A, INODA, S, ITOU, Y, KUROKI, M, YASU, T, KAWAKAMI, M, KANAZAWA, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Adhesion Diabetes Mellitus, Experimental - drug therapy Diabetic Retinopathy - prevention & control General and cellular metabolism. Vitamins Gliclazide - therapeutic use Hypoglycemic Agents - therapeutic use Leukocytes - drug effects Leukocytes - physiology Leukostasis - prevention & control Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred BN
Online-Zugang:	Volltext
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