Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration
The literature concerning Schwann cells (SCs) and macrophages in myelin phagocytosis during Wallerian degeneration is reviewed. SCs carry out the first step in the removal of myelin by segmenting myelin and then incorporating the degraded myelin. The recruited macrophages then join in the myelin‐pha...
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| Veröffentlicht in: | Microscopy research and technique 2002-06, Vol.57 (6), p.541-547 |
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| creator | Hirata, Kazuho Kawabuchi, Masaru |
| description | The literature concerning Schwann cells (SCs) and macrophages in myelin phagocytosis during Wallerian degeneration is reviewed. SCs carry out the first step in the removal of myelin by segmenting myelin and then incorporating the degraded myelin. The recruited macrophages then join in the myelin‐phagocytosis event, appearing to make full use of their original phagocyte abilities until the end of myelin clearance. The molecular mechanisms of the two cells underlying myelin phagocytosis are thought to be different; myelin phagocytosis by SCs being lectin‐mediated, i.e., opsonin‐independent, whereas that of macrophages is mainly opsonin‐dependent. It is important to note that SCs and macrophages cooperatively accomplish myelin phagocytosis. Microsc. Res. Tech. 57:541–547, 2002. © 2002 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jemt.10108 |
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Tech. 57:541–547, 2002. © 2002 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>confocal laser scanning microscopy</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Macrophages - immunology</subject><subject>Microscopy, Confocal</subject><subject>myelin sheath</subject><subject>Myelin Sheath - immunology</subject><subject>Myelin Sheath - physiology</subject><subject>Phagocytosis</subject><subject>Rats</subject><subject>Schwann cells</subject><subject>Schwann Cells - immunology</subject><subject>Sciatic Nerve - ultrastructure</subject><subject>Wallerian Degeneration - physiopathology</subject><issn>1059-910X</issn><issn>1097-0029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0E4lG48ANQThyQAt48nPiIEE9ROLRSuVkbd1MMiVPsVJB_T0rL48RpR6NvRqth7BD4KXAenb1Q3fYKeL7BdoHLLOxdubnUqQwl8Kcdtuf9C-cAKSTbbAcigCiJs102GnZUGRvMn3HW6K5tvPFB0QU1atcsTfIB2mlgG_vXmi6csbNgglVFzqANpjQjSw5b09h9tlVi5elgfQdsfHU5vrgJ7x-vby_O70OdiDQPSwISGmWalqiLJALSGGeoo4KLkmRW6kKgKJEiFFpQAQXPNegI01ximcQDdryqnbvmbUG-VbXxmqoKLTULrzLIJc9z6MGTFdj_772jUs2dqdF1CrhaLqiWC6qvBXv4aN26KGqa_qLryXoAVsC7qaj7p0rdXQ7H36XhKmN8Sx8_GXSvSmRxlqrJw7WaDEdX8kaMlYg_Afhzjdo</recordid><startdate>20020615</startdate><enddate>20020615</enddate><creator>Hirata, Kazuho</creator><creator>Kawabuchi, Masaru</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020615</creationdate><title>Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration</title><author>Hirata, Kazuho ; Kawabuchi, Masaru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4658-fe1e6ca955facb421eca37ac2b06fe97fcb6a6fae2a6c6eb1b08c1c2a589af43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>confocal laser scanning microscopy</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Macrophages - immunology</topic><topic>Microscopy, Confocal</topic><topic>myelin sheath</topic><topic>Myelin Sheath - immunology</topic><topic>Myelin Sheath - physiology</topic><topic>Phagocytosis</topic><topic>Rats</topic><topic>Schwann cells</topic><topic>Schwann Cells - immunology</topic><topic>Sciatic Nerve - ultrastructure</topic><topic>Wallerian Degeneration - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirata, Kazuho</creatorcontrib><creatorcontrib>Kawabuchi, Masaru</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microscopy research and technique</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirata, Kazuho</au><au>Kawabuchi, Masaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration</atitle><jtitle>Microscopy research and technique</jtitle><addtitle>Microsc. 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| subjects | Animals confocal laser scanning microscopy Humans Immunohistochemistry Macrophages - immunology Microscopy, Confocal myelin sheath Myelin Sheath - immunology Myelin Sheath - physiology Phagocytosis Rats Schwann cells Schwann Cells - immunology Sciatic Nerve - ultrastructure Wallerian Degeneration - physiopathology |
| title | Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration |
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