Ryanodine receptors in human pancreatic β cells: localization and effects on insulin secretion

ABSTRACT It is clear that pancreatic β‐cell dysfunction, including basal hyperinsulinemia and reduced insulin release in response to glucose, is a key determinant of disease progression in type 2 diabetes, but the underlying molecular defects are not known. In diabetes, the expression and function o...

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Veröffentlicht in:	The FASEB journal 2004-05, Vol.18 (7), p.878-880
Hauptverfasser:	Johnson, James D., Kuang, Shihuan, Misler, Stanley, Polonsky, Kenneth S.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase - physiology ADP-ribosyl Cyclase 1 Animals Antigens, CD - physiology basal hyperinsulinemia Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology calcium stores CD38 Cells, Cultured - drug effects Cells, Cultured - metabolism Dantrolene - pharmacology diabetes Dose-Response Relationship, Drug Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Endosomes - metabolism exocytosis Exocytosis - drug effects Glucose - pharmacology Humans Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism Macrocyclic Compounds Membrane Glycoproteins Mice Oxazoles - pharmacology Patch-Clamp Techniques Potassium Chloride - pharmacology Ryanodine - pharmacology Ryanodine Receptor Calcium Release Channel - drug effects Ryanodine Receptor Calcium Release Channel - physiology Thapsigargin - pharmacology
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