Inhibition of vaccinia virus replication by adenosine in BSC-40 cells: involvement of A(2) receptor-mediated PKA activation

In the present study, we show that adenosine (Ado) affects vaccinia virus (VV) replication in BSC-40 cells. In order to identify its effects on VV replicative cycle we analyzed the synthesis of virus macromolecules in cells incubated with 0.5 mM Ado. A 50% reduction in the steady-state level of viru...

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Veröffentlicht in:	Archives of virology 2002-07, Vol.147 (7), p.1407-1423
Hauptverfasser:	Leão-Ferreira, L R, Paes-De-Carvalho, R, De Mello, F G, Moussatché, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - antagonists & inhibitors Adenosine - pharmacology Animals Antiviral Agents - pharmacology Carrier Proteins - pharmacology Cell Line Coculture Techniques Cyclic AMP - analysis Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Dose-Response Relationship, Drug Enzyme Activation - drug effects Epithelial Cells - metabolism Epithelial Cells - virology Intracellular Signaling Peptides and Proteins Phosphodiesterase Inhibitors - pharmacology Protein Synthesis Inhibitors - pharmacology Purinergic P1 Receptor Antagonists Receptors, Purinergic P1 - metabolism Signal Transduction Theobromine - analogs & derivatives Theobromine - pharmacology Theophylline - pharmacology Vaccinia virus - drug effects Vaccinia virus - physiology Virus Replication - drug effects
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