Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4)
Cyclic adenosine monophosphate (cAMP) response element-binding (CREB) proteins are a family of mammalian transcription activators. We identified a novel human CREB gene ( CREB4 ) that was 1592 bp long and encoded a protein of 395 amino acid residues. The protein shared high homology to mouse CREB3 (...
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| Veröffentlicht in: | Journal of human genetics 2002-01, Vol.47 (7), p.373-376 |
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| container_title | Journal of human genetics |
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| creator | Cao, G. Ni, X. Jiang, M. Ma, Y. Cheng, H. Guo, L. Ji, C. Gu, S. Xie, Y. Mao, Y. |
| description | Cyclic adenosine monophosphate (cAMP) response element-binding (CREB) proteins are a family of mammalian transcription activators. We identified a novel human
CREB
gene (
CREB4
) that was 1592 bp long and encoded a protein of 395 amino acid residues. The protein shared high homology to mouse CREB3 (identity 62%, similarity 72%). The expression pattern of the human
CREB4
gene showed transcripts in prostate, brain, pancreas, skeletal muscle, small intestine, testis, leukocyte, and thymus, whereas in heart, lung, liver, kidney, placenta, spleen, ovary, and colon, specific bands of the transcript could not be detected. The
CREB4
gene consisted of ten exons and nine introns and was mapped to chromosome 1q21.3 by means of a bioinformatics analysis. |
| doi_str_mv | 10.1007/s100380200053 |
| format | Article |
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CREB
gene (
CREB4
) that was 1592 bp long and encoded a protein of 395 amino acid residues. The protein shared high homology to mouse CREB3 (identity 62%, similarity 72%). The expression pattern of the human
CREB4
gene showed transcripts in prostate, brain, pancreas, skeletal muscle, small intestine, testis, leukocyte, and thymus, whereas in heart, lung, liver, kidney, placenta, spleen, ovary, and colon, specific bands of the transcript could not be detected. The
CREB4
gene consisted of ten exons and nine introns and was mapped to chromosome 1q21.3 by means of a bioinformatics analysis.</description><identifier>ISSN: 1434-5161</identifier><identifier>EISSN: 1435-232X</identifier><identifier>DOI: 10.1007/s100380200053</identifier><identifier>PMID: 12111373</identifier><language>eng</language><publisher>Tokyo: Springer-Verlag</publisher><subject>Amino Acid Sequence ; Amino acids ; AMP ; Animals ; Basic-Leucine Zipper Transcription Factors ; Bioinformatics ; Biomedical and Life Sciences ; Biomedicine ; Chromosome 1 ; Chromosome Mapping ; Chromosomes, Human, Pair 1 ; Cloning ; Colon ; Cyclic AMP Response Element-Binding Protein ; Exons ; Gene Expression ; Gene Function ; Gene Therapy ; Homology ; Human Genetics ; Humans ; Hydrogen-Ion Concentration ; Introns ; Kidneys ; Mice ; Molecular Medicine ; Molecular Sequence Data ; Nuclear Proteins ; Organ Specificity ; Pancreas ; Placenta ; Prostate ; Sequence Alignment ; Short Communication ; Skeletal muscle ; Small intestine ; Spleen ; Transcription factors ; Transcription Factors - genetics</subject><ispartof>Journal of human genetics, 2002-01, Vol.47 (7), p.373-376</ispartof><rights>The Japanese Society of Human Genetics and Springer-Verlag Tokyo 2002</rights><rights>The Japanese Society of Human Genetics and Springer-Verlag Tokyo 2002.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-349d0ed1a06f1657fee3e1fd61b8ab0a25c0e4fd752fb763c50d578e3f017223</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s100380200053$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s100380200053$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12111373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, G.</creatorcontrib><creatorcontrib>Ni, X.</creatorcontrib><creatorcontrib>Jiang, M.</creatorcontrib><creatorcontrib>Ma, Y.</creatorcontrib><creatorcontrib>Cheng, H.</creatorcontrib><creatorcontrib>Guo, L.</creatorcontrib><creatorcontrib>Ji, C.</creatorcontrib><creatorcontrib>Gu, S.</creatorcontrib><creatorcontrib>Xie, Y.</creatorcontrib><creatorcontrib>Mao, Y.</creatorcontrib><title>Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4)</title><title>Journal of human genetics</title><addtitle>J Hum Genet</addtitle><addtitle>J Hum Genet</addtitle><description>Cyclic adenosine monophosphate (cAMP) response element-binding (CREB) proteins are a family of mammalian transcription activators. We identified a novel human
CREB
gene (
CREB4
) that was 1592 bp long and encoded a protein of 395 amino acid residues. The protein shared high homology to mouse CREB3 (identity 62%, similarity 72%). The expression pattern of the human
CREB4
gene showed transcripts in prostate, brain, pancreas, skeletal muscle, small intestine, testis, leukocyte, and thymus, whereas in heart, lung, liver, kidney, placenta, spleen, ovary, and colon, specific bands of the transcript could not be detected. The
CREB4
gene consisted of ten exons and nine introns and was mapped to chromosome 1q21.3 by means of a bioinformatics analysis.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>AMP</subject><subject>Animals</subject><subject>Basic-Leucine Zipper Transcription Factors</subject><subject>Bioinformatics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Chromosome 1</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 1</subject><subject>Cloning</subject><subject>Colon</subject><subject>Cyclic AMP Response Element-Binding Protein</subject><subject>Exons</subject><subject>Gene Expression</subject><subject>Gene Function</subject><subject>Gene Therapy</subject><subject>Homology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Introns</subject><subject>Kidneys</subject><subject>Mice</subject><subject>Molecular Medicine</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins</subject><subject>Organ Specificity</subject><subject>Pancreas</subject><subject>Placenta</subject><subject>Prostate</subject><subject>Sequence Alignment</subject><subject>Short Communication</subject><subject>Skeletal muscle</subject><subject>Small intestine</subject><subject>Spleen</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><issn>1434-5161</issn><issn>1435-232X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpt0U1LxDAQBuAgiuvX0asEBNFDNZM0TT3q4hcoiuzBW0nTyW6lTdakFfTXW92FRfGSGZiHNyFDyD6wU2BMncXhFDnjjDEp1sgWpEImXPCX9Z8-TSRkMCLbMb4ORHDFN8kIOAAIJbZI_eAbNH2jAzWNd7WbUu0qamY6aNNhqD91V3tHvaWaOv-ODZ31rXbUXDw80YBx7l1Eig226LqkrF31nXE8fr66PKFTdLjo05NdsmF1E3FvWXfI5PpqMr5N7h9v7sYX94mRwLtEpOcVwwo0yyxkUllEgWCrDMpcl0xzaRimtlKS21JlwkhWSZWjsAwU52KHHC1i58G_9Ri7oq2jwabRDn0fCwV5nmepGuDhH_jq--CGpxU85TLjjKcwqGShTPAxBrTFPNStDh8FsOJ7AcWvBQz-YJnaly1WK7388QGcLkAcRm6KYXXt_4lfkPaMVA</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Cao, G.</creator><creator>Ni, X.</creator><creator>Jiang, M.</creator><creator>Ma, Y.</creator><creator>Cheng, H.</creator><creator>Guo, L.</creator><creator>Ji, C.</creator><creator>Gu, S.</creator><creator>Xie, Y.</creator><creator>Mao, Y.</creator><general>Springer-Verlag</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4)</title><author>Cao, G. ; Ni, X. ; Jiang, M. ; Ma, Y. ; Cheng, H. ; Guo, L. ; Ji, C. ; Gu, S. ; Xie, Y. ; Mao, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-349d0ed1a06f1657fee3e1fd61b8ab0a25c0e4fd752fb763c50d578e3f017223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>AMP</topic><topic>Animals</topic><topic>Basic-Leucine Zipper Transcription Factors</topic><topic>Bioinformatics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Chromosome 1</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 1</topic><topic>Cloning</topic><topic>Colon</topic><topic>Cyclic AMP Response Element-Binding Protein</topic><topic>Exons</topic><topic>Gene Expression</topic><topic>Gene Function</topic><topic>Gene Therapy</topic><topic>Homology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Introns</topic><topic>Kidneys</topic><topic>Mice</topic><topic>Molecular Medicine</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins</topic><topic>Organ Specificity</topic><topic>Pancreas</topic><topic>Placenta</topic><topic>Prostate</topic><topic>Sequence Alignment</topic><topic>Short Communication</topic><topic>Skeletal muscle</topic><topic>Small intestine</topic><topic>Spleen</topic><topic>Transcription factors</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, G.</creatorcontrib><creatorcontrib>Ni, X.</creatorcontrib><creatorcontrib>Jiang, M.</creatorcontrib><creatorcontrib>Ma, Y.</creatorcontrib><creatorcontrib>Cheng, H.</creatorcontrib><creatorcontrib>Guo, L.</creatorcontrib><creatorcontrib>Ji, C.</creatorcontrib><creatorcontrib>Gu, S.</creatorcontrib><creatorcontrib>Xie, Y.</creatorcontrib><creatorcontrib>Mao, Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, G.</au><au>Ni, X.</au><au>Jiang, M.</au><au>Ma, Y.</au><au>Cheng, H.</au><au>Guo, L.</au><au>Ji, C.</au><au>Gu, S.</au><au>Xie, Y.</au><au>Mao, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4)</atitle><jtitle>Journal of human genetics</jtitle><stitle>J Hum Genet</stitle><addtitle>J Hum Genet</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>47</volume><issue>7</issue><spage>373</spage><epage>376</epage><pages>373-376</pages><issn>1434-5161</issn><eissn>1435-232X</eissn><abstract>Cyclic adenosine monophosphate (cAMP) response element-binding (CREB) proteins are a family of mammalian transcription activators. We identified a novel human
CREB
gene (
CREB4
) that was 1592 bp long and encoded a protein of 395 amino acid residues. The protein shared high homology to mouse CREB3 (identity 62%, similarity 72%). The expression pattern of the human
CREB4
gene showed transcripts in prostate, brain, pancreas, skeletal muscle, small intestine, testis, leukocyte, and thymus, whereas in heart, lung, liver, kidney, placenta, spleen, ovary, and colon, specific bands of the transcript could not be detected. The
CREB4
gene consisted of ten exons and nine introns and was mapped to chromosome 1q21.3 by means of a bioinformatics analysis.</abstract><cop>Tokyo</cop><pub>Springer-Verlag</pub><pmid>12111373</pmid><doi>10.1007/s100380200053</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of human genetics, 2002-01, Vol.47 (7), p.373-376 |
| issn | 1434-5161 1435-232X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Amino Acid Sequence Amino acids AMP Animals Basic-Leucine Zipper Transcription Factors Bioinformatics Biomedical and Life Sciences Biomedicine Chromosome 1 Chromosome Mapping Chromosomes, Human, Pair 1 Cloning Colon Cyclic AMP Response Element-Binding Protein Exons Gene Expression Gene Function Gene Therapy Homology Human Genetics Humans Hydrogen-Ion Concentration Introns Kidneys Mice Molecular Medicine Molecular Sequence Data Nuclear Proteins Organ Specificity Pancreas Placenta Prostate Sequence Alignment Short Communication Skeletal muscle Small intestine Spleen Transcription factors Transcription Factors - genetics |
| title | Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4) |
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