IGF-I and microglia/macrophage proliferation in the ischemic mouse brain

We have used a model of hypoxic‐ischemic brain injury in adult male C57BL/6 mice to study insulin‐like growth factor‐I (IGF‐I) and IGF‐binding protein (IGFBP) expression in response to cerebral hypoxia‐ischemia (H/I) in the adult mouse. A period of 20 min of H/I that resulted in histopathology in co...

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Veröffentlicht in:	Glia 2002-07, Vol.39 (1), p.85-97
Hauptverfasser:	O'Donnell, Steven L., Frederick, Terra J., Krady, J. Kyle, Vannucci, Susan J., Wood, Teresa L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - metabolism Biological and medical sciences Brain Ischemia - metabolism Brain Ischemia - pathology Cell Division Cells, Cultured CNS insult DNA Replication growth factors hypoxia-ischemia Insulin-Like Growth Factor Binding Protein 2 - biosynthesis Insulin-Like Growth Factor Binding Protein 2 - genetics Insulin-Like Growth Factor I - biosynthesis Insulin-Like Growth Factor I - genetics Macrophage Activation macrophages Macrophages - metabolism Macrophages - pathology Male Medical sciences Mice Mice, Inbred C57BL microglia Microglia - metabolism Microglia - pathology Neurology RNA, Messenger - biosynthesis stroke trophic factors Vascular diseases and vascular malformations of the nervous system
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