Identification and quantification of major maillard cross-links in human serum albumin and lens protein. Evidence for glucosepane as the dominant compound

Glycation reactions leading to protein modifications (advanced glycation end products) contribute to various pathologies associated with the general aging process and long term complications of diabetes. However, only few relevant compounds have so far been detected in vivo. We now report on the fir...

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Veröffentlicht in:	The Journal of biological chemistry 2002-07, Vol.277 (28), p.24907-24915
Hauptverfasser:	Biemel, Klaus M, Friedl, D Alexander, Lederer, Markus O
Format:	Artikel
Sprache:	eng
Schlagworte:	Azepines - chemistry Chromatography, Liquid Crystallins - chemistry Glycation End Products, Advanced Humans Kinetics Lens, Crystalline - chemistry Lysine - analogs & derivatives Lysine - chemistry Maillard Reaction Nuclear Magnetic Resonance, Biomolecular Serum Albumin - chemistry Spectrometry, Mass, Electrospray Ionization
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