Glucan stimulates human dermal fibroblast collagen biosynthesis through a nuclear factor-1 dependent mechanism

Glucan, an immunomodulator, has been reported to increase collagen deposition and tensile strength in experimental models of wound repair. Previous data suggest that glucan modulates wound healing via an indirect mechanism in which macrophages are stimulated to release growth factors and cytokines....

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Veröffentlicht in:	Wound repair and regeneration 2002-05, Vol.10 (3), p.161-168
Hauptverfasser:	Wei, Duo, Zhang, Leiying, Williams, David L., Browder, I. William
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology beta-Glucans CCAAT-Enhancer-Binding Proteins - metabolism Collagen - biosynthesis DNA-Binding Proteins Down-Regulation Electrophoretic Mobility Shift Assay Glucans - pharmacology Humans NFI Transcription Factors Nuclear Proteins Reverse Transcriptase Polymerase Chain Reaction Theobromine - analogs & derivatives Theobromine - pharmacology Transcription Factors - metabolism Transcription, Genetic - drug effects Wound Healing - physiology Y-Box-Binding Protein 1
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