Extracellular proteolysis in brain injury and inflammation: Role for plasminogen activators and matrix metalloproteinases

The role of intracellular proteases (e.g., calpains and caspases) in the pathophysiology of neuronal cell death has been extensively investigated. More recently, accumulating data have suggested that extracellular proteolysis also plays a critical role. The two major systems that modify the extracel...

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Veröffentlicht in:	Journal of neuroscience research 2002-07, Vol.69 (1), p.1-9
Hauptverfasser:	Lo, Eng H., Wang, Xiaoying, Cuzner, M. Louise
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood-brain barrier Brain Injuries - enzymology brain injury cell death demyelination ECM Encephalitis - enzymology Extracellular Matrix - enzymology Humans inflammation Matrix Metalloproteinases - physiology neuroprotection Plasminogen Activators - physiology
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