Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion

The inflammatory response initiated after spinal cord injury (SCI) is characterized by the accumulation of macrophages at the impact site. Monocyte chemoattractant protein‐1 (MCP‐1) is a strong candidate for mediating chemotaxis of monocytes to the injured nervous system. To help in defining the rol...

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Veröffentlicht in:	Journal of neuroscience research 2002-06, Vol.68 (6), p.691-702
Hauptverfasser:	Ma, Manhong, Wei, Tao, Boring, Landin, Charo, Israel F., Ransohoff, Richard M., Jakeman, Lyn B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals chemokine Chemokine CCL2 - metabolism chemokine receptor Contusions Immunohistochemistry inflammation macrophages Mice Mice, Inbred C57BL Mice, Knockout Monocyte Chemoattractant Proteins - metabolism Monocytes - metabolism Myelin Sheath - metabolism Phagocytosis Receptors, CCR2 Receptors, Chemokine - genetics RNA, Messenger - genetics Spinal Cord Injuries - metabolism spinal cord injury Time Factors
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