Anteromedial Temporal Lobe Damage Blocks Startle Modulation by Fear and Disgust
The acoustic startle reflex (ASR) is potentiated during negative emotion, but attenuated during positive emotional experience. The modulation of the ASR by fear depends critically on the amygdala. The authors investigated ASR modulation to fearful, disgusting, pleasant, and neutral stimuli in 12 pat...
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| Veröffentlicht in: | Behavioral neuroscience 2004-04, Vol.118 (2), p.429-437 |
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| creator | Buchanan, Tony W Tranel, Daniel Adolphs, Ralph |
| description | The acoustic startle reflex (ASR) is potentiated during negative emotion, but attenuated during positive emotional experience. The modulation of the ASR by fear depends critically on the amygdala. The authors investigated ASR modulation to fearful, disgusting, pleasant, and neutral stimuli in 12 patients with unilateral damage to the anteromedial temporal lobe including the amygdala (6 left, 6 right), 1 patient with bilateral temporal lobe damage including the amygdala, and 12 comparison participants. Both groups with unilateral damage, as well as the subject with bilateral damage, showed a complete lack of ASR potentiation to both fear and disgust stimuli. The findings suggest that potentiation of the ASR by disgust and fear depends on the integrity of the anteromedial temporal lobe. |
| doi_str_mv | 10.1037/0735-7044.118.2.429 |
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The modulation of the ASR by fear depends critically on the amygdala. The authors investigated ASR modulation to fearful, disgusting, pleasant, and neutral stimuli in 12 patients with unilateral damage to the anteromedial temporal lobe including the amygdala (6 left, 6 right), 1 patient with bilateral temporal lobe damage including the amygdala, and 12 comparison participants. Both groups with unilateral damage, as well as the subject with bilateral damage, showed a complete lack of ASR potentiation to both fear and disgust stimuli. 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The modulation of the ASR by fear depends critically on the amygdala. The authors investigated ASR modulation to fearful, disgusting, pleasant, and neutral stimuli in 12 patients with unilateral damage to the anteromedial temporal lobe including the amygdala (6 left, 6 right), 1 patient with bilateral temporal lobe damage including the amygdala, and 12 comparison participants. Both groups with unilateral damage, as well as the subject with bilateral damage, showed a complete lack of ASR potentiation to both fear and disgust stimuli. The findings suggest that potentiation of the ASR by disgust and fear depends on the integrity of the anteromedial temporal lobe.</description><subject>Acoustic Stimulation</subject><subject>Adult</subject><subject>Affect</subject><subject>Affectivity. Emotion</subject><subject>Amygdala - physiopathology</subject><subject>Auditory Stimulation</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Damage</subject><subject>Disgust</subject><subject>Electromyography</subject><subject>Emotional States</subject><subject>Emotions</subject><subject>Epilepsy - surgery</subject><subject>Fear</subject><subject>Fear & phobias</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - physiopathology</subject><subject>Human</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neurology</subject><subject>Neurosurgical Procedures</subject><subject>Personality. Affectivity</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Reflex, Startle - physiology</subject><subject>Reflexes</subject><subject>Startle Reflex</subject><subject>Temporal Lobe</subject><subject>Temporal Lobe - pathology</subject><subject>Temporal Lobe - surgery</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EotvCL0BCFhK9ZRl_JLaPpaWAtKgHytmynUmVksTBTg777_GqK1pxgMt4Ds_MO9ZDyBsGWwZCfQAl6kqBlFvG9JZvJTfPyIYZYSoALZ-TzR_ihJzmfA8AEmT9kpywmjHBFWzIzcW0YIojtr0b6C2Oc0yl2UWP9MqN7g7pxyGGn5l-X1xaBqTfYrsObunjRP2eXqNL1E0tverz3ZqXV-RF54aMr4_vGflx_en28ku1u_n89fJiV7ma8aUKIAXDtlNNaFsw0CgVvGGI5XLdeCVB6VrXThnpmmB8Bx1i51E1XphQyhk5f9g7p_hrxbzYsc8Bh8FNGNdsFdNaaGP-C3JQnBvNC_juL_A-rmkqn7ANk8IILdW_IA4lT9fqECkeoJBizgk7O6d-dGlvGdiDOnsQYw9ibFFnuS3qytTb4-rVFx2PM0dXBXh_BFwObuiSm0Kfn3BNLWopHjk3OzvnfSje-jBgtn7CJ4G_AY8lq3E</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Buchanan, Tony W</creator><creator>Tranel, Daniel</creator><creator>Adolphs, Ralph</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9166-8457</orcidid></search><sort><creationdate>20040401</creationdate><title>Anteromedial Temporal Lobe Damage Blocks Startle Modulation by Fear and Disgust</title><author>Buchanan, Tony W ; Tranel, Daniel ; Adolphs, Ralph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a512t-c0431edf76cdd090677cb91ee00886b74078585a794a6c9bf0feefbe76b39c6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acoustic Stimulation</topic><topic>Adult</topic><topic>Affect</topic><topic>Affectivity. Emotion</topic><topic>Amygdala - physiopathology</topic><topic>Auditory Stimulation</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain Damage</topic><topic>Disgust</topic><topic>Electromyography</topic><topic>Emotional States</topic><topic>Emotions</topic><topic>Epilepsy - surgery</topic><topic>Fear</topic><topic>Fear & phobias</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus - physiopathology</topic><topic>Human</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Neurology</topic><topic>Neurosurgical Procedures</topic><topic>Personality. Affectivity</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Reflex, Startle - physiology</topic><topic>Reflexes</topic><topic>Startle Reflex</topic><topic>Temporal Lobe</topic><topic>Temporal Lobe - pathology</topic><topic>Temporal Lobe - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buchanan, Tony W</creatorcontrib><creatorcontrib>Tranel, Daniel</creatorcontrib><creatorcontrib>Adolphs, Ralph</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via APA PsycArticles® (ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buchanan, Tony W</au><au>Tranel, Daniel</au><au>Adolphs, Ralph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anteromedial Temporal Lobe Damage Blocks Startle Modulation by Fear and Disgust</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>118</volume><issue>2</issue><spage>429</spage><epage>437</epage><pages>429-437</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>The acoustic startle reflex (ASR) is potentiated during negative emotion, but attenuated during positive emotional experience. The modulation of the ASR by fear depends critically on the amygdala. The authors investigated ASR modulation to fearful, disgusting, pleasant, and neutral stimuli in 12 patients with unilateral damage to the anteromedial temporal lobe including the amygdala (6 left, 6 right), 1 patient with bilateral temporal lobe damage including the amygdala, and 12 comparison participants. Both groups with unilateral damage, as well as the subject with bilateral damage, showed a complete lack of ASR potentiation to both fear and disgust stimuli. The findings suggest that potentiation of the ASR by disgust and fear depends on the integrity of the anteromedial temporal lobe.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>15113270</pmid><doi>10.1037/0735-7044.118.2.429</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9166-8457</orcidid></addata></record> |
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| subjects | Acoustic Stimulation Adult Affect Affectivity. Emotion Amygdala - physiopathology Auditory Stimulation Behavioral psychophysiology Biological and medical sciences Brain Brain Damage Disgust Electromyography Emotional States Emotions Epilepsy - surgery Fear Fear & phobias Female Fundamental and applied biological sciences. Psychology Hippocampus - physiopathology Human Humans Magnetic Resonance Imaging Male Neurology Neurosurgical Procedures Personality. Affectivity Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reflex, Startle - physiology Reflexes Startle Reflex Temporal Lobe Temporal Lobe - pathology Temporal Lobe - surgery |
| title | Anteromedial Temporal Lobe Damage Blocks Startle Modulation by Fear and Disgust |
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