Maldi-TOF analysis of portal sera of pancreatic cancer patients: identification of diabetogenic and antidiabetogenic peptides

Background: Pancreatic cancer (PC) associated diabetes mellitus (DM) might be consequent to the diabetogenic effects of tumour products, possibly acting via nitric oxide (NO). Our aims were: (1) to verify whether PC associated DM determines an increased hepatic NO and (2) using MALDI-TOF analysis, t...

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Veröffentlicht in:	Clinica chimica acta 2004-05, Vol.343 (1), p.119-127
Hauptverfasser:	Valerio, Anna, Basso, Daniela, Fogar, Paola, Falconi, Massimo, Greco, Eliana, Bassi, Claudio, Seraglia, Roberta, Abu-Hilal, Mohamed, Navaglia, Filippo, Zambon, Carlo-Federico, Gallo, Nicoletta, Falda, Alessandra, Pedrazzoli, Sergio, Plebani, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomarkers - analysis Cell Line, Tumor Cells, Cultured Diabetes Complications - blood Diabetes Complications - genetics Diabetes Complications - metabolism Diabetes mellitus Female Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Humans Liver - enzymology Liver - metabolism Maldi-TOF Male Middle Aged Nitric oxide Nitrites - analysis Pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - complications Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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