Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists
The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) α/γ agonist (S)-2-methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and associated dyslipidemia are described. 2 possesses a poten...
Gespeichert in:
| Veröffentlicht in: | Journal of medicinal chemistry 2004-05, Vol.47 (10), p.2422-2425 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2425 |
|---|---|
| container_issue | 10 |
| container_start_page | 2422 |
| container_title | Journal of medicinal chemistry |
| container_volume | 47 |
| creator | Xu, Yanping Rito, Christopher J Etgen, Garret J Ardecky, Robert J Bean, James S Bensch, William R Bosley, Jacob R Broderick, Carol L Brooks, Dawn A Dominianni, Samuel J Hahn, Patric J Liu, Sha Mais, Dale E Montrose-Rafizadeh, Chahrzad Ogilvie, Kathy M Oldham, Brian A Peters, Mary Rungta, Deepa K Shuker, Anthony J Stephenson, Gregory A Tripp, Allie E Wilson, Sarah B Winneroski, Leonard L Zink, Richard Kauffman, Raymond F McCarthy, James R |
| description | The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) α/γ agonist (S)-2-methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and associated dyslipidemia are described. 2 possesses a potent dual hPPAR α/γ agonist profile (IC50 = 28 and 10 nM; EC50 = 9 and 4 nM, respectively, for hPPARα and hPPARγ). In preclinical models, 2 substantially improves insulin sensitivity and potently reverses diabetic hyperglycemia while significantly improving overall lipid homeostasis. |
| doi_str_mv | 10.1021/jm0342616 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71882928</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71882928</sourcerecordid><originalsourceid>FETCH-LOGICAL-a379t-e8545d3cc03fa347ae836447b5f8cb51e5983626a02733737f6ab45077cb614b3</originalsourceid><addsrcrecordid>eNptkc1u1DAQxy0EokvhwAsgX0DiEOqPOM5yi7ZAEStYseVDXCzHcbreOvZiJ9XmxpUzT4J4jz4ET4LprloOnMYz_vk_4_8A8BCjZxgRfLTuEM1JgYtbYIIZQVleovw2mCBESEYKQg_AvRjXCCGKCb0LDjDDmNGSTcCPYx3NmYPSNXA5un6V0gh9Cy9_ZlUYrd-OWTp2ul-NdjU2wSvjnOyMgpUyTXz--9t3WMG3_kJbOLMyXj0-HqSFCx381kTfabgI3ppWB9n7kFWqNxey1w18r5XepFJqdnT5C1Zn3pnYx_vgTitt1A_28RB8ePnidHaSzd-9ej2r5pmkfNpnumQ5a6hSiLaS5lzqkhZ5zmvWlqpmWLNpKpBCIsIp5ZS3haxzhjhXdYHzmh6CJzvdTfBfBx170ZmotLXSaT9EwXFZkikpE_h0B6rgYwy6FZtgOhlGgZH4uwFxvYHEPtqLDnWnmxtyb3kCHu8BGZW0bZBOmfgPxzFBV1y245Ilent9L8O5KNJnmDhdLAX7_ObLp-XHEzG_0ZUqirUfgkve_WfAP_FArUU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71882928</pqid></control><display><type>article</type><title>Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists</title><source>ACS Publications</source><source>MEDLINE</source><creator>Xu, Yanping ; Rito, Christopher J ; Etgen, Garret J ; Ardecky, Robert J ; Bean, James S ; Bensch, William R ; Bosley, Jacob R ; Broderick, Carol L ; Brooks, Dawn A ; Dominianni, Samuel J ; Hahn, Patric J ; Liu, Sha ; Mais, Dale E ; Montrose-Rafizadeh, Chahrzad ; Ogilvie, Kathy M ; Oldham, Brian A ; Peters, Mary ; Rungta, Deepa K ; Shuker, Anthony J ; Stephenson, Gregory A ; Tripp, Allie E ; Wilson, Sarah B ; Winneroski, Leonard L ; Zink, Richard ; Kauffman, Raymond F ; McCarthy, James R</creator><creatorcontrib>Xu, Yanping ; Rito, Christopher J ; Etgen, Garret J ; Ardecky, Robert J ; Bean, James S ; Bensch, William R ; Bosley, Jacob R ; Broderick, Carol L ; Brooks, Dawn A ; Dominianni, Samuel J ; Hahn, Patric J ; Liu, Sha ; Mais, Dale E ; Montrose-Rafizadeh, Chahrzad ; Ogilvie, Kathy M ; Oldham, Brian A ; Peters, Mary ; Rungta, Deepa K ; Shuker, Anthony J ; Stephenson, Gregory A ; Tripp, Allie E ; Wilson, Sarah B ; Winneroski, Leonard L ; Zink, Richard ; Kauffman, Raymond F ; McCarthy, James R</creatorcontrib><description>The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) α/γ agonist (S)-2-methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and associated dyslipidemia are described. 2 possesses a potent dual hPPAR α/γ agonist profile (IC50 = 28 and 10 nM; EC50 = 9 and 4 nM, respectively, for hPPARα and hPPARγ). In preclinical models, 2 substantially improves insulin sensitivity and potently reverses diabetic hyperglycemia while significantly improving overall lipid homeostasis.</description><identifier>ISSN: 0022-2623</identifier><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm0342616</identifier><identifier>PMID: 15115385</identifier><identifier>CODEN: JMCMAR</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Binding, Competitive ; Biological and medical sciences ; Cell Line ; Diabetes Mellitus, Type 2 - drug therapy ; Female ; General and cellular metabolism. Vitamins ; Humans ; Hyperlipidemias - drug therapy ; Hypoglycemic Agents - chemical synthesis ; Hypoglycemic Agents - chemistry ; Hypoglycemic Agents - pharmacology ; Hypolipidemic Agents - chemical synthesis ; Hypolipidemic Agents - chemistry ; Hypolipidemic Agents - pharmacology ; Medical sciences ; Pharmacology. Drug treatments ; Phenylpropionates - chemical synthesis ; Phenylpropionates - chemistry ; Phenylpropionates - pharmacology ; Radioligand Assay ; Rats ; Rats, Zucker ; Receptors, Cytoplasmic and Nuclear - agonists ; Stereoisomerism ; Structure-Activity Relationship ; Thiophenes - chemical synthesis ; Thiophenes - chemistry ; Thiophenes - pharmacology ; Transcription Factors - agonists</subject><ispartof>Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2422-2425</ispartof><rights>Copyright © 2004 American Chemical Society</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a379t-e8545d3cc03fa347ae836447b5f8cb51e5983626a02733737f6ab45077cb614b3</citedby><cites>FETCH-LOGICAL-a379t-e8545d3cc03fa347ae836447b5f8cb51e5983626a02733737f6ab45077cb614b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm0342616$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm0342616$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15712085$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15115385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Yanping</creatorcontrib><creatorcontrib>Rito, Christopher J</creatorcontrib><creatorcontrib>Etgen, Garret J</creatorcontrib><creatorcontrib>Ardecky, Robert J</creatorcontrib><creatorcontrib>Bean, James S</creatorcontrib><creatorcontrib>Bensch, William R</creatorcontrib><creatorcontrib>Bosley, Jacob R</creatorcontrib><creatorcontrib>Broderick, Carol L</creatorcontrib><creatorcontrib>Brooks, Dawn A</creatorcontrib><creatorcontrib>Dominianni, Samuel J</creatorcontrib><creatorcontrib>Hahn, Patric J</creatorcontrib><creatorcontrib>Liu, Sha</creatorcontrib><creatorcontrib>Mais, Dale E</creatorcontrib><creatorcontrib>Montrose-Rafizadeh, Chahrzad</creatorcontrib><creatorcontrib>Ogilvie, Kathy M</creatorcontrib><creatorcontrib>Oldham, Brian A</creatorcontrib><creatorcontrib>Peters, Mary</creatorcontrib><creatorcontrib>Rungta, Deepa K</creatorcontrib><creatorcontrib>Shuker, Anthony J</creatorcontrib><creatorcontrib>Stephenson, Gregory A</creatorcontrib><creatorcontrib>Tripp, Allie E</creatorcontrib><creatorcontrib>Wilson, Sarah B</creatorcontrib><creatorcontrib>Winneroski, Leonard L</creatorcontrib><creatorcontrib>Zink, Richard</creatorcontrib><creatorcontrib>Kauffman, Raymond F</creatorcontrib><creatorcontrib>McCarthy, James R</creatorcontrib><title>Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><description>The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) α/γ agonist (S)-2-methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and associated dyslipidemia are described. 2 possesses a potent dual hPPAR α/γ agonist profile (IC50 = 28 and 10 nM; EC50 = 9 and 4 nM, respectively, for hPPARα and hPPARγ). In preclinical models, 2 substantially improves insulin sensitivity and potently reverses diabetic hyperglycemia while significantly improving overall lipid homeostasis.</description><subject>Animals</subject><subject>Binding, Competitive</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Humans</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Hypoglycemic Agents - chemical synthesis</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypolipidemic Agents - chemical synthesis</subject><subject>Hypolipidemic Agents - chemistry</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylpropionates - chemical synthesis</subject><subject>Phenylpropionates - chemistry</subject><subject>Phenylpropionates - pharmacology</subject><subject>Radioligand Assay</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Receptors, Cytoplasmic and Nuclear - agonists</subject><subject>Stereoisomerism</subject><subject>Structure-Activity Relationship</subject><subject>Thiophenes - chemical synthesis</subject><subject>Thiophenes - chemistry</subject><subject>Thiophenes - pharmacology</subject><subject>Transcription Factors - agonists</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1u1DAQxy0EokvhwAsgX0DiEOqPOM5yi7ZAEStYseVDXCzHcbreOvZiJ9XmxpUzT4J4jz4ET4LprloOnMYz_vk_4_8A8BCjZxgRfLTuEM1JgYtbYIIZQVleovw2mCBESEYKQg_AvRjXCCGKCb0LDjDDmNGSTcCPYx3NmYPSNXA5un6V0gh9Cy9_ZlUYrd-OWTp2ul-NdjU2wSvjnOyMgpUyTXz--9t3WMG3_kJbOLMyXj0-HqSFCx381kTfabgI3ppWB9n7kFWqNxey1w18r5XepFJqdnT5C1Zn3pnYx_vgTitt1A_28RB8ePnidHaSzd-9ej2r5pmkfNpnumQ5a6hSiLaS5lzqkhZ5zmvWlqpmWLNpKpBCIsIp5ZS3haxzhjhXdYHzmh6CJzvdTfBfBx170ZmotLXSaT9EwXFZkikpE_h0B6rgYwy6FZtgOhlGgZH4uwFxvYHEPtqLDnWnmxtyb3kCHu8BGZW0bZBOmfgPxzFBV1y245Ilent9L8O5KNJnmDhdLAX7_ObLp-XHEzG_0ZUqirUfgkve_WfAP_FArUU</recordid><startdate>20040506</startdate><enddate>20040506</enddate><creator>Xu, Yanping</creator><creator>Rito, Christopher J</creator><creator>Etgen, Garret J</creator><creator>Ardecky, Robert J</creator><creator>Bean, James S</creator><creator>Bensch, William R</creator><creator>Bosley, Jacob R</creator><creator>Broderick, Carol L</creator><creator>Brooks, Dawn A</creator><creator>Dominianni, Samuel J</creator><creator>Hahn, Patric J</creator><creator>Liu, Sha</creator><creator>Mais, Dale E</creator><creator>Montrose-Rafizadeh, Chahrzad</creator><creator>Ogilvie, Kathy M</creator><creator>Oldham, Brian A</creator><creator>Peters, Mary</creator><creator>Rungta, Deepa K</creator><creator>Shuker, Anthony J</creator><creator>Stephenson, Gregory A</creator><creator>Tripp, Allie E</creator><creator>Wilson, Sarah B</creator><creator>Winneroski, Leonard L</creator><creator>Zink, Richard</creator><creator>Kauffman, Raymond F</creator><creator>McCarthy, James R</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040506</creationdate><title>Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists</title><author>Xu, Yanping ; Rito, Christopher J ; Etgen, Garret J ; Ardecky, Robert J ; Bean, James S ; Bensch, William R ; Bosley, Jacob R ; Broderick, Carol L ; Brooks, Dawn A ; Dominianni, Samuel J ; Hahn, Patric J ; Liu, Sha ; Mais, Dale E ; Montrose-Rafizadeh, Chahrzad ; Ogilvie, Kathy M ; Oldham, Brian A ; Peters, Mary ; Rungta, Deepa K ; Shuker, Anthony J ; Stephenson, Gregory A ; Tripp, Allie E ; Wilson, Sarah B ; Winneroski, Leonard L ; Zink, Richard ; Kauffman, Raymond F ; McCarthy, James R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a379t-e8545d3cc03fa347ae836447b5f8cb51e5983626a02733737f6ab45077cb614b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Binding, Competitive</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Female</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Humans</topic><topic>Hyperlipidemias - drug therapy</topic><topic>Hypoglycemic Agents - chemical synthesis</topic><topic>Hypoglycemic Agents - chemistry</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypolipidemic Agents - chemical synthesis</topic><topic>Hypolipidemic Agents - chemistry</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylpropionates - chemical synthesis</topic><topic>Phenylpropionates - chemistry</topic><topic>Phenylpropionates - pharmacology</topic><topic>Radioligand Assay</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>Receptors, Cytoplasmic and Nuclear - agonists</topic><topic>Stereoisomerism</topic><topic>Structure-Activity Relationship</topic><topic>Thiophenes - chemical synthesis</topic><topic>Thiophenes - chemistry</topic><topic>Thiophenes - pharmacology</topic><topic>Transcription Factors - agonists</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Yanping</creatorcontrib><creatorcontrib>Rito, Christopher J</creatorcontrib><creatorcontrib>Etgen, Garret J</creatorcontrib><creatorcontrib>Ardecky, Robert J</creatorcontrib><creatorcontrib>Bean, James S</creatorcontrib><creatorcontrib>Bensch, William R</creatorcontrib><creatorcontrib>Bosley, Jacob R</creatorcontrib><creatorcontrib>Broderick, Carol L</creatorcontrib><creatorcontrib>Brooks, Dawn A</creatorcontrib><creatorcontrib>Dominianni, Samuel J</creatorcontrib><creatorcontrib>Hahn, Patric J</creatorcontrib><creatorcontrib>Liu, Sha</creatorcontrib><creatorcontrib>Mais, Dale E</creatorcontrib><creatorcontrib>Montrose-Rafizadeh, Chahrzad</creatorcontrib><creatorcontrib>Ogilvie, Kathy M</creatorcontrib><creatorcontrib>Oldham, Brian A</creatorcontrib><creatorcontrib>Peters, Mary</creatorcontrib><creatorcontrib>Rungta, Deepa K</creatorcontrib><creatorcontrib>Shuker, Anthony J</creatorcontrib><creatorcontrib>Stephenson, Gregory A</creatorcontrib><creatorcontrib>Tripp, Allie E</creatorcontrib><creatorcontrib>Wilson, Sarah B</creatorcontrib><creatorcontrib>Winneroski, Leonard L</creatorcontrib><creatorcontrib>Zink, Richard</creatorcontrib><creatorcontrib>Kauffman, Raymond F</creatorcontrib><creatorcontrib>McCarthy, James R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Yanping</au><au>Rito, Christopher J</au><au>Etgen, Garret J</au><au>Ardecky, Robert J</au><au>Bean, James S</au><au>Bensch, William R</au><au>Bosley, Jacob R</au><au>Broderick, Carol L</au><au>Brooks, Dawn A</au><au>Dominianni, Samuel J</au><au>Hahn, Patric J</au><au>Liu, Sha</au><au>Mais, Dale E</au><au>Montrose-Rafizadeh, Chahrzad</au><au>Ogilvie, Kathy M</au><au>Oldham, Brian A</au><au>Peters, Mary</au><au>Rungta, Deepa K</au><au>Shuker, Anthony J</au><au>Stephenson, Gregory A</au><au>Tripp, Allie E</au><au>Wilson, Sarah B</au><au>Winneroski, Leonard L</au><au>Zink, Richard</au><au>Kauffman, Raymond F</au><au>McCarthy, James R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J. Med. Chem</addtitle><date>2004-05-06</date><risdate>2004</risdate><volume>47</volume><issue>10</issue><spage>2422</spage><epage>2425</epage><pages>2422-2425</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><coden>JMCMAR</coden><abstract>The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) α/γ agonist (S)-2-methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and associated dyslipidemia are described. 2 possesses a potent dual hPPAR α/γ agonist profile (IC50 = 28 and 10 nM; EC50 = 9 and 4 nM, respectively, for hPPARα and hPPARγ). In preclinical models, 2 substantially improves insulin sensitivity and potently reverses diabetic hyperglycemia while significantly improving overall lipid homeostasis.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>15115385</pmid><doi>10.1021/jm0342616</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2422-2425 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71882928 |
| source | ACS Publications; MEDLINE |
| subjects | Animals Binding, Competitive Biological and medical sciences Cell Line Diabetes Mellitus, Type 2 - drug therapy Female General and cellular metabolism. Vitamins Humans Hyperlipidemias - drug therapy Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Hypolipidemic Agents - chemical synthesis Hypolipidemic Agents - chemistry Hypolipidemic Agents - pharmacology Medical sciences Pharmacology. Drug treatments Phenylpropionates - chemical synthesis Phenylpropionates - chemistry Phenylpropionates - pharmacology Radioligand Assay Rats Rats, Zucker Receptors, Cytoplasmic and Nuclear - agonists Stereoisomerism Structure-Activity Relationship Thiophenes - chemical synthesis Thiophenes - chemistry Thiophenes - pharmacology Transcription Factors - agonists |
| title | Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T12%3A14%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Design%20and%20Synthesis%20of%20%CE%B1-Aryloxy-%CE%B1-methylhydrocinnamic%20Acids:%E2%80%89%20A%20Novel%20Class%20of%20Dual%20Peroxisome%20Proliferator-Activated%20Receptor%20%CE%B1/%CE%B3%20Agonists&rft.jtitle=Journal%20of%20medicinal%20chemistry&rft.au=Xu,%20Yanping&rft.date=2004-05-06&rft.volume=47&rft.issue=10&rft.spage=2422&rft.epage=2425&rft.pages=2422-2425&rft.issn=0022-2623&rft.eissn=1520-4804&rft.coden=JMCMAR&rft_id=info:doi/10.1021/jm0342616&rft_dat=%3Cproquest_cross%3E71882928%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71882928&rft_id=info:pmid/15115385&rfr_iscdi=true |