Randomised controlled trial of graded exercise in chronic fatigue syndrome
Objective: To investigate whether 12 weeks of graded exercise with pacing would improve specific physiological, psychological and cognitive functions in people with chronic fatigue syndrome (CFS). Design: Randomised controlled trial. Setting: Human performance laboratory at the University of Western...
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| Veröffentlicht in: | Medical journal of Australia 2004-05, Vol.180 (9), p.444-448 |
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| creator | Wallman, Karen E Morton, Alan R Goodman, Carmel Grove, Robert Guilfoyle, Andrew M |
| description | Objective: To investigate whether 12 weeks of graded exercise with pacing would improve specific physiological, psychological and cognitive functions in people with chronic fatigue syndrome (CFS).
Design: Randomised controlled trial.
Setting: Human performance laboratory at the University of Western Australia.
Participants: 61 patients aged between 16 and 74 years diagnosed with CFS.
Interventions: Either graded exercise with pacing (32 patients) or relaxation/flexibility therapy (29 patients) performed twice a day over 12 weeks.
Main outcome measures: Changes in any of the physiological, psychological or cognitive variables assessed.
Results: Following the graded exercise intervention, scores were improved for resting systolic blood pressure (P = 0.018), work capacity (W·kg‐1) (P = 0.019), net blood lactate production (P = 0.036), depression (P = 0.027) and performance on a modified Stroop Colour Word test (P = 0.029). Rating of perceived exertion scores, associated with an exercise test, was lower after graded exercise (P = 0.013). No such changes were observed in the relaxation/flexibility condition, which served as an attention‐placebo control.
Conclusions: Graded exercise was associated with improvements in physical work capacity, as well as in specific psychological and cognitive variables. Improvements may be associated with the abandonment of avoidance behaviours. |
| doi_str_mv | 10.5694/j.1326-5377.2004.tb06019.x |
| format | Article |
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Design: Randomised controlled trial.
Setting: Human performance laboratory at the University of Western Australia.
Participants: 61 patients aged between 16 and 74 years diagnosed with CFS.
Interventions: Either graded exercise with pacing (32 patients) or relaxation/flexibility therapy (29 patients) performed twice a day over 12 weeks.
Main outcome measures: Changes in any of the physiological, psychological or cognitive variables assessed.
Results: Following the graded exercise intervention, scores were improved for resting systolic blood pressure (P = 0.018), work capacity (W·kg‐1) (P = 0.019), net blood lactate production (P = 0.036), depression (P = 0.027) and performance on a modified Stroop Colour Word test (P = 0.029). Rating of perceived exertion scores, associated with an exercise test, was lower after graded exercise (P = 0.013). No such changes were observed in the relaxation/flexibility condition, which served as an attention‐placebo control.
Conclusions: Graded exercise was associated with improvements in physical work capacity, as well as in specific psychological and cognitive variables. Improvements may be associated with the abandonment of avoidance behaviours.</description><identifier>ISSN: 0025-729X</identifier><identifier>EISSN: 1326-5377</identifier><identifier>DOI: 10.5694/j.1326-5377.2004.tb06019.x</identifier><identifier>PMID: 15115421</identifier><identifier>CODEN: MJAUAJ</identifier><language>eng</language><publisher>Sydney: Australasian Medical Publishing Company</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Chronic fatigue syndrome ; Cognition ; Cognitive ability ; Depressive Disorder - complications ; Depressive Disorder - diagnosis ; Exercise ; Fatigue Syndrome, Chronic - physiopathology ; Fatigue Syndrome, Chronic - psychology ; Fatigue Syndrome, Chronic - therapy ; Female ; General aspects ; Heart rate ; Hemodynamics ; Humans ; Immune system diseases ; Laboratories ; Male ; Medical sciences ; Mental depression ; Middle Aged ; Physical fitness ; Physiology ; Psychometrics ; Relaxation Therapy</subject><ispartof>Medical journal of Australia, 2004-05, Vol.180 (9), p.444-448</ispartof><rights>2004 AMPCo Pty Ltd. All rights reserved</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 The Medical Journal of Australia</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4309-b6c2533f98d121fb7dcd3f4cb8080d71bf989d19f10ed880a83ec0da053042a93</citedby><cites>FETCH-LOGICAL-c4309-b6c2533f98d121fb7dcd3f4cb8080d71bf989d19f10ed880a83ec0da053042a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.5694%2Fj.1326-5377.2004.tb06019.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.5694%2Fj.1326-5377.2004.tb06019.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15725911$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15115421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wallman, Karen E</creatorcontrib><creatorcontrib>Morton, Alan R</creatorcontrib><creatorcontrib>Goodman, Carmel</creatorcontrib><creatorcontrib>Grove, Robert</creatorcontrib><creatorcontrib>Guilfoyle, Andrew M</creatorcontrib><title>Randomised controlled trial of graded exercise in chronic fatigue syndrome</title><title>Medical journal of Australia</title><addtitle>Med J Aust</addtitle><description>Objective: To investigate whether 12 weeks of graded exercise with pacing would improve specific physiological, psychological and cognitive functions in people with chronic fatigue syndrome (CFS).
Design: Randomised controlled trial.
Setting: Human performance laboratory at the University of Western Australia.
Participants: 61 patients aged between 16 and 74 years diagnosed with CFS.
Interventions: Either graded exercise with pacing (32 patients) or relaxation/flexibility therapy (29 patients) performed twice a day over 12 weeks.
Main outcome measures: Changes in any of the physiological, psychological or cognitive variables assessed.
Results: Following the graded exercise intervention, scores were improved for resting systolic blood pressure (P = 0.018), work capacity (W·kg‐1) (P = 0.019), net blood lactate production (P = 0.036), depression (P = 0.027) and performance on a modified Stroop Colour Word test (P = 0.029). Rating of perceived exertion scores, associated with an exercise test, was lower after graded exercise (P = 0.013). No such changes were observed in the relaxation/flexibility condition, which served as an attention‐placebo control.
Conclusions: Graded exercise was associated with improvements in physical work capacity, as well as in specific psychological and cognitive variables. Improvements may be associated with the abandonment of avoidance behaviours.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chronic fatigue syndrome</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Depressive Disorder - complications</subject><subject>Depressive Disorder - diagnosis</subject><subject>Exercise</subject><subject>Fatigue Syndrome, Chronic - physiopathology</subject><subject>Fatigue Syndrome, Chronic - psychology</subject><subject>Fatigue Syndrome, Chronic - therapy</subject><subject>Female</subject><subject>General aspects</subject><subject>Heart rate</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Immune system diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Physical fitness</subject><subject>Physiology</subject><subject>Psychometrics</subject><subject>Relaxation Therapy</subject><issn>0025-729X</issn><issn>1326-5377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1P3DAQhq2qCBbav1BFSOWWdMaON3FvKwS0CISEWqk3y_EHzSobUzsRu_8epxsB6q0nz2ie8bx6CDlFKPhSlF_WBTK6zDmrqoIClMXQwBJQFNt3ZPEyek8WAJTnFRW_jshxjOvUIqfVITlCjshLigtyfa964zdttCbTvh-C77pUDqFVXeZd9hCUSb3d2qATlLV9pn8H37c6c2poH0abxV1vgt_YD-TAqS7aj_N7Qn5eXvw4_5bf3F19P1_d5LpkIPJmqSlnzInaIEXXVEYb5krd1FCDqbBJE2FQOARr6hpUzawGo4AzKKkS7ISc7f99DP7PaOMgU3xtu0711o9RVljXVMAEnv4Drv0Y-pRNUpZMYskm6Ose0sHHGKyTj6HdqLCTCHLSLddycionp3LSLWfdcpuWP80XxmZjzevq7DcBn2dARa06F1SfNL7hKsoFTtxqzz21nd39RwR5e72if2v2DMSEnOQ</recordid><startdate>20040503</startdate><enddate>20040503</enddate><creator>Wallman, Karen E</creator><creator>Morton, Alan R</creator><creator>Goodman, Carmel</creator><creator>Grove, Robert</creator><creator>Guilfoyle, Andrew M</creator><general>Australasian Medical Publishing Company</general><general>Australasian Medical Publishing Company Proprietary, Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040503</creationdate><title>Randomised controlled trial of graded exercise in chronic fatigue syndrome</title><author>Wallman, Karen E ; Morton, Alan R ; Goodman, Carmel ; Grove, Robert ; Guilfoyle, Andrew M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4309-b6c2533f98d121fb7dcd3f4cb8080d71bf989d19f10ed880a83ec0da053042a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chronic fatigue syndrome</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Depressive Disorder - complications</topic><topic>Depressive Disorder - diagnosis</topic><topic>Exercise</topic><topic>Fatigue Syndrome, Chronic - physiopathology</topic><topic>Fatigue Syndrome, Chronic - psychology</topic><topic>Fatigue Syndrome, Chronic - therapy</topic><topic>Female</topic><topic>General aspects</topic><topic>Heart rate</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Immune system diseases</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Physical fitness</topic><topic>Physiology</topic><topic>Psychometrics</topic><topic>Relaxation Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallman, Karen E</creatorcontrib><creatorcontrib>Morton, Alan R</creatorcontrib><creatorcontrib>Goodman, Carmel</creatorcontrib><creatorcontrib>Grove, Robert</creatorcontrib><creatorcontrib>Guilfoyle, Andrew M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Medical journal of Australia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallman, Karen E</au><au>Morton, Alan R</au><au>Goodman, Carmel</au><au>Grove, Robert</au><au>Guilfoyle, Andrew M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomised controlled trial of graded exercise in chronic fatigue syndrome</atitle><jtitle>Medical journal of Australia</jtitle><addtitle>Med J Aust</addtitle><date>2004-05-03</date><risdate>2004</risdate><volume>180</volume><issue>9</issue><spage>444</spage><epage>448</epage><pages>444-448</pages><issn>0025-729X</issn><eissn>1326-5377</eissn><coden>MJAUAJ</coden><abstract>Objective: To investigate whether 12 weeks of graded exercise with pacing would improve specific physiological, psychological and cognitive functions in people with chronic fatigue syndrome (CFS).
Design: Randomised controlled trial.
Setting: Human performance laboratory at the University of Western Australia.
Participants: 61 patients aged between 16 and 74 years diagnosed with CFS.
Interventions: Either graded exercise with pacing (32 patients) or relaxation/flexibility therapy (29 patients) performed twice a day over 12 weeks.
Main outcome measures: Changes in any of the physiological, psychological or cognitive variables assessed.
Results: Following the graded exercise intervention, scores were improved for resting systolic blood pressure (P = 0.018), work capacity (W·kg‐1) (P = 0.019), net blood lactate production (P = 0.036), depression (P = 0.027) and performance on a modified Stroop Colour Word test (P = 0.029). Rating of perceived exertion scores, associated with an exercise test, was lower after graded exercise (P = 0.013). No such changes were observed in the relaxation/flexibility condition, which served as an attention‐placebo control.
Conclusions: Graded exercise was associated with improvements in physical work capacity, as well as in specific psychological and cognitive variables. Improvements may be associated with the abandonment of avoidance behaviours.</abstract><cop>Sydney</cop><pub>Australasian Medical Publishing Company</pub><pmid>15115421</pmid><doi>10.5694/j.1326-5377.2004.tb06019.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Medical journal of Australia, 2004-05, Vol.180 (9), p.444-448 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adolescent Adult Aged Biological and medical sciences Chronic fatigue syndrome Cognition Cognitive ability Depressive Disorder - complications Depressive Disorder - diagnosis Exercise Fatigue Syndrome, Chronic - physiopathology Fatigue Syndrome, Chronic - psychology Fatigue Syndrome, Chronic - therapy Female General aspects Heart rate Hemodynamics Humans Immune system diseases Laboratories Male Medical sciences Mental depression Middle Aged Physical fitness Physiology Psychometrics Relaxation Therapy |
| title | Randomised controlled trial of graded exercise in chronic fatigue syndrome |
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